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Summary: This study investigated the combined effect of omega-3 long-chain polyunsaturated fatty acids (EPA and DHA) and cocoa flavanols on cognitive performance and brain structures in older adults with memory complaints. The results showed that this intervention did not improve cognitive outcomes but led to negative effects, such as increased reaction time variability, decreased alertness and executive function, and a decrease in cortical volume.

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BMC NEUROLOGY (2021)

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Subjective cognitive decline: opposite links to neurodegeneration across the Alzheimer's continuum

Elizabeth Kuhn et al.

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BRAIN COMMUNICATIONS (2021)

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Volume reduction of the entorhinal cortex in subjective memory impairment

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NEUROBIOLOGY OF AGING (2006)