期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 154, 期 -, 页码 43-48出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2016.02.004
关键词
Telomeres; Cognition; Cognitive ageing; Physical ageing
资金
- Age UK (The Disconnected Mind project)
- UK's Biotechnology and Biological Sciences Research Council (BBSRC)
- Royal Society
- Chief Scientist Office of the Scottish Government
- BBSRC
- Medical Research Council (MRC)
- NIHR Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust
- Newcastle University
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [G0500997, G0601333] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- Medical Research Council [G0500997, G0601333, MR/K026992/1, MR/M013111/1] Funding Source: researchfish
Telomere length is hypothesised to be a biological marker of both cognitive and physical ageing. Here we measure telomere length, and cognitive and physical abilities at mean ages 70, 73 and 76 years in the Lothian Birth Cohort 1936 (LBC1936), and at mean ages 79, 87, 90 and 92 years in the Lothian Birth Cohort 1921 (LBC1921). We investigate whether telomere length change predicts change in cognitive and physical abilities. In LBC1936 telomere length decreased by an average of 65 base pairs per year and in LBC1921 by 69 base pairs per year. However, change in telomere length did not predict change in cognitive or physical abilities. This study shows that, although cognitive ability, walking speed, lung function and grip strength all decline with age, they do so independently of telomere length shortening. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据