期刊
AMERICAN JOURNAL OF CARDIOLOGY
卷 206, 期 -, 页码 -出版社
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjcard.2023.08.092
关键词
hypertrophic cardiomyopathy; mitral valve prolapse; outcomes
Obstructive hypertrophic cardiomyopathy (oHCM) and mitral valve (MV) prolapse (MVP) are two conditions that can cause symptomatic heart failure and sudden cardiac death. This study investigated the clinical characteristics and surgical outcomes of patients with oHCM and MVP. Patients with MVP had more severe symptoms and higher incidence of mitral regurgitation, atrial fibrillation, and ventricular tachycardia. Surgery combining mitral valve repair or replacement with myectomy effectively relieved left ventricular outflow tract gradients and mitral regurgitation.
Obstructive hypertrophic cardiomyopathy (oHCM) and mitral valve (MV) prolapse (MVP) are the 2 conditions which could cause symptomatic heart failure and sudden cardiac death. The clinical characteristics and surgical outcomes of patients with oHCM and MVP have not been well reported. From April 2012 to February 2018, 84 patients with oHCM (28 patients with MVP and 56 gender-and age-matched patients without MVP) who underwent septal myectomy at our institution were enrolled in this study. Information on clinical characteristics and outcomes was obtained from electronic medical records and follow-up surveys. Compared with those without MVP, patients with MVP were more symptomatic (New York Heart Association class III to IV; 96% vs 77%), more often moderate-to-severe mitral regurgitation (86% vs 48%), atrial fibrillation (39% vs 11%) and higher incidence of nonsustained ventricular tachycardia (44% vs 15%). Twenty (71%) had MV repair and 8 (29%) had MV replacement. Compared with patients without MVP, those with MVP had a longer postoperative hospital stay (10.9 +/- 6.4 vs 7.8 +/- 2.8 days). None of the 84 study patients died during hospital or follow-up. At the most recent echo -cardiographic evaluation, left ventricular outflow tract gradient significantly decreased from 69.7 +/- 35.4 millimeters of mercury to 7.3 +/- 5.1 millimeters of mercury and the degree of mitral valve regurgitation improved from grade 2.43 +/- 0.69 to grade 0.5 +/- 0.69. In conclusion, MVP occurs rarely in oHCM, and was related to atrial fibrillation, ventricular arrhythmia and mitral regurgitation. Mitral valve surgery in combination with myectomy is effective and safe for patients with oHCM and MVP, relieving substantially left ventricular outflow tract gradients and mitral regurgitation.(c) 2023 Elsevier Inc. All rights reserved.
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