期刊
AGEING RESEARCH REVIEWS
卷 88, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2023.101952
关键词
Amyloid; Alzheimer disease; White matter hyperintensities; Dementia
This systematic review and meta-analysis investigated the relationship between amyloid burden and white matter hyperintensities (WMH) in older adults without cognitive impairment. The findings revealed an association between amyloid pathology and WMH in cerebrospinal fluid (CSF) and positron emission tomography (PET), but the relationship in plasma remains unclear. Further studies should explore the relationship between plasma amyloid-beta and WMH to identify at-risk individuals in preclinical stages.
Alzheimer's disease (AD) is the most common cause of dementia, characterized by the aggregation of amyloid-beta (A beta) proteins into plaques. Individuals with AD frequently show mixed pathologies, often caused by cerebral small vessel disease (CSVD), resulting in lesions such as white matter hyperintensities (WMH). The current systematic review and meta-analysis investigated the cross-sectional relationship between amyloid burden and WMH in older adults without objective cognitive impairment. A systematic search performed in PubMed, Embase, and PsycINFO yielded 13 eligible studies. A beta was assessed using PET, CSF, or plasma measurements. Two meta-analyses were performed: one on Cohen's d metrics and one on correlation coefficients. The meta-analyses revealed an overall weighted small-to-medium Cohen's d of 0.55 (95% CI: 0.31-0.78) in CSF, an overall correlation of 0.31 (0.09-0.50) in CSF, and a large Cohen's d of 0.96 (95% CI: 0.66-1.27) in PET. Only two studies assessed this relationship in plasma, with an effect size of -0.20 (95% CI:-0.75 to 0.34). These findings indicate a relationship between both amyloid and vascular pathologies in cognitively normal adults in PET and CSF. Future studies should assess the possible relationship of blood amyloid-beta and WMH for broader identification of at risk individuals showing mixed pathology in preclinical stages.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据