期刊
AGING CELL
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1111/acel.13962
关键词
9p21; age-related disease; aging; centenarians; longevity; population genomics
Genome-wide association studies have identified the chromosomal locus 9p21.3 as a genetic hotspot for age-related disorders. In this study, the sequencing of this region in an Ashkenazi Jewish centenarian cohort revealed a significant depletion of risk alleles associated with various diseases. The findings suggest that the extreme longevity cohort may have collectively lower risks of multiple age-related diseases in the 9p21.3 locus.
Genome-wide association studies (GWAS) have pinpointed the chromosomal locus 9p21.3 as a genetic hotspot for various age-related disorders. Common genetic variants in this locus are linked to multiple traits, including coronary artery diseases, cancers, and diabetes. Centenarians are known for their reduced risk and delayed onset of these conditions. To investigate whether this evasion of disease risks involves diminished genetic risks in the 9p21.3 locus, we sequenced this region in an Ashkenazi Jewish centenarian cohort (centenarians: n = 450, healthy controls: n = 500). Risk alleles associated with cancers, glaucoma, CAD, and T2D showed a significant depletion in centenarians. Furthermore, the risk and non-risk genotypes are linked to two distinct low-frequency variant profiles, enriched in controls and centenarians, respectively. Our findings provide evidence that the extreme longevity cohort is associated with collectively lower risks of multiple age-related diseases in the 9p21.3 locus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据