期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 157, 期 -, 页码 17-29出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2016.07.001
关键词
Nonalcoholic steatohepatitis; Hypercholesterolemia; Endoplasmic reticulum stress; Unfolded protein response; MicroRNAs
资金
- Scientific and Technological Research Council of Turkey (TUBITAK) [115S464]
- Marmara University Research Fund, Turkey [SAG-C-DRP-110915-0419]
Nonalcoholic steatohepatitis (NASH) is considered to be a common health problem since the incidence of nonalcoholic fatty liver disease (NAFLD) has increased in recent years. Disturbed hepatic cholesterol homeostasis and free cholesterol accumulation in liver results in increased oxidative stress leading to the endoplasmic reticulum (ER) stress. Activated ER stress maintains protein homeostasis however, delayed or inadequate ER stress responses may induce fat accumulation, insulin resistance, inflammation, apoptosis, and autophagy, all of which increase with age and play crucial roles in the pathogenesis of NASH. In aging research, there is a growing interest for the role of ER stress in the progression of NASH since aging seems to favor NAFLD according to its pathogenesis. On the other hand, specific microRNAs (miRNAs) expression profiles are strongly related with ER stress as well as NASH progresses. This review highlights molecular mechanisms related to ER stress in the pathogenesis of NASH and miRNAs for the progression and treatment of the disease. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据