Cu(II)-Catalyzed [3+2]-Annulation of 2-Pyridinyl-substituted p-Quinone Methides with Enaminones: Access to Functionalized Indolizine Derivatives

This article describes an effective and atom-economical protocol to access a wide range of synthetically important functionalized indolizine derivatives. This transformation basically takes place through a Cu(II) catalyzed formal [3+2] annulation of 2-pyridinyl substituted p-quinone methides with enaminones. This method displayed a good functional group tolerance and, was found to be effective for most of the enaminones and p-QMs, and the corresponding indolizines were obtained in moderate to good yields.

Automated summary

This article describes an effective and economical method for synthesizing various important functionalized indolizine derivatives. This transformation is achieved through a Cu(II)-catalyzed [3+2] annulation of 2-pyridinyl substituted p-quinone methides with enaminones. The method has good functional group tolerance and is effective for most enaminones and p-QMs, resulting in moderate to good yields of indolizines.