Granzyme B production by Th2 helper and NK cells improves the LTT test in patients with non-immediate drug hypersensitivity reactions

Article Allergy

Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy

Justine Calise et al.

Summary: This study found that inherent qualities of cell response at baseline can influence the response to peanut oral immunotherapy in peanut-allergic individuals. Peanut allergy can be broadly classified into at least two subtypes based on the proportion of specific T-cell subsets, with distinct immunologic and clinical characteristics. Stratifying patients based on their peanut-specific T-cell profile may help identify which immunotypes will respond best to different therapies in clinical settings.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2023)

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Review Allergy

Advances and highlights in T and B cell responses to drug antigens

Ruben Fernandez-Santamaria et al.

Summary: The immunological mechanisms involved in drug hypersensitivity reactions are complex and not fully understood. Recent advances have highlighted new evidences of interactions between drug antigen and proteins, the role of oxidative metabolism of drugs in activating the immune system, and associations between DHRs and HLA variants, advancing precision in diagnosis, management, and treatment of DHRs.

ALLERGY (2022)

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Review Allergy

The complexity of T cell-mediated penicillin hypersensitivity reactions

Shawn J. R. Goh et al.

Summary: Penicillin, as a first-line treatment for infections, can induce immune-mediated adverse reactions including IgE-mediated and non-IgE-mediated reactions, manifesting as skin eruptions and liver injury. Studies have shown that the infiltration of T cells at the site of inflammation is dependent on the nature of the reaction.

ALLERGY (2021)

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Article Allergy

Dendritic cells inclusion and cell-subset assessment improve flow-cytometry-based proliferation test in non-immediate drug hypersensitivity reactions

Ruben Fernandez-Santamaria et al.

Summary: This study utilized drug-primed DCs and the proliferative response of different lymphocyte subpopulations to significantly improve the diagnostic sensitivity of NIDHRs, particularly in specific clinical entities. The use of flow-cytometry-based test focusing on effector cell subpopulations for each clinical entity led to enhanced drug-specific proliferative response in NIDHRs with a unique cellular in vitro test.

ALLERGY (2021)

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Editorial Material Allergy

Drug hypersensitivity: We need to do more

Werner J. Pichler et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Allergy

β-Lactam hypersensitivity involves expansion of circulating and skin-resident TH22 cells

Andrew Sullivan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Granzyme B production by Th2 helper and NK cells improves the LTT test in patients with non-immediate drug hypersensitivity reactions

相关参考文献

Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy

Advances and highlights in T and B cell responses to drug antigens

The complexity of T cell-mediated penicillin hypersensitivity reactions

Dendritic cells inclusion and cell-subset assessment improve flow-cytometry-based proliferation test in non-immediate drug hypersensitivity reactions

Drug hypersensitivity: We need to do more

β-Lactam hypersensitivity involves expansion of circulating and skin-resident TH22 cells

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