Senescence-associated alterations in the extracellular matrix: deciphering their role in the regulation of cellular function

The extracellular matrix (ECM) is a dynamic structural network that provides a physical scaffolding, as well as biochemical factors that maintain normal tissue homeostasis and thus its disruption is implicated in many pathological conditions. On the other hand, senescent cells express a particular secretory phenotype, affecting the composition and organization of the surrounding ECM and modulating their microenvironment. As accumulation of senescent cells may be linked to the manifestation of several age-related conditions, senescence-associated ECM alterations may serve as targets for novel anti-aging treatment modalities. Here, we will review characteristic changes in the ECM elicited by cellular senescence and we will discuss the complex interplay between ECM and senescent cells, in relation to normal aging and selected age-associated pathologies.

Automated summary

The extracellular matrix (ECM) plays a crucial role in maintaining tissue homeostasis and fighting against aging. Cellular senescence can alter the composition of ECM, and the interaction between accumulated senescent cells and ECM may contribute to age-related pathologies.