4.6 Letter

Adverse effects of delta-9-tetrahydrocannabinol on sickle red blood cells

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Summary: Haemoglobin S polymerization in the red blood cells of individuals with sickle cell anaemia can cause cellular alterations. Piezo1 protein activation and Gardos channel activity decrease sickle red blood cell deformability and increase their propensity to sickle and adhere to laminin. These results suggest that Piezo1 may represent a potential therapeutic target for sickle cell anaemia.

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