☆ 4.8 Article

Tumor Microenvironment-Responsive Nanoparticles Amplifying STING Signaling Pathway for Cancer Immunotherapy

ADVANCED MATERIALS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Multidisciplinary Sciences

STING as an emerging therapeutic target for drug discovery: Perspectives from the global patent landscape

Xiangjun Kong et al.

Summary: This article aims to summarize the current situation, development trends, and emerging technologies in the field of STING modulation. Through the analysis of clinical-stage drugs and global patent status, it is found that research and development on STING are increasing, but the current STING agonists have shown limited anti-tumor efficacy in clinical trials.

JOURNAL OF ADVANCED RESEARCH (2023)

添加到收藏夹

Article Nanoscience & Nanotechnology

A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion

Seung Mo Jin et al.

Summary: In this study, a kinetically activating nanoadjuvant (K-nanoadjuvant) is proposed to integrate two waves of innate immune stimuli, resulting in effective antitumour immunity without immune cell exhaustion. The combinatorial code of K-nanoadjuvant is optimized in terms of the order, duration, and time window between activating Toll-like receptor 7/8 agonist and other Toll-like receptor agonists. K-nanoadjuvant induces effector/non-exhausted dendritic cells, CD8(+) T cells, and natural killer cells, leading to strong antitumour immunity with minimal toxicity when used as a monotherapy or in combination therapy with other treatments.

NATURE NANOTECHNOLOGY (2023)

添加到收藏夹

Review Chemistry, Multidisciplinary

Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Shuang Liang et al.

Summary: Immunotherapy has made significant progress in cancer therapy, but it still faces challenges such as low response rates and immune-related adverse events. Sonodynamic therapy (SDT) has gained attention for treating deep-seated tumors and can trigger systemic anti-tumor immune response through immunogenic cell death. Nanotechnology has revolutionized SDT, leading to the development of innovative nanosonosensitizers and synergistic treatment modalities. This review summarizes the recent advances in cancer sonodynamic immunotherapy and explores how nanotechnology can enhance the anti-tumor immune response.

ADVANCED MATERIALS (2023)

添加到收藏夹

Review Chemistry, Multidisciplinary

Manganese-Based Tumor Immunotherapy

Ke Zhang et al.

Summary: As an essential micronutrient, manganese (Mn) plays important roles in various physiological processes and has versatile applications in tumor immunotherapy. Mn-based nanoparticles can be used as biocompatible nanocarriers, adjuvants to regulate tumor immune microenvironment, activators of host's immune system, and contrast agents for monitoring tumor immunotherapy via MRI. This comprehensive review focuses on the recent progress, biomedical applications, challenges, and future developments of Mn-based nanoplatforms in tumor immunotherapy.

ADVANCED MATERIALS (2023)

添加到收藏夹

Article Pharmacology & Pharmacy

Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell- mediated cytotoxicity mediating PD-L1highCD11bD cells elimination in hepatocellular carcinoma

Jizhou Tan et al.

Summary: Cryoablation and microwave ablation are two main local treatments for hepatocellular carcinoma. This study found that cryoablation induced higher tumoral PD-L1 expression and more T cell infiltration, but less infiltration of PD-L1highCD11b+ myeloid cells compared to microwave ablation in hepatocellular carcinoma. Furthermore, cryoablation showed better curative effect when combined with anti-PD-L1 antibody in mouse models.

ACTA PHARMACEUTICA SINICA B (2023)

添加到收藏夹

Article Cell Biology

NF-KB activation enhances STING signaling by altering microtubule-mediated STING trafficking

Lulu Zhang et al.

Summary: NF-KB pathway activation enhances STING signaling by regulating microtubule-mediated STING trafficking, leading to robust host antiviral defense and amplified interferon response.

CELL REPORTS (2023)

添加到收藏夹

Article Chemistry, Multidisciplinary

Acid-Ionizable Iron Nanoadjuvant Augments STING Activation for Personalized Vaccination Immunotherapy of Cancer

Fangmin Chen et al.

Summary: This study discovered that iron oxide nanoparticles (IONPs) can significantly enhance the production of type-I interferon (IFN-I) and achieve a dosage-sparing effect when combined with the STING agonist MSA-2. Acid-ionizable copolymers are coassembled with IONPs and MSA-2 to concentrate STING activation in lymph nodes and improve antigen cross-presentation. The iron nanoadjuvant PEIM effectively delivers antigens to antigen-presenting cells (APCs) and induces a potent and durable antitumor immune response.

ADVANCED MATERIALS (2023)

添加到收藏夹

Article Immunology

Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

Ellen Duong et al.

Summary: In this study, the researchers investigated the different roles of tumor-infiltrating dendritic cells (DCs) in anti-tumor immunity. By comparing spontaneously regressing and progressing tumors, they found that tumor-reactive CD8+ T cells were lost in progressing tumors but preserved in regressing tumors. They also identified a specific type of DCs (ISG(+) DCs) in regressing tumors that activated CD8+ T cells and played an important role in presenting tumor-derived antigens. Furthermore, they showed that exogenous IFN-b stimulation could restore the lost anti-tumor immunity in progressing tumors. These findings suggest that targeting this functional DC state may be a potential approach for the treatment of human diseases.

IMMUNITY (2022)

添加到收藏夹

Review Oncology

Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways

Lukas Kraehenbuehl et al.

Summary: The discovery and clinical implementation of immune-checkpoint inhibitors like CTLA4, PD-1, and PD-L1 have significantly improved outcomes for patients with advanced-stage cancers. However, a majority of patients do not respond to these agents, emphasizing the need for further research into alternative immunomodulatory pathways and targeting tumor metabolism to enhance treatment efficacy.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis

Rongqing Pan et al.

Summary: The mitochondrial apoptosis pathway is crucial for efficient NK cell killing, with pre-activated NK cells demonstrating resistance to BH3 mimetics. Combining BH3 mimetics with NK cells synergistically kills cancer cells and inhibits tumor growth in vivo.

CELL (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

A pH-/Enzyme-Responsive Nanoparticle Selectively Targets Endosomal Toll-like Receptors to Potentiate Robust Cancer Vaccination

Heming Xia et al.

Summary: This study reports a pH-/enzyme-responsive TLR7/8 agonist-conjugated nanovaccine (TNV) that intelligently responds to the endosomal environment and releases the TLR7/8 agonist precisely at the receptor site, resulting in effective immune activation.

NANO LETTERS (2022)

添加到收藏夹

Article Chemistry, Physical

STING and TLR7/8 agonists-based nanovaccines for synergistic antitumor immune activation

Bo-Dou Zhang et al.

Summary: Immunostimulatory therapies based on pattern recognition receptors have shown effectiveness in fighting against cancer. However, their efficacy is limited. By using a combination of multiple agonist molecules, researchers have developed multicomponent nanovaccines that trigger strong T-cell responses and significantly inhibit tumor growth.

NANO RESEARCH (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bioinspired magnetic nanocomplexes amplifying STING activation of tumor-associated macrophages to potentiate cancer immunotherapy

Tianliang Li et al.

Summary: This study developed bioinspired magnetic nanocomplexes to enhance antitumor immunogenicity by amplifying the STING-regulated immune cascade of TAMs. The nanocomplexes specifically accumulated at the tumor site and repolarized TAMs into antitumor M1 phenotype, leading to activation of the STING pathway and priming of tumor-specific CTLs. In combination with immune checkpoint blockade therapy, the nanocomplexes effectively inhibited tumor growth and prolonged survival in mouse models, providing new insights for cancer immunotherapy.

NANO TODAY (2022)

添加到收藏夹

Article Nanoscience & Nanotechnology

Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles

Xuefeng Li et al.

Summary: Researchers have developed a novel ultrasound-guided cancer immunotherapy platform that activates the immune response and enhances cancer treatment by targeting the STING pathway in APCs. This study provides a new strategy for targeted immunotherapy.

NATURE NANOTECHNOLOGY (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development

Deying Yang et al.

Summary: This study presents a new strategy for self-adjuvanting vaccine development using different types of covalently-linked immunostimulants as the carrier molecule. A three-component vaccine (MPLA-Tn-KRN7000) containing the TLR4 ligand MPLA and the iNKT cell agonist KRN7000 was designed and synthesized, expanding the field of fully synthetic self-adjuvanting vaccines. The immunological evaluation showed that MPLA-Tn-KRN7000 induced robust Tn-specific and T cell-dependent immunity.

ACTA PHARMACEUTICA SINICA B (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants

Na Fan et al.

Summary: In this study, a novel mRNA delivery system was developed by introducing a STING agonist, manganese, to promote antigen-presenting cell maturation and mRNA expression. mRNA vaccines targeting the Delta and Omicron variants were prepared and both induced specific immune responses with strong neutralization ability and good safety.

SCIENCE ADVANCES (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Spatio-temporal delivery of both intra- and extracellular toll-like receptor agonists for enhancing antigen-specific immune responses

Nannan Wang et al.

Summary: Researchers successfully delivered antigens and TLR agonists to the surface and interior of dendritic cells through lipid-polymer hybrid nanoparticles (LPNPs), synergistically activating dendritic cells and enhancing immune responses. The LPNPs-based nanovaccines showed good biocompatibility, promoted antigen uptake, enhanced dendritic cell maturation and cytokine production, and effectively suppressed tumor growth.

ACTA PHARMACEUTICA SINICA B (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Manganese Coordination Micelles That Activate Stimulator of Interferon Genes and Capture In Situ Tumor Antigens for Cancer Metalloimmunotherapy

Jiexin Li et al.

Summary: This study developed a metal micellar nanovaccine that elevates interferon-beta levels by the synergy between Mn and ABZI, resulting in sufficient DC maturation and tumor cell death. Additionally, the use of ONc in laser treatment induces immunogenic cell death and enhances immune responses. Experimental results showed that this nanovaccine achieved strong anticancer efficacy in mouse tumor models.

ACS NANO (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Activating Innate Immunity by a STING Signal Amplifier for Local and Systemic Immunotherapy

Wen Song et al.

Summary: In this study, M@P@HA nanoparticles were used as a STING signal amplifier to enhance innate immunotherapy in tumors. The nanoparticles released reactive oxygen species under light irradiation, disrupting cellular redox homeostasis and initiating the STING signal through damaged mitochondrial dsDNA. The immunoregulator Mn2+ increased the activity of cGAS and STING, further amplifying the STING signal in tumor cells. Additionally, the STING signal of TAMs was activated by capturing dsDNA and Mn2+ that escaped from tumor cells, enhancing innate immunity.

ACS NANO (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Macrophage phenotype-switching in cancer

Jiamin Zhang et al.

Summary: TAMs play a crucial role in tumorigenesis and malignant progression, and understanding their phenotype-switching is important for tumor therapy.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

添加到收藏夹

Article Oncology

Hyperbaric oxygen facilitates teniposide-induced cGAS-STING activation to enhance the antitumor efficacy of PD-1 antibody in HCC

Kun Li et al.

Summary: The study found that the chemotherapy agent teniposide effectively activates the cGAS-STING signaling in HCC patients. Combining hyperbaric oxygen therapy can enhance the therapeutic effect of teniposide on HCC and improve the response to PD-1 immunotherapy.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Engineered Nanoprobes for Immune Activation Monitoring

Mengli Zhou et al.

Summary: Non-invasive visualization of immune activation is crucial for monitoring immune response and evaluating therapeutic outcomes. Molecular probes that can selectively turn on signals in the presence of immune biomarkers have been developed to enable non-invasive, dynamic, and real-time imaging with high sensitivity. Innovative engineered nanoprobes combined with diverse imaging modalities have shown significance for assessing immune system activation.

ACS NANO (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

Carlo Pifferi et al.

Summary: Modern subunit vaccines based on homogeneous antigens offer precise targeting and safety, but are less immunogenic and require adjuvants. Both natural and synthetic carbohydrate structures have been used as adjuvants in clinical trials, but naturally derived ones are difficult to obtain and unstable.

NATURE REVIEWS CHEMISTRY (2021)

添加到收藏夹

Review Oncology

Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes

Wantao Wu et al.

Summary: Immunotherapy has significantly improved the prognosis of many malignant tumor patients in the era of precision medicine, with deficient mismatch repair (dMMR)/microsatellite instability (MSI) status used as a biomarker to predict response. However, some patients still respond poorly, partly due to intratumor heterogeneity propelled by dMMR/MSI. Understanding the mechanisms of dMMR/MSI's impact on immunotherapy is crucial for better outcomes.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy

Xiaoqi Sun et al.

Summary: Metalloimmunotherapy utilizes metal ions to amplify the anti-tumour immune response promoted by STING agonists, forming nanoparticles that effectively deliver STING agonists and achieve remarkable therapeutic efficacy in multiple tumour models. This work highlights the great potential of coordination nanomedicine for metalloimmunotherapy.

NATURE NANOTECHNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles

Liang Jia et al.

Summary: This study presents a facile strategy to prepare cell membrane-coated nanoclusters with pH-responsiveness, which can target tumors and release drugs effectively.

NANO TODAY (2021)

添加到收藏夹

Article Immunology

Novel Potent IFN-γ-Inducing CD8+ T Cell Epitopes Conserved among Diverse Bovine Viral Diarrhea Virus Strains

Neha Sangewar et al.

Summary: This study identified highly cross-reactive BVDV-specific CD8(+) T cells in cattle and novel IFN-gamma-inducing CD8(+) T cell epitopes from different regions of BVDV polyprotein. These conserved epitopes were found to elicit broadly reactive CD8(+) T cell responses against diverse BVDV strains, suggesting their potential use in developing a more effective CD8(+) T cell-based BVDV vaccine.

JOURNAL OF IMMUNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Enhanced Antitumor Immune Responses via a Self-Assembled Carrier-Free Nanovaccine

Dan Liu et al.

Summary: Nanovaccines incorporating two adjuvants and antigens were efficiently constructed, overcoming obstacles in traditional vaccine preparation and enhancing immune responses. The selected adjuvants achieved a notable immune response through synergistic activation of signaling pathways, significantly inhibiting tumor growth and prolonging the survival time of mice.

NANO LETTERS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cooperative Self-Assembled Nanoparticle Induces Sequential Immunogenic Cell Death and Toll-Like Receptor Activation for Synergistic Chemo-immunotherapy

Yaoqi Wang et al.

Summary: The study engineered sequential pH/redox-responsive nanoparticles to activate the immune microenvironment of tumors and lymph nodes, enhancing the antitumor immune response and providing a potential candidate for synergistic cancer chemo-immunotherapy.

NANO LETTERS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine

Junhua Mai et al.

Summary: This study introduces a novel therapeutic vaccine, mu GCVax, which effectively stimulates infiltration of antigen-specific T cells into tumor tissue. It has shown inhibitory effects on various tumor models and can promote antitumor immune responses, indicating a high potential for personalized cancer therapy.

ADVANCED SCIENCE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

Francesco Marangoni et al.

Summary: The study reveals that T regulatory cells interact with tumor-associated conventional dendritic cells to receive activation signals and self-regulate their function through a CTLA-4- and CD28-dependent feedback loop. CTLA-4 blockade may lead to Treg cell hyper-proliferation and impact therapeutic benefits in cancer patients.

CELL (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Chitosan-Poly(Acrylic Acid) Nanoparticles Loaded with R848 and MnCl2 Inhibit Melanoma via Regulating Macrophage Polarization and Dendritic Cell Maturation

Xinghan Liu et al.

Summary: The study demonstrates that R-M@CS-PAA NPs can exert anti-tumor effects by promoting the infiltration of M1 macrophages and CD8(+) T cells, reducing the number of suppressive immune cells in the tumor microenvironment.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

添加到收藏夹

Review Immunology

The Effects of Trained Innate Immunity on T Cell Responses; Clinical Implications and Knowledge Gaps for Future Research

Dearbhla M. Murphy et al.

Summary: Trained immunity, also known as innate immune training, involves the medium-term epigenetic and metabolic reprogramming of innate immune cells in response to an initial challenge, resulting in altered responses to subsequent challenges. It can lead to increased production of proinflammatory mediators, affect T cell responses, and create a new immune pattern that interacts with adaptive immunity.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Oncology

STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation

Takashi Nakamura et al.

Summary: STING-LNP treatment can overcome PD-1 resistance by activating NK cells, resulting in an increase in PD-L1 expression on cancer cells and ultimately producing a synergistic antitumor effect.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

添加到收藏夹

Review Immunology

The cGAS-STING pathway as a therapeutic target in inflammatory diseases

Alexiane Decout et al.

Summary: The cGAS-STING signaling pathway plays a crucial role in inflammation in infection, cellular stress, and tissue damage settings. It has the ability to sense and regulate cellular responses to DNA and has the potential to be targeted in the treatment of various inflammatory diseases.

NATURE REVIEWS IMMUNOLOGY (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Binbin Ding et al.

ADVANCED MATERIALS (2020)

添加到收藏夹

Review Oncology

The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer

John Kwon et al.

CANCER DISCOVERY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Daniel S. Leventhal et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Cell Biology

Molecular mechanisms and cellular functions of cGAS-STING signalling

Karl-Peter Hopfner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

MnOxNanospikes as Nanoadjuvants and Immunogenic Cell Death Drugs with Enhanced Antitumor Immunity and Antimetastatic Effect

Binbin Ding et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

添加到收藏夹

Review Immunology

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Yuanyuan Zhang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

添加到收藏夹

Review Oncology

cGAS-STING, an important pathway in cancer immunotherapy

Minlin Jiang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

添加到收藏夹

Article Cell Biology

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

Mengze Lv et al.

CELL RESEARCH (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Stimulus-responsive sequential release systems for drug and gene delivery

Sepideh Ahmadi et al.

NANO TODAY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

C9orf72 in myeloid cells suppresses STING-induced inflammation

Madelyn E. McCauley et al.

NATURE (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

Nanomedicines modulating tumor immunosuppressive cells to enhance cancer immunotherapy

Yuefei Zhu et al.

ACTA PHARMACEUTICA SINICA B (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Precise delivery of obeticholic acid via nanoapproach for triggering natural killer T cell-mediated liver cancer immunotherapy

Guofeng Ji et al.

ACTA PHARMACEUTICA SINICA B (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA

Katherine C. Barnett et al.

CELL (2019)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

Lei Miao et al.

NATURE BIOTECHNOLOGY (2019)

添加到收藏夹

Review Multidisciplinary Sciences

Harnessing innate immunity in cancer therapy

Olivier Demaria et al.

NATURE (2019)

添加到收藏夹

Article Immunology

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

Chenguang Wang et al.

IMMUNITY (2018)

添加到收藏夹

Article Immunology

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity

Qing Zhang et al.

NATURE IMMUNOLOGY (2018)

添加到收藏夹

Article Oncology

Oncolytic vaccines increase the response to PD-L1 blockade in immunogenic and poorly immunogenic tumors

S. Feola et al.

ONCOIMMUNOLOGY (2018)

添加到收藏夹

Article Nanoscience & Nanotechnology

Gadolinium Metallofullerene-Polypyrrole Nanoparticles for Activatable Dual-Modal Imaging-Guided Photothermal Therapy

Sheng Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

添加到收藏夹

Article Immunology

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

Assaf Marcus et al.

IMMUNITY (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA

Rein Verbeke et al.

JOURNAL OF CONTROLLED RELEASE (2017)

添加到收藏夹

Article Nanoscience & Nanotechnology

A STING-activating nanovaccine for cancer immunotherapy

Min Luo et al.

NATURE NANOTECHNOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular basis of cooperativity in pH-triggered supramolecular self-assembly

Yang Li et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Immunology

TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN

Burcu Temizoz et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Article Cell Biology

Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth

Wenchao Zhou et al.

NATURE CELL BIOLOGY (2015)

添加到收藏夹

Article Immunology

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Liufu Deng et al.

IMMUNITY (2014)

添加到收藏夹

Article Oncology

STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment

Takayuki Ohkuri et al.

CANCER IMMUNOLOGY RESEARCH (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

Hiroyasu Konno et al.

CELL (2013)

添加到收藏夹

Article Multidisciplinary Sciences

CTLA-4 control over Foxp3+ regulatory T cell function

Kajsa Wing et al.

SCIENCE (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Achieving stability of lipopolysaccharide-induced NF-κB activation

MW Covert et al.

SCIENCE (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.