Prevention and treatment of inflammatory arthritis with traditional Chinese medicine: Underlying mechanisms based on cell and molecular targets

Article Plant Sciences

Gancao Fuzi decoction regulates the Th17/Treg cell imbalance in rheumatoid arthritis by targeting Foxp3 via miR-34a

Xiaoshan Zhao et al.

Summary: This study demonstrates the therapeutic effect of GCFZD on mice with CIA, and the mechanism is related to an improvement in the Th17/Treg cell imbalance by targeting Foxp3 via miR-34a.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Article Plant Sciences

Wutou decoction attenuates the synovial inflammation of collagen-induced arthritis rats via regulating macrophage M1/M2 type polarization

Weiji Lin et al.

Summary: Wutou decoction (WTD) can alleviate synovial inflammation in rheumatoid arthritis (RA) by regulating macrophage polarization.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Article Plant Sciences

6-Shogaol inhibits the proliferation, apoptosis, and migration of rheumatoid arthritis fibroblast-like synoviocytes via the PI3K/AKT/NF-κB pathway

Nan Li et al.

Summary: This study found that 6-shogaol inhibits proliferation, migration, and invasion, and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes (FLSs). It also reduces the production of inflammatory cytokines and matrix metalloproteinases (MMPs). Molecular mechanism analysis revealed that 6-shogaol inhibits the PI3K/AKT/NF-kappa B pathway by activating PPAR-gamma. Treatment with 6-shogaol ameliorated joint destruction in a mouse model of collagen-induced arthritis (CIA). Therefore, 6-shogaol may be a potential natural drug for future rheumatoid arthritis treatments.

PHYTOMEDICINE (2023)

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Article Plant Sciences

Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats

Kuangyang Yang et al.

Summary: In this study, the researchers found that Astragaloside IV (ASN IV), a phytochemical found in Astragalus membranaceus, acts as a novel CXCR4 antagonist, protecting cartilage in osteoarthritis (OA) patients. ASN IV inhibits the overexpression of ADAMTS4,5 in chondrocytes by blocking Akt signaling pathway. Furthermore, ASN IV administration repairs damaged cartilage and subchondral bone in an animal model of OA. This study suggests that repurposing ASN IV as a joint protective agent could be a promising strategy for OA drug development.

PHYTOMEDICINE (2023)

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Article Plant Sciences

Simiao Yong'an decoction ameliorates murine collagen-induced arthritis by modulating neutrophil activities: An in vitro and in vivo study

Shan-shan Jie et al.

Summary: Traditional Chinese prescription SMYAD has remarkable anti-inflammatory properties and effectively relieves arthritis in rheumatoid arthritis (RA) mice by modulating neutrophil activities.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Article Chemistry, Medicinal

Tanshinone IIA relieves arthritis by inhibiting autophagy of fibroblast-like synoviocytes via matrix metalloproteinase9/receptor for advanced glycation end product/toll-like receptor 9 signal axis in mice with collagen-induced arthritis

Wei Liu et al.

Summary: In this study, the researchers investigated the mechanisms by which Tanshinone IIA (TIIA) affects RA fibroblast-like synoviocytes (RA-FLSs). They used a mouse model of RA called collagen-induced arthritis (CIA) and manipulated matrix metalloproteinase9 (MMP9), receptor for advanced glycation end product (RAGE), and toll-like receptor 9 (TLR9) in both mice and RA-FLSs to study the effects of TIIA. The results showed that TIIA inhibited the proliferation of RA-FLSs, affected autophagy, and improved the symptoms of RA in mice by inhibiting the expression of MMP9 and the activation of TLR9 via the RAGE pathway.

PHYTOTHERAPY RESEARCH (2023)

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Review Integrative & Complementary Medicine

Efficacy and safety of Duhuo Jisheng decoction combined with Western medicine in the treatment of ankylosing spondylitis: A systematic review and meta-analysis

Renhong Wan et al.

Summary: This study aimed to assess the efficacy and safety of Duhuo Jisheng Decoction (DJD) combined with Western medicine in treating ankylosing spondylitis (AS). The results of the meta-analysis indicated that compared to Western medicine alone, the combinational use of DJD and Western medicine resulted in significantly higher effective rate, functional scores, and symptom improvement, with a reduced rate of adverse reactions.

COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE (2023)

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Article Plant Sciences

Toddalia asiatica extract attenuates adjuvant-induced arthritis by modulating colon Th17/Treg balance and colony homeostasis

Huangguan Qin et al.

Summary: The study shows that Toddalia asiatica extract (TAE) can effectively treat rheumatoid arthritis (RA) in rats by modulating intestinal immunity and the gut microbiota.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

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Article Mathematical & Computational Biology

Analysis of Clinical Efficacy of Clearing Heat and Dispelling Paralysis Soup in the Treatment of Osteoarthritis of the Knee Joint and Its Effect on Patients' Motor Function

Lihu Xie et al.

Summary: Combined treatment with Qinghe dispel paralysis soup can improve the motor function of the knee joint, reduce the level of inflammation in the organism, and has high safety and effectiveness.

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE (2022)

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Article Pharmacology & Pharmacy

The immunomodulatory effect of koumine on B cells under dependent and independent responses by T cells

Yarong Lin et al.

Summary: Koumine has both direct and indirect immunomodulatory effects on B cells, inhibiting their differentiation, activation, and proliferation, and reducing antibody secretion. This may be an important mechanism for its anti-rheumatoid arthritis effect.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article

Tetrandrine Ameliorates Rheumatoid Arthritis in Mice by Alleviating Neutrophil Activities

Qingyi Lu et al.

Evidence-based Complementary and Alternative Medicine (2022)

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Article Integrative & Complementary Medicine

Wu-Teng-Gao External Treatment Improves Th17/Treg Balance in Rheumatoid Arthritis

Xueming Yao et al.

Summary: WTG, a traditional Chinese medicine formula, has been widely used to treat rheumatoid arthritis (RA) in China. This study used a network pharmacological approach and in vitro experiments to explore the mechanisms of WTG in RA treatment. The results showed that WTG could alleviate articular inflammation and inhibit the destruction of articular cartilage by regulating the differentiation of Th17/Treg cells.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Cell Biology

Cinnamic Aldehyde, the main monomer component of Cinnamon, exhibits anti-inflammatory property in OA synovial fibroblasts via TLR4/MyD88 pathway

Pu Chen et al.

Summary: This study investigated the mechanism of cinnamic aldehyde (CA), a bioactive substance extracted from Cinnamon, on synovial inflammation in osteoarthritis (OA). The results demonstrated that CA exhibited strong anti-inflammation effect in OA fibroblast-like synoviocytes (FLS) through blocking the activation of TLR4/MyD88 signalling pathway, indicating its potential as a hopeful candidate for the development of novel agents for the treatment of OA.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Pharmacology & Pharmacy

Wilforlide A ameliorates the progression of rheumatoid arthritis by inhibiting M1 macrophage polarization

Yunxiang Cao et al.

Summary: Wilforlide A ameliorates M1 macrophage polarization in rheumatoid arthritis (RA) by inhibiting TLR4/NF-kappa B signaling pathway, reducing clinical symptoms in collagen-induced arthritis (CIA) mice, and suppressing pro-inflammatory factors secretion.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

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Review Cell Biology

The Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Knee Osteoarthritis: An Updated Systematic Review and Meta-Analysis of 56 Randomized Controlled Trials

Zhou Lin et al.

Summary: This systematic review and meta-analysis found that Chinese herbal medicine can effectively reduce pain and improve the quality of life in patients with knee osteoarthritis. It also demonstrated that Chinese herbal medicine is safe and well tolerated. However, further high-quality studies are needed to confirm these findings due to heterogeneity and limited sample size.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Plant Sciences

Dendrobine attenuates osteoclast differentiation through modulating ROS/NFATc1/MMP9 pathway and prevents inflammatory bone destruction

Wende Deng et al.

Summary: This study found that dendrobine can alleviate inflammatory osteolysis by inhibiting osteoclastogenesis and bone resorption. In vitro experiments showed that dendrobine exerted its effects by suppressing ROS, p38-c-Fos, and NFATc1-MMP9. In vivo experiments showed that oral administration of dendrobine prevented LPS-induced osteolysis.

PHYTOMEDICINE (2022)

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Article Medicine, General & Internal

Catalpol Inhibits Tregs-to-Th17 Cell Transdifferentiation by Up-Regulating Let-7g-5p to Reduce STAT3 Protein Levels

Yuxi Di et al.

Summary: In this study, we found that CAT suppresses Tregs-to-Th17 cells transdifferentiation by up-regulating let-7g-5p, providing a new direction for research into RA treatment.

YONSEI MEDICAL JOURNAL (2022)

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Article Nutrition & Dietetics

An Investigation into the Effects of a Curcumin Extract (Curcugen(R)) on Osteoarthritis Pain of the Knee: A Randomised, Double-Blind, Placebo-Controlled Study

Adrian L. Lopresti et al.

Summary: Curcumin may have the potential to alleviate pain in knee osteoarthritis, as it significantly reduces pain scores and improves physical function. However, further studies with longer duration, varying doses, different curcumin extracts, and more objective outcome measures are needed to confirm these findings.

NUTRIENTS (2022)

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Article Materials Science, Biomaterials

Folate-modified triptolide liposomes target activated macrophages for safe rheumatoid arthritis therapy

Rui-Bo Guo et al.

Summary: The folate-modified triptolide liposomes designed in this study showed specific targeting effects in treating RA and demonstrated low cytotoxicity and significant anti-inflammatory properties in vitro. In vivo experiments also indicated good cartilage protection and anti-inflammatory effects with lower toxicity compared to free triptolide, providing a promising new approach for RA treatment.

BIOMATERIALS SCIENCE (2022)

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Article Biotechnology & Applied Microbiology

Columbianetin alleviates lipopolysaccharides (LPS)-induced inflammation and apoptosis in chondrocyte through activation of autophagy by inhibiting serum and glucocorticoid-induced protein kinase 1 (SGK1) expression

Wei Chen et al.

Summary: This study found that CBT can improve osteoarthritis by suppressing SGK1 expression and activating chondrocyte autophagy. CBT enhances ATDC5 cell viability, inhibits inflammation, and attenuates cell apoptosis induced by LPS. Additionally, CBT regulates the expression of autophagy-related proteins.

BIOENGINEERED (2022)

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Editorial Material Multidisciplinary Sciences

Modulating gut microbiota in autoimmune diseases: a cutting-edge strategy from prophylaxis to therapeutics

Min Wang et al.

SCIENCE BULLETIN (2022)

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Article Medicine, General & Internal

Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression

Yu Miao et al.

Summary: This study demonstrated the presence of ferroptosis in osteoarthritis (OA) and identified glutathione peroxidase 4 (GPX4) as a crucial regulator of OA. By downregulating GPX4 expression, the crosstalk between ferroptosis and extracellular matrix degradation pathways influenced the progression of OA.

EBIOMEDICINE (2022)

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Article Oncology

The method of Yiqi Yangyin Tongluo can attenuate the pyroptosis of rheumatoid arthritis chondrocytes through the ASIC1a/NLRP3 signaling pathway

Yeyu Zhao et al.

Summary: The method of nourishing qi, nourishing yin, and dredging collaterals can attenuate the pyroptosis of RA chondrocytes through the ASIC1a/NLRP3 signaling pathway.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Article Chemistry, Multidisciplinary

Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion

Chao Fang et al.

Summary: This study demonstrated that diterbutyl phthalate (DP) from Panax notoginseng inhibits abnormal osteoclastogenesis in subchondral bone, thereby preventing progression of osteoarthritis in a mouse model. DP treatment reduced articular cartilage degeneration and neurogenesis, leading to alleviation of OA pain.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Pharmacology & Pharmacy

Delivery of germacrone (GER) using macrophages-targeted polymeric nanoparticles and its application in rheumatoid arthritis

Tingfei Tan et al.

Summary: Macrophages can transform into M1 and M2 phenotypes, which play important roles in the immune/inflammatory response in rheumatoid arthritis (RA). In this study, a macrophage-targeting nanocarrier loaded with germacrone (GER) was developed to reverse proinflammatory cells and reduce inflammation in RA. The results showed that the nanocarrier significantly promoted the transformation of M1 macrophages into M2 macrophages and exhibited a significant therapeutic effect in an animal model of RA.

DRUG DELIVERY (2022)

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Article Integrative & Complementary Medicine

Total Saponins of Radix Clematis Regulate Fibroblast-Like Synoviocyte Proliferation in Rheumatoid Arthritis via the LncRNA OIP5-AS1/MiR-410-3p/Wnt7b Signaling Pathway

Lingyu Pan et al.

Summary: This study found that total saponins of Radix clematidis (TSC) can inhibit the proliferation of rheumatoid arthritis (RA) synovial cells, and exert therapeutic effects by regulating the lncRNA OIP5-AS1/miR-410-3p/Wnt7b signaling pathway and the Wnt signaling pathway.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

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Article Plant Sciences

Fengshi Qutong capsule ameliorates bone destruction of experimental rheumatoid arthritis by inhibiting osteoclastogenesis

Yiqun Li et al.

Summary: FSQTC has been shown to significantly increase bone mineral density, volume fraction, and trabecular thickness, and decrease trabecular separation in inflamed joints of CIA rats. Treatment with FSQTC also reduced the level of CTX-I and increased osteocalcin in sera of CIA rats. Furthermore, FSQTC inhibited osteoclast differentiation, bone resorption, and expression of osteoclastic markers in joints. Additionally, FSQTC reduced the level of RANKL, increased OPG expression, and decreased the ratio of RANKL to OPG, as well as inhibiting pro-inflammatory cytokines in sera. Moreover, FSQTC inhibited formation of osteoclasts and related gene/protein expression in RANKL-induced RAW264.7 cells by targeting MAPK signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Plant Sciences

Efficacy and safety of Fengshi Gutong Capsule in patients with active ankylosing spondylitis: A 4-week randomized controlled, double-blinded, double-dummy trial

Ya Xie et al.

Summary: This study found that Fengshi Gutong Capsule (FSGTC) alone or in combination with NSAIDs has therapeutic efficacy in treating patients with active ankylosing spondylitis, with good gastrointestinal tolerability after 4 weeks of treatment.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Biology

Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-kappa B signaling pathway

Gaoran Ge et al.

Summary: The study revealed that punicalagin could ameliorate pathological inflammation in rheumatoid arthritis by modulating macrophage polarization and inhibiting pyroptosis, suggesting its great potential as a therapeutic treatment for human RA.

SCIENCE CHINA-LIFE SCIENCES (2022)

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Article Plant Sciences

Effect of Er Miao San on peritoneal macrophage polarisation through the miRNA-33/NLRP3 signalling pathway in a rat model of adjuvant arthritis

Min Liu et al.

Summary: In this study, it was found that Er Miao San (EMS) treatment could reduce macrophage polarization to the M1 inflammatory phenotype by downregulating the miRNA-33/NLRP3 pathway in rats with adjuvant arthritis (AA). EMS also increased the levels of anti-inflammatory cytokines IL-10 and TGF-beta, and decreased the levels of pro-inflammatory cytokines IL-1 beta and TNF-alpha.

PHARMACEUTICAL BIOLOGY (2022)

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Review Plant Sciences

Efficacy and Safety of Chinese Herbal Medicine for Knee Osteoarthritis: Systematic Review and Meta-analysis of Randomized Controlled Trials

Qing Wang et al.

Summary: This study systematically evaluated the effectiveness and safety of oral Chinese herbal medicine (CHM) in the treatment of knee osteoarthritis (KOA). The results showed that CHM was more effective than placebo and Western medicine in the treatment of KOA. Additionally, the combination of CHM and Western medicine was superior to Western medicine alone. However, due to biases in the included studies and the need for further research on the effective components of Chinese medicine, a definitive conclusion on the efficacy of traditional CHM in treating KOA cannot be drawn and requires confirmation through high-quality clinical trials.

PHYTOMEDICINE (2022)

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Article Health Care Sciences & Services

Clinical Effect of Bushen Huoxue Method Combined with Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis and Its Effect on IL-1, IL-6, VEGF, and PGE-2

Zhengwen Sun et al.

Summary: This study observed the clinical efficacy of the Bushen Huoxue method combined with platelet-rich plasma (PRP) in the treatment of knee osteoarthritis (KOA) and its impact on serum and joint fluid interleukin-1 (IL-1), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE-2). The results showed that the combination therapy had a higher clinical effectiveness rate compared to PRP alone, with lower osteoarthritis index scores and pain visual analogue scores. Furthermore, the levels of IL-1, IL-6, and PGE-2 in serum and joint fluid were lower in the combination therapy group. Therefore, the combination of PRP and the Bushen Huoxue method can effectively improve the treatment of KOA.

JOURNAL OF HEALTHCARE ENGINEERING (2022)

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Article Biotechnology & Applied Microbiology

Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis

Jianwei Xiao et al.

Summary: Curcumin protects against arthritis by regulating the inc00052/miR-126-5p/PIAS2 axis through the JAK2/STAT3 signaling pathway.

BIOENGINEERED (2022)

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Article Plant Sciences

Ershiwuwei Lvxue Pill alleviates rheumatoid arthritis by different pathways and produces changes in the gut microbiota

Yangxin Li et al.

Summary: This study aims to elucidate the mechanism of action of Ershiwuwei Lvxue Pill (ELP) in improving rheumatoid arthritis (RA) joint damage. The results showed that ELP alleviates cartilage and bone injury by inhibiting matrix metalloproteinases (MMPs) production and osteoclast activity. Additionally, ELP regulates the composition of gut microbiota and host metabolites. This study provides a novel insight into the potential therapeutic effects of ELP in RA.

PHYTOMEDICINE (2022)

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Article Plant Sciences

The efficacy and safety of Jinwu Gutong capsule in the treatment of knee osteoarthritis: A meta-analysis of randomized controlled trials

Jinlong Zhao et al.

Summary: The Jinwu Gutong capsule showed good clinical efficacy and safety in treating knee osteoarthritis, and could significantly improve the treatment efficacy when combined with NSAIDs, hyaluronic acid, or glucosamine.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Immunology

Xiong Fu Powder Regulates the Intestinal Microenvironment to Protect Bones Against Destruction in Collagen-Induced Arthritis Rat Models

Xiaoyu Xi et al.

Summary: The aggravation of spleen deficiency (SD) on collagen-induced arthritis (CIA) and the bone protection of compound Xiong Fu powder (XFP) on SD-CIA were explored based on the intestinal microenvironment. Results showed that SD could exacerbate bone destruction in CIA rats, while XFP treatment improved bone damage and intestinal mucosal immune disorders in SD-CIA rats by regulating the intestinal microenvironment.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Article Orthopedics

Total Knee Arthroplasty Using Adjusted Restricted Kinematic Alignment for the Treatment of Severe Varus Deformity: Technical Note

Kai Zheng et al.

Summary: The new alignment technique of arKA aims to treat severe varus deformity through balancing the extension and flexion gap, restoring the native pre-arthritic alignment, which may be a promising alignment strategy for severe varus deformity. Further studies and comparisons with other alignment techniques are needed to confirm its effectiveness.

ORTHOPAEDIC SURGERY (2022)

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Article Chemistry, Multidisciplinary

Injectable Amphipathic Artesunate Prodrug-Hydrogel Microsphere as Gene/Drug Nano-Microplex for Rheumatoid Arthritis Therapy

Chao Li et al.

Summary: In this study, a gene/artemisinin co-delivery nanomicroplex is developed for the treatment of rheumatoid arthritis (RA). Through intra-articular injection, the sustained activity of gene therapy and long-term efficacy of artemisinin are realized.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Review Chemistry, Multidisciplinary

Nanoemulsion applications in photodynamic therapy

Saeid Moghassemi et al.

Summary: Nanoemulsion, a stable system formed by blending two immiscible liquids and an emulsifying agent, has shown great potential in various fields. In photodynamic therapy, nanoemulsion-loaded photosensitizing agents can overcome limitations of common photosensitizers and provide an effective drug delivery technology.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Integrative & Complementary Medicine

Chrysoeriol suppresses hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes and inhibits JAK2/STAT3 signaling

Jia-Ying Wu et al.

Summary: The study demonstrates that chrysoeriol suppresses the hyperproliferation of RA-FLS and induces apoptosis. This is achieved by inhibiting the JAK2/STAT3 signaling pathway and downregulating the expression of Bcl-2 and Mcl-1.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2022)

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Article Rheumatology

Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression

Ming-Feng Hsueh et al.

Summary: The study evaluated the role of immune cells and cytokines in the pathogenesis and progression of knee osteoarthritis. The results showed that concentrations of elastase and TGF-beta 1 in SF were associated with the severity of OA progression, indicating their predictive potential for disease progression.

ARTHRITIS & RHEUMATOLOGY (2021)

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Article Chemistry, Medicinal

Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial

Lorena Calderon-Perez et al.

Summary: Turmeric extracts have been found to have short-term analgesic effects on knee joint pain, reducing pain and inflammation.

JOURNAL OF MEDICINAL FOOD (2021)

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Article Chemistry, Medicinal

Effects of sinomenine on the proliferation, cytokine production, and regulatory T-cell frequency in peripheral blood mononuclear cells of rheumatoid arthritis patients

Wencheng Xu et al.

Summary: The study suggests that Sinomenine may not exert its anti-rheumatoid arthritis mechanism through suppression of peripheral T cells.

DRUG DEVELOPMENT RESEARCH (2021)

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Article Chemistry, Medicinal

The effect of black barberry hydroalcoholic extract on immune mediators in patients with active rheumatoid arthritis: A randomized, double-blind, controlled clinical trial

Naheed Aryaeian et al.

Summary: Black barberry extract may alleviate the severity of rheumatoid arthritis, decrease IL-17 levels, and increase IL-10 levels, showing a potential for modulating inflammation and enhancing anti-inflammatory effects in RA.

PHYTOTHERAPY RESEARCH (2021)

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Article Engineering, Biomedical

3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model

Yanzhi Liu et al.

Summary: This study developed a BMSC-laden scaffold capable of inhibiting joint inflammation and promoting cartilage defect repair simultaneously. In animal experiments, the scaffold was found to enhance chondrogenesis and significantly improve joint function in the injured leg.

BIOMATERIALS (2021)

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Article Cell Biology

Umbelliferone Ameliorates Complete Freund Adjuvant-Induced Arthritis via Reduction of NF-κB Signaling Pathway in Osteoclast Differentiation

Guofeng Wu et al.

Summary: In this study, umbelliferone was found to have a significant inhibitory effect on the CFA-induced rheumatoid arthritis model, reducing joint swelling and increasing body weight. Additionally, umbelliferone significantly reduced osteoclast numbers by modulating the RANKL/RANK/OPG ratio.

INFLAMMATION (2021)

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Article Pharmacology & Pharmacy

Icariin arrests cell cycle progression and induces cell apoptosis through the mitochondrial pathway in human fibroblast-like synoviocytes

Luya Pu et al.

Summary: Icariin can inhibit the proliferation of FLSs by interfering with the cell cycle process and inducing cell apoptosis, indicating its potential for the treatment of RA.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Immunology

Triptolide decreases rheumatoid arthritis fibroblast-like synoviocyte proliferation, invasion, inflammation and presents a therapeutic effect in collagen-induced arthritis rats via inactivating lncRNA RP11-83J16.1 mediated URI1 and ll-catenin signaling

Xuemei Piao et al.

Summary: The study demonstrated that triptolide inhibits the expression of lncRNA RP11-83J16.1, reducing cell proliferation and inflammation in the treatment of rheumatoid arthritis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

B Cell Involvement in the Pathogenesis of Ankylosing Spondylitis

Rick Wilbrink et al.

Summary: Research suggests that genetics, immune reactions, and the joint-gut axis play major roles in the etiology of ankylosing spondylitis (AS). While B cells have been traditionally understudied in AS pathogenesis, increasing evidence points to their involvement, with disturbances in B cell populations and the formation of antibodies seen in AS patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biotechnology & Applied Microbiology

Shentong Zhuyu Decoction Inhibits Inflammatory Response, Migration, and Invasion and Promotes Apoptosis of Rheumatoid Arthritis Fibroblast-like Synoviocytes via the MAPK p38/PPARγ/CTGF Pathway

Ying Han et al.

Summary: The study demonstrated that Shentong Zhuyu Decoction inhibited the proliferation, migration, invasion, and transition of RA-FLS through the MAPK p38/PPAR gamma/CTGF pathway and promoted apoptosis.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Plant Sciences

Chinese herbal medicine might be associated with a lower rate of joint replacement in patients with osteoarthritis: A 12-year population-based matched cohort analysis

Yu-Min Cho et al.

Summary: This study showed that adjuvant Chinese herbal medicine (CHM) might be associated with a lower risk of joint replacement in osteoarthritis (OA) patients, especially among younger users. However, this benefit was not observed in older OA patients. CHM therapy could be considered for OA patients to reduce the need for joint replacement.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Traditional herbal medicine: Therapeutic potential in rheumatoid arthritis

Yuan Wang et al.

Summary: Traditional herbal medicines (THMs) have potential pharmacological mechanisms in the treatment of rheumatoid arthritis (RA), with main components including flavonoids, phenolic acids, alkaloids, and triterpenes. THMs can alleviate symptoms of RA through regulating multiple therapeutic targets such as immunity, inflammation, microRNAs, etc. Further research is needed to uncover the complexities and detailed mechanisms of THMs in alleviating RA.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Cell Biology

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

Linli Zheng et al.

Summary: Osteoarthritis is a degenerative joint disease characterized by low-grade inflammation and high clinical heterogeneity. Changes in chondrocyte metabolism may play a key role in cartilage degeneration and disease progression, with the shift between oxidative phosphorylation and glycolysis being regulated by AMP activated protein kinase and mechanistic target of rapamycin pathways. Understanding chondrocyte metabolism and altered metabolic pathways can provide insights into age-related OA pathophysiology and guide the development of new therapeutic targets.

AGEING RESEARCH REVIEWS (2021)

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Review Medicine, General & Internal

Diagnosis and Treatment of Hip and Knee Osteoarthritis A Review

Jeffrey N. Katz et al.

Summary: Osteoarthritis is a prevalent joint disease that can impact various joints, with risk factors including age, gender, obesity, genetics, and major joint injury. Treatment typically involves exercise, weight management, education, and medication therapy. Advanced cases may require surgical intervention for pain relief and improved function.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Plant Sciences

Morroniside attenuates apoptosis and pyroptosis of chondrocytes and ameliorates osteoarthritic development by inhibiting NF-κB signaling

Huan Yu et al.

Summary: The study demonstrated that morroniside can attenuate the progression of osteoarthritis in mice by promoting cartilage matrix synthesis, inhibiting chondrocyte pyroptosis, reducing osteophyte formation, and subchondral sclerosis.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Cell Biology

Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation In Vitro and Ameliorates Osteoarthritis In Vivo

Zhen Lin et al.

Summary: In this study, it was found that Echinacoside (ECH) can suppress ER stress and ECM degradation, prevent and treat osteoarthritis (OA) effectively by upregulating Sirt1. Both in vivo and in vitro experiments demonstrated the positive effects of ECH on chondrocytes in preventing OA.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Rheumatology

The gut-joint axis in rheumatoid arthritis

Mario M. Zaiss et al.

Summary: The review discusses the role of intestinal dysbiosis in rheumatoid arthritis and highlights the potential pathogenic role of gut-derived immune cells in the joints. It also explores the hypothesis that alterations in the microbial flora may precede the onset of RA and suggests that modulation of intestinal microbiota could be a potential therapeutic approach for preventing or treating RA.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Article Medicine, Research & Experimental

Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol

Shubha Singhal et al.

Summary: The study results suggest that bioavailable turmeric extract is as effective as paracetamol in reducing pain and other symptoms of knee osteoarthritis, while also being safer and more effective in reducing CRP and TNF-alpha levels.

TRIALS (2021)

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Article Medicine, Research & Experimental

Quercetin suppresses apoptosis of chondrocytes induced by IL-1β via inactivation of p38 MAPK signaling pathway

Xiang-Peng Wang et al.

Summary: The study found that quercetin can decrease inflammatory factors in osteoarthritis patients by inhibiting the p38 pathway, suppress the expression of p38, matrix metalloprotease 13, and ADAMTS in the pathway, and enhance the expression of collagen II, thereby promoting the repair of degenerative chondrocytes and protecting articular chondrocytes.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Review Rheumatology

Efficacy and Safety of Turmeric Extracts for the Treatment of Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomised Controlled Trials

Zhiqiang Wang et al.

Summary: Turmeric extract is a safe and effective option for managing knee osteoarthritis symptoms, with significant improvement in pain and physical function compared to placebo, similar efficacy to NSAIDs, and fewer adverse events. However, current evidence from short-term studies is heterogeneous, with moderate risk of bias, leading to some uncertainty about the true effect.

CURRENT RHEUMATOLOGY REPORTS (2021)

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Article Rheumatology

Prevalence, Deaths, and Disability-Adjusted Life Years Due to Musculoskeletal Disorders for 195 Countries and Territories 1990-2017

Saeid Safiri et al.

Summary: There is a global burden of musculoskeletal disorders with increasing prevalence, deaths, and DALYs. In 2017, the global prevalence of cases approached 1.3 billion, with death and DALY rates of 121.3 thousand and 138.7 million, respectively. The prevalence of musculoskeletal disorders is higher in women and increases with age.

ARTHRITIS & RHEUMATOLOGY (2021)

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Article Integrative & Complementary Medicine

An alcohol extract prepared from the male flower of Eucommia ulmoides Oliv. promotes synoviocyte apoptosis and ameliorates bone destruction in rheumatoid arthritis

Yan Zhang et al.

Summary: The study demonstrated that Eucommia ulmoides Oliv. (EF) has potential therapeutic effects on rheumatoid arthritis by inhibiting synoviocyte proliferation and promoting apoptosis through the NF-kappa B pathway, as well as delaying bone destruction.

CHINESE MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Acupoint nanocomposite hydrogel for simulation of acupuncture and targeted delivery of triptolide against rheumatoid arthritis

Shujing Ren et al.

Summary: The study developed a novel acupoint nanocomposite hydrogel for targeted delivery of anti-inflammatory drugs, which enhanced analgesic effects and reduced systemic toxicity, showing potential therapeutic effects for rheumatoid arthritis.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Immunology

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

Damien Bertheloot et al.

Summary: Cell death is a fundamental physiological process in all living organisms, playing important roles in embryonic development, organ maintenance, aging, immune responses, and autoimmunity. Recent research has significantly increased our understanding of the mechanisms orchestrating different types of programmed cell death and how they affect the balance of cell fates. Various modalities of cell death, such as apoptosis, necroptosis, and pyroptosis, have been studied to highlight both common and unique pathways and their impact on the surrounding cells and the organism as a whole.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

Yi Shen Juan Bi Pill Regulates the Bone Immune Microenvironment via the JAK2/STAT3 Signaling Pathway in Vitro

Ya Xia et al.

Summary: The study found that YSJB can regulate the bone resorption mediated by OCs and bone immunity mediated by Tregs through the JAK2/STAT3 signaling pathway, offering a new strategy for managing the bone immune microenvironment in RA with traditional Chinese medicine.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Herbal Formula Longteng Decoction Promotes the Regression of Synovial Inflammation in Collagen-Induced Arthritis Mice by Regulating Type 2 Innate Lymphocytes

Huijie Zhang et al.

Summary: Research has shown that the Chinese herbal formula Longteng Decoction (LTD) can inhibit joint inflammation, reduce joint pain and swelling, shorten morning stiffness, decrease ESR, and suppress joint inflammation in the treatment of rheumatoid arthritis (RA). Furthermore, LTD can modulate the ILC2s immune response network to slow down the inflammatory process of synovial tissue, making it a potential adjunct or alternative therapy for RA.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation

Chenyang Zhuang et al.

Summary: The study demonstrates that Jtg inhibits osteoclast differentiation in subchondral bone and chondrocyte apoptosis in cartilage through the NF-κB signaling pathway, indicating its potential therapeutic value for treating OA. In vivo evaluation shows that Jtg significantly attenuates subchondral bone remodeling and cartilage destruction in ACLT mouse models.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Immunology

Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF-α-induced MH7A cells via inhibition of NF-κB, Akt and JNK signaling pathways

Li Yang et al.

Summary: The study found that phenylpropanoids from the root extract of Dendropanax dentiger have potential anti-rheumatoid arthritis effects, with compounds like pinoresinol and dendrocoumarin A showing significant inhibitory effects on NO production and modulation of cytokines and signaling pathways to reduce inflammation.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

Astragaloside regulates lncRNA LOC100912373 and the miR-17-5p/PDK1 axis to inhibit the proliferation of fibroblast-like synoviocytes in rats with rheumatoid arthritis

Hui Jiang et al.

Summary: The study demonstrates that astragaloside inhibits fibroblast-like synoviocytes proliferation by regulating the expression of lncRNA LOC100912373 and the miR-17-5p/PDK1 axis.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Review Cell Biology

Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Milena Iwaszko et al.

Summary: IL-4 and IL-13 are key mediators of allergic inflammation and have been implicated in the development of autoimmune diseases. Recent studies suggest that they may play a significant role in downregulating inflammatory processes underlying rheumatoid arthritis pathogenesis.

CELLS (2021)

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Article Cell Biology

Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation

Bin Li et al.

Summary: The study found that Baicalein can ameliorate subchondral bone remodeling through regulating different cell types such as osteoblasts, endothelial cells, and synovial cells. Baicalein might be an effective medicine for treating OA by potentially targeting multiple pathways.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Biotechnology & Applied Microbiology

Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering

James A. Smith et al.

Summary: Electrospinning technology produces fibers at micro- to nanometer scale, while AM technology offers geometrical freedom to build complex components quickly. Combining these two technologies can result in scaffolds that better match the natural architecture of human tissues.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Integrative & Complementary Medicine

Soufeng sanjie formula alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation

Di Hua et al.

Summary: This study demonstrates that the Soufeng sanjie formula (SF) has anti-arthritic effects by reducing arthritis symptoms, inflammation levels, and restoring Th17/Treg cell balance in collagen-induced arthritis (CIA) mice.

CHINESE MEDICINE (2021)

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Review Pharmacology & Pharmacy

Microneedle-Mediated Vaccination: Innovation and Translation

Tao Sheng et al.

Summary: The application of microneedles for vaccine delivery has gained widespread interests due to its high compliance, minimal invasiveness, and convenience. Recent advances in the development and application of microneedles for vaccination based on different delivery strategies have been introduced. The prospects for its application including opportunities and challenges are further discussed.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis

Liuting Zeng et al.

Summary: The study indicates that Curcuma longa extract and curcumin are effective and safe supplements for osteoarthritis patients, showing similar effects compared to placebo and NSAIDs. It is recommended for osteoarthritis patients to use Curcuma longa extract and curcumin supplements for an extended period.

BIOSCIENCE REPORTS (2021)

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Review Chemistry, Medicinal

Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials

Wenli Dai et al.

Summary: The analysis of 10 RCTs shows that Curcuma longa extract is significantly associated with pain relief and functional improvement in knee OA patients, exceeding the minimum clinical importance differences. More high-quality RCTs with large sample sizes are needed to further confirm the benefits of Curcuma longa extract on knee OA.

PHYTOTHERAPY RESEARCH (2021)

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Article Pharmacology & Pharmacy

ZhiJingSan Inhibits Osteoclastogenesis via Regulating RANKL/NF-kappa B Signaling Pathway and Ameliorates Bone Erosion in Collagen-Induced Mouse Arthritis

Yuanyuan Ling et al.

Summary: The study found that ZhiJingSan delayed the onset of arthritis, alleviated joint inflammation, and reduced bone erosion in CIA mice. Additionally, ZJS decreased serum levels of TNF-alpha, IL-6, and reduced the number of osteoclasts, as well as the expression of MMP9 and cathepsin K in the ankle joints of CIA mice.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Anti-Rheumatoid Arthritic Effects of Paris Saponin VII in Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Adjuvant-Induced Arthritis in Rats

Mei Meng et al.

Summary: PS VII inhibits the proliferation and induces apoptosis of RA-FLS and MH7A cells by regulating the mitochondrial apoptotic pathway and the JNK and p38 MAPK pathways.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Oncology

Inhibition of MAGL activates the Keap1/Nrf2 pathway to attenuate glucocorticoid-induced osteonecrosis of the femoral head

Ning Yang et al.

Summary: Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) remains poorly understood, with studies suggesting that monoacylglycerol lipase (MAGL) in the endocannabinoid system plays a crucial role in regulating oxidative stress and BMSC fate. Inhibition of MAGL can reduce oxidative stress, rescue BMSC apoptosis, and effectively attenuate GC-induced ONFH through the Keap1/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Therefore, MAGL may be a promising target for prevention and treatment of GC-induced ONFH.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Integrative & Complementary Medicine

Myrtenal and β-caryophyllene oxide screened from Liquidambaris Fructus suppress NLRP3 inflammasome components in rheumatoid arthritis

Wen-Xuan Li et al.

Summary: In this study, it was found that the petroleum ether extract of Liquidambaris Fructus (LF) showed superior efficacy in alleviating symptoms of adjuvant-induced arthritis (AIA) in rats compared to other extracts. The active ingredients myrtenal and beta-caryophyllene oxide in PEL were identified to inhibit the activation of NLRP3 inflammasome, suggesting their potential therapeutic effects in rheumatoid arthritis (RA).

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

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Article Health Care Sciences & Services

Comparative efficacy and safety of four classical prescriptions for clearing damp-heat recommended by clinical guidelines in treating rheumatoid arthritis: a network meta-analysis

Shaowei Li et al.

Summary: In China, herbal formulae for clearing damp-heat are widely used in treating rheumatoid arthritis (RA) along with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). This study aimed to summarize and compare the clinical effects of 4 guideline-recommended formulae. The results showed that Simiao pill + csDMARD was superior in clinical efficiency, reducing C-reactive protein and erythrocyte sedimentation rate levels. Fewer adverse events were reported with this combination therapy.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling

Yanghua Tang et al.

Summary: The study found that icariin can alleviate osteoarthritis by regulating the autophagy of chondrocytes via mediating the PI3K/AKT/mTOR signaling pathway.

BIOENGINEERED (2021)

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Article Plant Sciences

Wutou decoction attenuates rheumatoid arthritis by modulating the Ahr/LOC101928120/SHC1 pathway

Dan Wu et al.

Summary: This study reveals a new mechanism by which Wutou decoction alleviates rheumatoid arthritis by modulating the Ahr/LOC101928120/SHC1 pathway. Wutou decoction can reduce joint swelling, suppress chondrocyte apoptosis, and decrease the production of reactive oxygen species.

PHARMACEUTICAL BIOLOGY (2021)

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Article Integrative & Complementary Medicine

Network analysis indicating the pharmacological mechanism of Yunpi-Qufeng-Chushi-prescription in prophylactic treatment of rheumatoid arthritis

Lin Li et al.

Summary: The study showed that by targeting hub genes such as C3, EGFR, SRC, and MMP9, YQCP can impact B cell maturation, inhibit B cell-related IgG production, regulate oxidative stress, and modulate the activity of enzymes like peroxidase and metallopeptidase. This could potentially delay the onset and progression of RA, benefiting pre-RA and early RA patients.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

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Article Biochemistry & Molecular Biology

Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice

Ximiao Chen et al.

Summary: The study found that Puerarin may potentially alleviate the progression of osteoarthritis by inhibiting inflammatory mediators and apoptosis, as well as slowing down ECM degradation in chondrocytes. The mechanism may be related to the regulation of the Nrf2/HO-1 pathway.

FOOD & FUNCTION (2021)

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Review Rheumatology

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

Wenhui Hu et al.

Summary: This article discusses the changes in subchondral bone during OA progression and potential strategies for treating OA, including restoring abnormal remodeling and blocking blood vessels, highlighting the relationship between the subchondral bone microenvironment and OA pain.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Article Cell & Tissue Engineering

Chondrogenesis mediates progression of ankylosing spondylitis through heterotopic ossification

Tao Yu et al.

Summary: Inflammatory microenvironment in AS promotes chondrogenesis in spine ligaments. Giant osteoclasts in ligament inflammation and calcified cartilage induce new bone formation through TGF-beta activity. Uncoupled osteoclast resorption and bone formation contribute to the progression of ossification in AS.

BONE RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Pyroptosis: mechanisms and diseases

Pian Yu et al.

Summary: Pyroptosis has gained attention for its association with innate immunity and diseases. The discovery of the gasdermin family has expanded the research scope of pyroptosis, revealing its potential effects on tumor development. Pyroptosis serves as a double-edged sword in tumors, with the rational utilization of its dual effect providing insights for new drug development and understanding tumor formation and progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Plant Sciences

Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis

Shu-jun Wei et al.

Summary: Guizhi-Shaoyao-Zhimu decoction has shown anti-rheumatoid arthritis effects in CII-induced arthritis rats, suggesting its potential use as a supplement and alternative drug therapy for RA.

PHARMACEUTICAL BIOLOGY (2021)

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Article Rheumatology

Polysaccharide from Angelica sinensis attenuates SNP-induced apoptosis in osteoarthritis chondrocytes by inducing autophagy via the ERK1/2 pathway

Chao Xu et al.

Summary: This study demonstrated that Angelica sinensis polysaccharide (ASP) significantly alleviated SNP-induced chondrocyte apoptosis by activating ERK1/2-dependent autophagy, indicating ASP as a potential therapeutic supplement for osteoarthritis treatment.

ARTHRITIS RESEARCH & THERAPY (2021)

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Article Engineering, Biomedical

Development of epimedin A complex drugs for treating the osteoporosis

Ying Liu et al.

Summary: Osteoporosis is a common disease involving bone degeneration that is expected to increase with aging population. Current treatment methods are not ideal, leading to the development of a novel drug system that has shown promising results in promoting bone regeneration.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2021)

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Article Immunology

Scutellarin ameliorates cartilage degeneration in osteoarthritis by inhibiting the Wnt/β-catenin and MAPK signaling pathways

Fuen Liu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Plant Sciences

Zishen Tongluo formula ameliorates collagen-induced arthritis in mice by modulation of Th17/Treg balance

Pei Yang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Rheumatology

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update

Josef S. Smolen et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Article Biochemistry & Molecular Biology

Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis

Shasha Luo et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

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Article Integrative & Complementary Medicine

Effects of hydroalcoholic extract of Berberis Integerrima on the anthropometric indices and metabolic profile in active rheumatoid arthritis patients

Naheed Aryaeian et al.

COMPLEMENTARY THERAPIES IN MEDICINE (2020)

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Article Pharmacology & Pharmacy

Leocarpinolide B attenuates LPS-induced inflammation on RAW264.7 macrophages by mediating NF-κB and Nrf2 pathways

Ke-Gang Linghu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Plant Sciences

Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes

Jiaming Hu et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Medicine, General & Internal

Osteoarthritis Pathology, Diagnosis, and Treatment Options

Benjamin Abramoff et al.

MEDICAL CLINICS OF NORTH AMERICA (2020)

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Article Plant Sciences

Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes

Shou-Di He et al.

PHARMACEUTICAL BIOLOGY (2020)

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Article Plant Sciences

Er Miao San, a traditional Chinese herbal formula, attenuates complete Freund's adjuvant-induced arthritis in rats by regulating Th17/Treg cells

Xing Dai et al.

PHARMACEUTICAL BIOLOGY (2020)

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Article Pharmacology & Pharmacy

Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression

Chenchen Shi et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Rheumatology

2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

Sharon L. Kolasinski et al.

ARTHRITIS CARE & RESEARCH (2020)

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Article Rheumatology

Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017

Ziyi Jin et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Review Biotechnology & Applied Microbiology

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

Mohammad Tobeiha et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Review Biochemistry & Molecular Biology

The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression

Yeri Alice Rim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Medicinal

Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-kappa B and p38/MAPK Pathways

Shuang Feng et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

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Article Pharmacology & Pharmacy

Synergistic Effects of Erzhi Pill Combined With Methotrexate on Osteoblasts Mediated via the Wnt1/LRP5/β-Catenin Signaling Pathway in Collagen-Induced Arthritis Rats

Xiaoya Li et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Chemistry, Medicinal

Herbal formulation turmeric extract, black pepper, and ginger versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial

Motahar Heidari-Beni et al.

PHYTOTHERAPY RESEARCH (2020)

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Article Orthopedics

3D-Printed Extracellular Matrix/Polyethylene Glycol Diacrylate Hydrogel Incorporating the Anti-inflammatory Phytomolecule Honokiol for Regeneration of Osteochondral Defects

Shouan Zhu et al.

AMERICAN JOURNAL OF SPORTS MEDICINE (2020)

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Review Integrative & Complementary Medicine

Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine

Xu-zhao Li et al.

CHINESE MEDICINE (2020)

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Article Pharmacology & Pharmacy

Cinnamic Aldehyde Inhibits Lipopolysaccharide-Induced Chondrocyte Inflammation and Reduces Cartilage Degeneration by Blocking the Nuclear Factor-Kappa B Signaling Pathway

Pu Chen et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Integrative & Complementary Medicine

Effect of sweet fennel seed extract capsule on knee pain in women with knee osteoarthritis

Marzieh Alazadeh et al.

COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE (2020)

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Article

Apoptosis (programmed cell death) and its signals - A review

E. Obeng

BRAZILIAN JOURNAL OF BIOLOGY (2020)

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Article Chemistry, Medicinal

Chrysin Attenuates the NLRP3 Inflammasome Cascade to Reduce Synovitis and Pain in KOA Rats

Taiyang Liao et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

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Article Cell Biology

Cinnamaldehyde Attenuates the Progression of Rheumatoid Arthritis through Down-Regulation of PI3K/AKT Signaling Pathway

Xiang Li et al.

INFLAMMATION (2020)

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Article Genetics & Heredity

Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis

Yan Zhou et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2020)

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Article Biochemistry & Molecular Biology

Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities

Kai Yuan et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2020)

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Review Medicine, General & Internal

Autophagy in Human Diseases

Noboru Mizushima et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Pharmacology & Pharmacy

Sigesbeckia orientalisL. Extract Alleviated the Collagen Type II-Induced Arthritis Through Inhibiting Multi-Target-Mediated Synovial Hyperplasia and Inflammation

Ke-Gang Linghu et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis

Yingjie Shi et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis

Bo Hu et al.

AMB EXPRESS (2020)

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Article Immunology

Leonurine Regulates Treg/Th17 Balance to Attenuate Rheumatoid Arthritis Through Inhibition of TAZ Expression

Yan-Yi Du et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Cell Biology

Osteoblast-Osteoclast Communication and Bone Homeostasis

Jung-Min Kim et al.

CELLS (2020)

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Article Oncology

Micheliolide alleviates ankylosing spondylitis (AS) by suppressing the activation of the NLRP3 inflammasome and maintaining the balance of Th1/Th2 via regulating the NF-κB signaling pathway

Zhong-Gu Tian et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Review Cell Biology

The Role of Autophagy in Osteoarthritis

Ran Duan et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Immunomodulation of MSCs and MSC-Derived Extracellular Vesicles in Osteoarthritis

Xige Zhao et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Plant Sciences

Safflower yellow alleviates osteoarthritis and prevents inflammation by inhibiting PGE2 release and regulating NF-κB/SIRT1/AMPK signaling pathways

Chunli Wang et al.

PHYTOMEDICINE (2020)

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Article Plant Sciences

Anti-proliferation and anti-migration effects of an aqueous extract ofCinnamomi ramuluson MH7A rheumatoid arthritis-derived fibroblast-like synoviocytes through induction of apoptosis, cell arrest and suppression of matrix metalloproteinase

Jia Liu et al.

PHARMACEUTICAL BIOLOGY (2020)

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Review Rheumatology

Innate lymphoid cells in inflammatory arthritis

Weiting Fang et al.

ARTHRITIS RESEARCH & THERAPY (2020)

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Review Pharmacology & Pharmacy

Chondrocyte dedifferentiation and osteoarthritis (OA)

Edith Charlier et al.

BIOCHEMICAL PHARMACOLOGY (2019)

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Article Engineering, Biomedical

Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant

Liping Tong et al.

BIOMATERIALS (2019)

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Article Biochemistry & Molecular Biology

Therapeutic effects of polysaccharides from Anoectochilus roxburghii on type II collagen-induced arthritis in rats

Yaoli Guo et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Agriculture, Multidisciplinary

Liquiritin from Glycyrrhiza uralensis Attenuating Rheumatoid Arthritis via Reducing Inflammation, Suppressing Angiogenesis, and Inhibiting MAPK Signaling Pathway

Ke-feng Zhai et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

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Article Plant Sciences

Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis

Caiwei Wang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Article Pharmacology & Pharmacy

Apoptotic effect of Aralia echinocaulis extract on fibroblast-like synoviocytes in rats with adjuvant-induced arthritis via inhibiting the Akt/Hif-1α signaling pathway in vitro

Yunzhi Li et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Neutrophils in Rheumatoid Arthritis: Breaking Immune Tolerance and Fueling Disease

Liam J. O'Neil et al.

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