CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis

Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)(+) T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA(+) T cell mechanisms in atopic dermatitis patients. The function of CLA(+) T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.

Automated summary

CLA(+)T cells, a small subset of memory T cells, are involved in various aspects of atopic dermatitis, including Staphylococcus aureus related mechanisms, abnormal Th2 immune response, biomarkers, clinical aspects, pruritus, and targeted therapies. These cells correspond to the function of T cells in the skin-associated lymphoid tissue and reflect different mechanisms of atopic dermatitis and other T cell mediated skin diseases. The review aims to gather all translational information on atopic dermatitis pathology.