期刊
MECHANISMS OF DEVELOPMENT
卷 141, 期 -, 页码 70-77出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2016.05.003
关键词
Angiogenesis; Anti-angiogenesis; Tissue grafts; Tumor growth; Wound healing
资金
- European Union Seventh Framework Programme [278570]
During avian development the mesodermal layers of the allantois and chorion fuse to form the chorioallantoic membrane (CAM). This structure rapidly expands generating a rich vascular network that provides an interface for gas and waste exchange. The CAM allows to study tissue grafts, tumor growth and metastasis, wound healing, drugs delivery and toxicologic analysis, and angiogenic and anti-angiogenic molecules. The CAM is relatively simple, quick, and low-cost model that allows screening of a large number of pharmacological samples in a short time; does not require administrative procedures for obtaining ethics committee approval for animal experimentation. Moreover, being naturally immunodeficient, the chick embryo may receive transplantations from different tissues and species, without immune responses. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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