Pulmonary Hypertension Severity in Heart Failure: Clinical Characteristics and Impact on Outcome

Article Cardiac & Cardiovascular Systems

Combined pre- and post-capillary pulmonary hypertension in left heart disease

M. Riccardi et al.

Summary: Patients with heart failure often develop pulmonary hypertension, which can be a combination of post-capillary and pre-capillary types. The exact mechanisms leading to this combined type are not clear, but it involves increased pressure transmission and remodeling of the alveolar and vascular components. The predisposing factors for this disease are still unknown. Echocardiography parameters and scoring systems can help differentiate between idiopathic pulmonary arterial hypertension and combined pulmonary hypertension and guide treatment decisions.

HEART FAILURE REVIEWS (2023)

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Article Cardiac & Cardiovascular Systems

Elucidating the Clinical Implications and Pathophysiology of Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction: A Call to Action: A Science Advisory From the American Heart Association

Evan L. Brittain et al.

Summary: This article emphasizes the importance of pulmonary hypertension in patients with heart failure with preserved ejection fraction and suggests areas for further research, including hemodynamics, disease definitions, pathophysiology, and treatment directions.

CIRCULATION (2022)

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Article Cardiac & Cardiovascular Systems

Meta-analysis of echocardiographic quantification of left ventricular filling pressure

Rachel Jones et al.

Summary: The study evaluated the effectiveness of different echocardiographic indices in estimating true LVFP and found a moderate pooled association with invasively measured LVFP, which varied widely with disease state. In heart failure with preserved ejection fraction, no single echocardiography-based metric offered a reliable estimate, while in heart failure with reduced ejection fraction, mitral inflow-derived indices showed reasonable clinical applicability. An integrated approach using multiple echocardiographic metrics shows promise for reliably estimating LVFP, but further validation in larger patient-specific studies is needed.

ESC HEART FAILURE (2021)

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Article Critical Care Medicine