The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL

In this retrospective international multicenter study, we describe the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders (small lymphocytic lymphoma and high-count monoclonal B lymphocytosis) infected by SARS-CoV-2, including the development of post-COVID condition. Data from 1540 patients with CLL infected by SARS-CoV-2 from January 2020 to May 2022 were included in the analysis and assigned to four phases based on cases disposition and SARS-CoV-2 variants emergence. Post-COVID condition was defined according to the WHO criteria. Patients infected during the most recent phases of the pandemic, though carrying a higher comorbidity burden, were less often hospitalized, rarely needed intensive care unit admission, or died compared to patients infected during the initial phases. The 4-month overall survival (OS) improved through the phases, from 68% to 83%, p = .0015. Age, comorbidity, CLL-directed treatment, but not vaccination status, emerged as risk factors for mortality. Among survivors, 6.65% patients had a reinfection, usually milder than the initial one, and 16.5% developed post-COVID condition. The latter was characterized by fatigue, dyspnea, lasting cough, and impaired concentration. Infection severity was the only risk factor for developing post-COVID. The median time to resolution of the post-COVID condition was 4.7 months. OS in patients with CLL improved during the different phases of the pandemic, likely due to the improvement of prophylactic and therapeutic measures against SARS-CoV-2 as well as the emergence of milder variants. However, mortality remained relevant and a significant number of patients developed post-COVID conditions, warranting further investigations.

Automated summary

In this retrospective international multicenter study, the clinical characteristics and outcomes of patients with chronic lymphocytic leukemia (CLL) and related disorders infected by SARS-CoV-2 were described. The study also investigated the development of post-COVID condition. The data showed that patients infected in the most recent phases of the pandemic had lower hospitalization rates, ICU admission rates, and mortality compared to those infected in the initial phases. Overall survival improved throughout the phases. Age, comorbidity, and CLL-directed treatment were identified as risk factors for mortality. A significant number of patients developed post-COVID condition, characterized by fatigue, dyspnea, lasting cough, and impaired concentration. The severity of infection was the only risk factor for developing post-COVID. Further investigations are warranted to understand the impact of COVID-19 on CLL patients.