期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202300528
关键词
Palladium; C-H activation; alkenylation; heterocyclic aldehydes; mechanochromism
The palladium (II) catalyzed direct C3-(sp(2))-H alkenylation of five membered heterocyclic aldehydes has been developed using 3-aminobutanoic acid as a catalytic transient directing group. This method allows for highly site-selective C3-alkenylation of heterocyclic aldehydes with various acrylates, featuring exclusive E-selectivity and a broad substrate scope. Additionally, this protocol has proven to be useful in the construction of mechanochromic luminogens.
The palladium (II) catalyzed direct C3-(sp(2))-H alkenylation of five membered heterocyclic aldehydes has been developed using 3-aminobutanoic acid as a catalytic transient directing group. A wide range of heterocyclic aldehydes reacted with various acrylates to afford highly site-selective C3-alkenylated products. This method features an exclusive E-selective alkenylation at the C3-position of heterocyclic aldehydes with a broad substrate scope. The protocol also proved to be useful to construct the mechanochromic luminogen.
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