Adverse effects of delta-9-tetrahydrocannabinol on sickle red blood cells

THC triggers a pronounced entry of Ca2+, which may be deleterious, into sickle cell red blood cells via activation of the TRPV2 channel. image

Automated summary

THC activates the TRPV2 channel, resulting in a significant influx of calcium ions into sickle cell red blood cells, which may have harmful effects.