4.5 Article

Association between positive blood culture and clinical outcomes among children treated for sepsis in the emergency department

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Critical Care Medicine

Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce*

Kusum Menon et al.

Summary: The study aimed to determine the associations of demographic, clinical, laboratory, organ dysfunction, and illness severity variable values with sepsis, severe sepsis, or septic shock in children with infection, as well as multiple organ dysfunction or death in children with sepsis, severe sepsis, or septic shock. The findings revealed significant associations between multiple markers of organ dysfunction and the outcomes of interest.

CRITICAL CARE MEDICINE (2022)

Article Pediatrics

Refining the Pediatric Multiple Organ Dysfunction Syndrome

Scott L. Weiss et al.

Summary: Pediatric multiple organ dysfunction syndrome (MODS) should be reserved for patients with a systemic pathologic state resulting from a common mechanism that affects numerous organ systems simultaneously, while organ injuries attributable to distinct mechanisms should be considered as additive organ system dysfunctions but not MODS syndrome. Differentiating these states can help shift clinical and research priorities towards more holistic strategies.

PEDIATRICS (2022)

Article Emergency Medicine

Association Between the First-Hour Intravenous Fluid Volume and Mortality in Pediatric Septic Shock

Matthew A. Eisenberg et al.

Summary: This study aimed to investigate whether receiving more than or equal to 30 mL/kg of intravenous fluid in the first hour after arrival at the emergency department (ED) is associated with sepsis-attributable mortality in children with hypotensive septic shock. The study found that receiving more than or equal to 30 mL/kg of fluid in the first hour after arrival at the ED was not associated with mortality in children with hypotensive septic shock.

ANNALS OF EMERGENCY MEDICINE (2022)

Article Critical Care Medicine

Association of Pathogen Type With Outcomes of Children Encountering Community-Acquired Pediatric Septic Shock

Derek Salud et al.

Summary: This study analyzed the association between pathogen type and mortality, functional status, and health-related quality of life in children with septic shock. The results showed no significant association between pathogen type and composite mortality and morbidity outcomes, but there may be an association with PICU resources employed for treating organ dysfunction.

PEDIATRIC CRITICAL CARE MEDICINE (2022)

Article Pediatrics

Development of a Quality Improvement Learning Collaborative to Improve Pediatric Sepsis Outcomes

Gitte Y. Larsen et al.

Summary: Pediatric sepsis is a significant public health issue, and the Children's Hospital Association's IPSO collaborative aims to improve patient outcomes through collaborative learning and implementation of evidence-based interventions to address the complexity of pediatric sepsis.

PEDIATRICS (2021)

Article Medicine, Research & Experimental

PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial

Scott L. Weiss et al.

Summary: The study aims to compare the effects of using balanced/buffered fluids and 0.9% saline for initial fluid management in children with septic shock, focusing primarily on adverse events such as kidney injury and death.

TRIALS (2021)

Article Pediatrics

Metric Development for the Multicenter Improving Pediatric Sepsis Outcomes (IPSO) Collaborative

Raina Paul et al.

Summary: The Improving Pediatric Sepsis Outcomes collaborative has developed variables, metrics, and a data analysis plan to track QI-based patient outcomes, expanding on previous efforts by improving data capture and uniformity. An expert panel developed metrics and variables to assess improvements in care delivery, with 24 evidence-based metrics reflecting timely interventions for a defined sepsis cohort. A comprehensive data dictionary was developed, optimizing automation and ensuring sustainable reporting for large-scale sepsis QI projects.

PEDIATRICS (2021)

Review Critical Care Medicine

Comparison of culture-negative and culture-positive sepsis or septic shock: a systematic review and meta-analysis

Yuting Li et al.

Summary: This systematic review and meta-analysis found that culture positivity or negativity is not associated with mortality in patients with sepsis or septic shock. Additionally, culture-positive patients had longer hospital stays and mechanical ventilation durations compared to culture-negative patients. Further large-scale studies are needed to confirm these findings.

CRITICAL CARE (2021)

Article Critical Care Medicine

Characteristics and clinical outcomes of culture-negative and culture-positive septic shock: a single-center retrospective cohort study

June-sung Kim et al.

Summary: The study found that a significant proportion of patients with septic shock have culture-negative infections, especially in cases of lower respiratory tract infections. While culture-negative infections were associated with some degree of organ dysfunction, they were not an independent predictor of mortality.

CRITICAL CARE (2021)

Article Immunology

Two Blood Cultures With Age-Appropriate Volume Enhance Suspected Sepsis Decision-Making

Paul Tran et al.

OPEN FORUM INFECTIOUS DISEASES (2020)

Article Medicine, General & Internal

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

Christopher W. Seymour et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Article Infectious Diseases

Assessment and comparison of bacterial load levels determined by quantitative amplifications in blood culture-positive and negative neonatal sepsis

Ines Stranieri et al.

REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO (2018)

Article Critical Care Medicine

The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die

Scott L. Weiss et al.

PEDIATRIC CRITICAL CARE MEDICINE (2017)

Article Critical Care Medicine

Culture-Negative Severe Sepsis Nationwide Trends and Outcomes

Shipra Gupta et al.

Article Critical Care Medicine

Global Epidemiology of Pediatric Severe Sepsis: The Sepsis Prevalence, Outcomes, and Therapies Study

Scott L. Weiss et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Article Critical Care Medicine

Delayed Antimicrobial Therapy Increases Mortality and Organ Dysfunction Duration in Pediatric Sepsis

Scott L. Weiss et al.

CRITICAL CARE MEDICINE (2014)

Article Critical Care Medicine

Pediatric Severe Sepsis: Current Trends and Outcomes From the Pediatric Health Information Systems Database

Amanda Ruth et al.

PEDIATRIC CRITICAL CARE MEDICINE (2014)

Article Critical Care Medicine

Trends in the Epidemiology of Pediatric Severe Sepsis

Mary E. Hartman et al.

PEDIATRIC CRITICAL CARE MEDICINE (2013)

Article Critical Care Medicine

Characteristics and outcomes of culture-negative versus culture-positive severe sepsis

Jason Phua et al.

CRITICAL CARE (2013)