Visible-Light-Mediated Amide Synthesis in Deep Eutectic Solvents

In the present study, for the first time environmentally friendly deep eutectic solvents (DESs) are used as reaction media to perform an efficient, simple and straightforward photocatalytic amide synthesis at room temperature using thioacids and amines. This method features mild conditions, a broad substrate scope, high yields (& LE;99%) under ambient conditions with air and moisture tolerance. Moreover, the applied operationally mild reaction conditions tolerate the presence of several different functional group substituents on the amine counterpart. Finally, the developed approach allows the recycling of the reaction medium and catalyst for at least three consecutive cycles without a significant decrease in the reaction yield.

Automated summary

In this study, environmentally friendly deep eutectic solvents (DESs) were used for the first time as reaction media for efficient photocatalytic amide synthesis at room temperature. The method showed mild conditions, a broad substrate scope, high yields (& LE;99%), and tolerance to air and moisture. It also allowed for the recycling of the reaction medium and catalyst without significant decrease in yield for at least three consecutive cycles.