☆ 4.8 Review

Rational Designs of Biomaterials for Combating Oral Biofilm Infections

ADVANCED MATERIALS (2023)

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Review Food Science & Technology

Zinc homeostasis and regulation: Zinc transmembrane transport through transporters

Shuhua Yin et al.

Summary: Zinc, as a significant micronutrient, plays essential roles in living organisms and is closely associated with disease occurrence. Zinc transporters are crucial in regulating zinc homeostasis, with their structures and dynamics providing insights into the mechanisms of zinc trafficking and regulation. This review elaborates on the structural basis of zinc transport through ZIP and ZnT, the molecular mechanisms of zinc binding and transport, the driving force for zinc transmembrane transport, and the general regulation models of zinc transporters.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Review Materials Science, Multidisciplinary

Antimicrobial micro/nanorobotic materials design: From passive combat to active therapy

Jinhua Li et al.

Summary: The rise of multidrug-resistant bacteria poses a major threat to global public health, as many pathogenic bacteria can form stubborn biofilms and become resistant to antibiotics. Developing novel antibiotics is urgently needed. In response to these challenges, micro/nanorobots with unique characteristics show promise as an alternative to traditional antimicrobial treatments.

MATERIALS SCIENCE & ENGINEERING R-REPORTS (2023)

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Article Biotechnology & Applied Microbiology

Genetically engineered cell membrane-coated nanoparticles for antibacterial and immunoregulatory dual-function treatment of ligature-induced periodontitis

Yangjia Deng et al.

Summary: A biomimetic nanoparticle strategy combining antimicrobial and immunoregulatory effects was successfully developed for the treatment of periodontitis. The results demonstrated that these biomimetic nanoparticles effectively targeted bacteria and suppressed inflammatory activation of macrophages in vitro, as well as attenuated periodontal tissue inflammation and bone loss in a mouse model. This novel approach shows great potential for the treatment of periodontitis and other pathogenic bacterial infections.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

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Article Engineering, Biomedical

Dental plaque-inspired versatile nanosystem for caries prevention and tooth restoration

Yue Xu et al.

Summary: A stimuli-responsive multidrug delivery system has been developed in this study, which can prevent tooth decay and promote enamel restoration. The system can identify cariogenic conditions, intelligently release drugs, and restore the microarchitecture and mechanical properties of demineralized teeth.

BIOACTIVE MATERIALS (2023)

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Article Nanoscience & Nanotechnology

Mussel-Inspired Caries Management Strategy: Constructing a Tribioactive Tooth Surface with Remineralization, Antibiofilm, and Anti-inflammation Activity

Yu Xu et al.

Summary: This study proposes a multifunctional strategy to treat dental caries by constructing a bioactive tooth surface. The Turkish gall extract (TGE) is able to inhibit the adhesion of cariogenic bacteria and destroy biofilms on the tooth surface, while also reducing the expression of inflammatory factors. Furthermore, TGE can induce the growth of hydroxyapatite crystals, leading to the remineralization of enamel and the restoration of mechanical properties.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Review Chemistry, Multidisciplinary

Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine

Marta Overchuk et al.

Summary: Tumoricidal photodynamic (PDT) and photo-thermal (PTT) therapies use light to eliminate cancer cells with precision. The combination of PDT and PTT shows potential due to their different mechanisms of action. Recent developments in multimodal nanoparticles further enhance their efficacy. This review discusses the limitations of each modality alone and how combining them can improve treatment efficacy and safety. It also analyzes the design strategies of dual PDT/PTT nanoparticles and the impact of treatment sequence and dose on treatment response. Additionally, it provides guidelines to elucidate the mechanisms underlying PDT/PTT interactions.

ACS NANO (2023)

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Article Chemistry, Multidisciplinary

Ultrasound Activatable Microbombs via Co-Loading CaO2/Perfluorohexane for Cascade Catalytic Biofilm Disruption and Caries Prevention

Jingmei Guo et al.

Summary: Biofilms are the main cause of most stubborn infections and pose a serious threat to human health. Developing effective strategies to eliminate harmful microbes and stubborn biofilms remains a challenge.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Engineering, Environmental

Versatile hybrid nanoplatforms for treating periodontitis with chemical/photothermal therapy and reactive oxygen species scavenging

Pei Wang et al.

Summary: Given the limitations of clinical curettage for periodontitis, improved medical therapy is needed for thorough removal of dental plaque and periodontal tissue repair. The development of local drug delivery systems (LDDSs) for adjuvant periodontitis therapy has faced challenges such as low anti-biofilm effect and tissue damage caused by excessive reactive oxygen species (ROS). In this study, versatile nanocomposites (PPM NPs) were fabricated using polydopamine-coated Prussian blue nanoparticles (PB NPs) loaded with minocycline (Mino), which showed enhanced antibacterial and anti-inflammatory effects for periodontitis treatment.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Pharmacology & Pharmacy

Enzymatic bionanocatalysts for combating peri-implant biofilm infections by specific heat-amplified chemodynamic therapy and innate immunomodulation

Zheng Su et al.

Summary: A novel non-antibiotic strategy based on the synergy of bionanocatalysts-driven heat-amplified chemodynamic therapy (CDT) and innate immunomodulation is proposed for specific biofilm elimination. The results show that this strategy can precisely eliminate refractory peri-implant biofilm infections with extremely few adverse effects.

DRUG RESISTANCE UPDATES (2023)

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Article Chemistry, Physical

Carvacrol combined with NIR light -responsive nano -drug delivery system with specific anti -bacteria anti -inflammation, and immunomodulation for periodontitis

Daorun Hu et al.

Summary: A carvacrol-based near-infrared light-responsive nano-drug delivery system is developed for the treatment of periodontitis. This system exhibits antibacterial, anti-inflammatory, and immunomodulatory properties and shows promise as a non-invasive management of periodontitis.

NANO RESEARCH (2023)

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Article Engineering, Biomedical

Novel Twin-Crystal Nanosheets with MnO2 Modification to Combat Bacterial Biofilm against Periodontal Infections via Multipattern Strategies

Qiuhan Chen et al.

Summary: Nowadays, significant progress has been made in the multifunctional approaches to kill oral bacteria based on various nanocomposites against periodontal infections. However, the material structure and its functional integration are still insufficient. This study proposes a therapeutic strategy of chemodynamical therapy (CDT) and photothermal therapy (PTT) in monocrystals to effectively enhance the synergistic treatment.

ADVANCED HEALTHCARE MATERIALS (2023)

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Review Microbiology

Recent advances of cell membrane-coated nanoparticles for therapy of bacterial infection

Yue Song et al.

Summary: The rapid evolution of antibiotic resistance and the complicated bacterial infection microenvironments are serious obstacles to traditional antibiotic therapy. Developing novel antibacterial agents or strategy to prevent the occurrence of antibiotic resistance and enhance antibacterial efficiency is of the utmost importance. Cell membrane-coated nanoparticles (CM-NPs) combine the characteristics of the naturally occurring membranes with those of the synthetic core materials, showing great potential for applications in neutralizing toxins, evading immune clearance, targeting specific bacteria, delivering antibiotics, achieving responsive antibiotic release, and eradicating biofilms.

FRONTIERS IN MICROBIOLOGY (2023)

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Article Nanoscience & Nanotechnology

Injectable Tissue-Adhesive Hydrogel for Photothermal/Chemodynamic Synergistic Antibacterial and Wound Healing Promotion

Han Huang et al.

Summary: The development of hydrogel dressings with injectability, adhesion, antibacterial properties, and wound healing promotion is urgently needed. The design of multifunctional injectable hydrogels based on Ag-doped Mo2C-derived polyoxometalate (AgPOM) nanoparticles, urea, gelatin, and tea polyphenols (TPs) has been presented for antibacterial and wound healing acceleration. The hydrogel exhibits excellent tissue adhesion after injection due to the in situ formation triggered by recombination of TPs and gelatin chains. AgPOM in the hydrogel acts as an antimicrobial agent by generating singlet oxygen and sterilizing under near-infrared light. In vitro studies demonstrate high bactericidal ability against drug-resistant Staphylococcus aureus and facilitate wound healing through synergistic photothermal/chemodynamic therapy. Therefore, the injectable hydrogel with AgPOM offers a novel therapeutic agent for drug-resistant bacteria-infected wounds and wound healing promotion.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Engineering, Biomedical

Disruption of biofilms in periodontal disease through the induction of phase transition by cationic dextrans

Yurong Li et al.

Summary: Biofilm formation by oral pathogenic microorganisms can cause periodontitis. The extracellular polymeric substances (EPS) in biofilms act as a protective shield for bacteria, making it challenging to disrupt them. In this study, cationic dextrans were found to induce the phase transition of EPS in biofilms, effectively destroying the biofilm of Porphyromonas gingivalis, a key periodontal pathogen. Promising results were also achieved in a rat periodontal disease model, highlighting the potential of cationic dextrans in treating periodontitis.

ACTA BIOMATERIALIA (2023)

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Review Infectious Diseases

A Local Desiccant Antimicrobial Agent as an Alternative to Adjunctive Antibiotics in the Treatment of Periodontitis: A Narrative Review

Iulia C. Micu et al.

Summary: Periodontitis is a common oral infectious disease caused by the interaction between altered subgingival microbiota and the host's immune-inflammatory response. The goal of periodontal therapy is to eliminate the subgingival biofilm and prevent further tissue breakdown. Adjunctive therapies, including antimicrobials, have been proposed to enhance the effectiveness of mechanical instrumentation. However, these antimicrobials often have side effects and should be used with caution.

ANTIBIOTICS-BASEL (2023)

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Article Medicine, Research & Experimental

Near-infrared light-triggered nitric oxide nanocomposites for photodynamic/photothermal complementary therapy against periodontal biofilm in an animal model

Xiangrong Wu et al.

Summary: Researchers have developed a novel nanocomposite with synergistic photothermal and photodynamic therapy using NO gas. This material shows promising therapeutic effects in treating deep tissue biofilm infections and provides a new solution for other biofilm infection diseases.

THERANOSTICS (2023)

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Article Nanoscience & Nanotechnology

Mesoporous TiO2 Coatings Regulate ZnO Nanoparticle Loading and Zn2+Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Zhuo Wen et al.

Summary: Two major issues hindering the clinical practice of titanium dental implants are immediate/early loading risks and peri-implantitis. In this study, a potential solution was developed using zinc oxide nanoparticle-loaded mesoporous TiO2 coatings (nZnO/MTC-Ti). The coatings controlled the release of Zn2+ and optimized the charge distribution, resolving the cytotoxicity of the nanoparticles and promoting osteogenic activity and inhibiting bacterial infection.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Chemistry, Physical

Carvacrol combined with NIR light-responsive nano-drug delivery system with specific anti-bacteria, anti-inflammation, and immunomodulation for periodontitis

Daorun Hu et al.

Summary: This study developed a near-infrared light-responsive nano-drug delivery system based on carvacrol, which has antibacterial, anti-inflammatory, and immunoregulatory capacities, showing great promise in the clinical practice of periodontitis.

NANO RESEARCH (2023)

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Article Materials Science, Multidisciplinary

Engineered Bdellovibrio bacteriovorus: A countermeasure for biofilm-induced periodontitis

Ying Tang et al.

Summary: By utilizing a material-assisted micro-organism (MAMO) strategy with ZnO nanorods engineered Bdellovibrio (ZnO@Bdello), the biofilm composed of Gram-negative bacteria can be effectively eradicated. This strategy demonstrates superior competence in alleviating inflammation and inhibiting bone resorption.

MATERIALS TODAY (2022)

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Review Microbiology

Tolerance and resistance of microbial biofilms

Oana Ciofu et al.

Summary: Chronic infections caused by microbial biofilms pose a significant clinical challenge due to the resistance of biofilms to antimicrobials and the immune system, leading to persistent and recurrent infections. This Review discusses the current understanding of the mechanisms underlying the tolerance of biofilms to the immune system and to antimicrobials, as well as their role in the development of antimicrobial resistance.

NATURE REVIEWS MICROBIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Synthesis of Spherical Nanoparticle Hybrids via Aerosol Thiol-Ene Photopolymerization and Their Bioconjugation

Narmin Suvarli et al.

Summary: In this study, silver poly(thio-ether) hybrid nanospheres were successfully synthesized using aerosol photopolymerization and thiol-ene chemistry. The stabilized silver nanoparticle dispersion formed nanocomposites with non-agglomerated silver nanoparticles inside polymer spheres. The resulting hybrid nanoparticles were then biofunctionalized and showed potential for use in biosensors and biomedical applications.

NANOMATERIALS (2022)

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Review Chemistry, Multidisciplinary

Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections

Bingqing Jia et al.

Summary: This review provides an overview of nanophysical antimicrobial strategies (NPAS), categorizing them based on the modes of their physical stimulation. The biomedical applications of NPAS in combating bacterial infections are discussed, with a focus on design and antimicrobial mechanisms. Current challenges and future perspectives of NPAS in clinical treatment of bacterial infections are also summarized and discussed, highlighting their potential use in clinical settings.

ADVANCED SCIENCE (2022)

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Article Engineering, Biomedical

Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms

Danfeng Liu et al.

Summary: This study developed a new treatment method for early childhood caries (ECC) by using bioresponsive nanoparticles loaded with chlorin e6, which significantly increased the penetration depth and retention of the photosensitizer in the cariogenic biofilms. This method not only killed bacteria in preformed biofilms but also inhibited multispecies biofilm formation, and showed promising results in in vivo models.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats

Lu Wang et al.

Summary: This study designed a novel dual responsive and dual drug-loading nanocarrier system for precise and controlled drug delivery to treat periodontitis in patients with diabetes. In vitro and in vivo studies confirmed the effectiveness of this nanocarrier, which can inhibit the formation of subgingival microbial colonies and promote osteogenic differentiation of cells, ameliorating periodontal bone resorption.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

An enamel-inspired bioactive material with multiscale structure and antibacterial adhesion property

Hai Ming Wong et al.

Summary: This study aims to fabricate a novel bioactive material with enamel-like structure and antibacterial adhesion property using a non-cell-based biomimetic strategy. The evaporation-based, bottom-up and self-assembly method with layer-by-layer technique were used to form a large-area fluorapatite crystal layer containing antibacterial components. The synthesized bioactive material resembled the native enamel in chemical components, mechanical properties and crystallographic structure, and exhibited antibacterial adhesion property and biocompatibility.

BIOACTIVE MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Dual Action Nitric Oxide and Fluoride Ion-Releasing Hydrogels for Combating Dental Caries

Lori M. Estes Bright et al.

Summary: In this study, a dual-function hydrogel capable of releasing nitric oxide and fluoride was developed for the treatment of dental caries. The hydrogel demonstrated effective antibacterial activity by releasing nitric oxide and prevented enamel demineralization by delivering fluoride ions. It also showed good biocompatibility with human gingival fibroblasts and human osteoblasts.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Swarming Magnetic Photoactive Microrobots for Dental Implant Biofilm Eradication

Carmen C. Mayorga-Martinez et al.

Summary: Efficient eradication of dental biofilm on titanium dental implants can be achieved using swarming magnetic microrobots, demonstrating their potential in precision medicine.

ACS NANO (2022)

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Article Engineering, Biomedical

ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel for the treatment of periodontitis

Yun Liu et al.

Summary: This study constructed an injectable photopolymerizable ZIF-8/gelatin methacryloyl (GelMA) composite hydrogel (GelMA-Z) for the treatment of periodontitis and confirmed its potential prospects in periodontitis treatment.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

Enhanced photocatalytic and antibacterial activity of acridinium-grafted g-C3N4 with broad-spectrum light absorption for antimicrobial photocatalytic therapy

Jiangna Guo et al.

Summary: An acridinium-grafted g-C3N4 (ADN@g-C3N4) with a narrow band gap and broad-spectrum light absorption was synthesized. The narrow optical band gap and improved electrostatic interaction with bacterial lipid bilayer membrane of ADN@g-C3N4 strengthened the ROS generation and facilitated the diffusion of ROS to bacteria surface, leading to enhanced photocatalytic and antibacterial activity against bacteria and corresponding biofilm under light irradiation.

ACTA BIOMATERIALIA (2022)

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Article Dentistry, Oral Surgery & Medicine

Efficacy of scaling and root planning with periodontal endoscopy for residual pockets in the treatment of chronic periodontitis: a randomized controlled clinical trial

Juan Wu et al.

Summary: Periodontal endoscopy during scaling and root planning in chronic periodontitis patients with residual pockets ≥ 5 mm significantly reduces pocket depth and plaque index compared to scaling and root planning alone.

CLINICAL ORAL INVESTIGATIONS (2022)

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Article Chemistry, Multidisciplinary

Spatiotemporal Release of Reactive Oxygen Species and NO for Overcoming Biofilm Heterogeneity

Xue Han et al.

Summary: Heterogeneity in biofilms is a major challenge in biofilm therapies. This study presents a therapeutic strategy that overcomes biofilm heterogeneity by separately loading an antibacterial agent and an EPS dispersant in different compartments of a yolk-shell nanoplatform. The strategy takes advantage of the pharmacokinetic complementarity of ROS and NO to penetrate the biofilm and eliminate bacteria.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Engineering, Biomedical

Injectable hydrogels with high drug loading through B-N coordination and ROS-triggered drug release for efficient treatment of chronic periodontitis in diabetic rats

Xiaodan Zhao et al.

Summary: This study developed a novel injectable local drug delivery system that could improve drug loading efficiency and achieve ROS-triggered drug release. The system exhibited good adhesiveness to gingival tissue, biocompatibility, and significant antibacterial effect. The synergistic effect of doxycycline and metformin was also verified in an animal experiment.

BIOMATERIALS (2022)

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Article Chemistry, Applied

Destructing biofilms by cationic dextran through phase transition

Yurong Li et al.

Summary: Eliminating biofilms from infected tissue is a challenging task in treating chronic wounds. The study found that cationic polymers can disrupt biofilms and enhance bacterial antibiotic sensitivity. In a mouse wound healing model, cationic polymers effectively controlled infection and accelerated the healing process.

CARBOHYDRATE POLYMERS (2022)

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Article Engineering, Environmental

Theory-screened MOF-based single-atom catalysts for facile and effective therapy of biofilm-induced periodontitis

Yi Yu et al.

Summary: This study prepares an injectable ointment based on MOF-based single-atom catalysis systems, which exhibits high anti-biofilm activity and provides a rapid, effective, non-invasive, and convenient strategy for the treatment of periodontitis without antibiotics. The ointment shows superior therapeutic effectiveness compared to the clinically used Periocline.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Multidisciplinary

Additively-manufactured PEEK/HA porous scaffolds with excellent osteogenesis for bone tissue repairing

Jibao Zheng et al.

Summary: PEEK/HA scaffolds improved osseointegration with host bone and enhanced the activity of BMSCs. Micro-CT and histological staining results showed higher bone ingrowth volume and better osteointegration effect of PEEK/HA scaffolds in comparison to pure PEEK scaffolds.

COMPOSITES PART B-ENGINEERING (2022)

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Article Dentistry, Oral Surgery & Medicine

Microrobotics for Precision Biofilm Diagnostics and Treatment

A. Babeer et al.

Summary: Advancements in small-scale robotics and nanotechnology have opened up new possibilities for precise, controllable, and efficient diagnostic and therapeutic approaches. This article describes the design and application of microrobots for biofilm treatment and retrieval, using iron oxide nanoparticles with dual catalytic-magnetic functionality. The microrobots can disrupt and retrieve biofilm samples under magnetic fields and can also be visualized and controlled inside the root canal using radiographic imaging techniques. This concept can be adapted for other hard-to-reach anatomical spaces in an automated and tether-free manner.

JOURNAL OF DENTAL RESEARCH (2022)

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Article Engineering, Environmental

Dissection of the antibacterial mechanism of zinc oxide nanoparticles with manipulable nanoscale morphologies

Xinyi Zhu et al.

Summary: In this study, ZnO nanoparticles with different morphologies were prepared using controllable thermal decomposition, and surface PEGylation was conducted to reduce their biotoxicity. The antibacterial activities of the ZnO nanoparticles were studied using various assays, and the underlying antibacterial mechanism was analyzed through transcriptome analysis. The cost-effective preparation of ZnO nanoparticles with distinct morphological features provides insights for the development of application specific antibacterial agents.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Chemistry, Physical

Versatile graphitic nanozymes for magneto actuated cascade reaction-enhanced treatment of S. mutans biofilms

Qian Dong et al.

Summary: This study designs an integrated nanozyme that can produce highly toxic effects on pathogenic oral biofilms under acidic conditions and inhibits the growth of biofilms through magnetically-driven catalytic activity. These findings provide a simple and effective method to prevent biofilm-induced oral diseases.

NANO RESEARCH (2022)

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Article Chemistry, Multidisciplinary

NIR responsive nitric oxide nanogenerator for enhanced biofilm eradication and inflammation immunotherapy against periodontal diseases

Manlin Qi et al.

Summary: This study successfully developed a near-infrared light triggered nanoplatform with dual functions of antibacterial and anti-inflammatory effects. It can effectively treat periodontal disease by killing bacteria and dispersing biofilms, as well as inhibiting inflammation through the release of gas molecules. The nanoplatform shows promising therapeutic potential for periodontal diseases and other refractory infections in deep tissues.

NANO TODAY (2022)

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Article Chemistry, Multidisciplinary

Light-Propelled Nanorobots for Facial Titanium Implants Biofilms Removal

Martina Ussia et al.

Summary: This study investigates the use of nanorobots to control oral bacterial biofilm on titanium miniplates. The nanorobots exhibit extended absorption and motion actuation from UV to visible-light range, and can effectively reduce the biomass of bacterial biofilm. This research has significant implications for improving the therapy of infected metallic miniplates by biofilm.

SMALL (2022)

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Article Chemistry, Applied

Recent advances in electrocatalytic oxygen reduction for on-site hydrogen peroxide synthesis in acidic media

Jun-Yu Zhang et al.

Summary: This article summarizes recent advances in electrochemical H2O2 production in acidic media, focusing on the two-electron ORR mechanism and different categories of electrocatalysts. It also highlights the innovative development of electrochemical devices and real-time/on-site applications, providing critical perspectives on future research opportunities.

JOURNAL OF ENERGY CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Simultaneous Photodynamic Eradication of Tooth Biofilm and Tooth Whitening with an Aggregation-Induced Emission Luminogen

Meijia Gu et al.

Summary: A highly efficient photodynamic dental therapy strategy is reported, using a photosensitizer with aggregation-induced emission characteristics, which can eradicate tooth biofilm and whiten teeth in a short time with minimal damage to the teeth.

ADVANCED SCIENCE (2022)

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Article Immunology

Lipoxin A4 regulates M1/M2 macrophage polarization via FPR2-IRF pathway

Jixiang Yuan et al.

Summary: LXA4 regulates macrophage polarization by modulating the FPR2-IRF pathway, inhibiting inflammatory polarization of M1 macrophages and promoting IL-4-induced polarization of M2 macrophages.

INFLAMMOPHARMACOLOGY (2022)

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Article Engineering, Biomedical

Photothermal therapy with regulated Nrf2/NF-κB signaling pathway for treating bacteria-induced periodontitis

Yujuan Tian et al.

Summary: In this study, a versatile metal-organic framework (MOF)-based nanoplatform (MPB-BA) was prepared using mesoporous Prussian blue (MPB) nanoparticles to load the immunomodulatory drug BA for the treatment of periodontitis. The results showed that MPB-BA exerted antioxidant and anti-inflammatory effects by scavenging intracellular ROS and switching macrophages phenotype. Moreover, MPB-BA exhibited efficient photothermal antibacterial activity under near-infrared (NIR) light irradiation. In vivo experiments confirmed the superior therapeutic effects of MPB-BA compared to minocycline hydrochloride.

BIOACTIVE MATERIALS (2022)

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Article Engineering, Biomedical

Cyanobacteria-based self-oxygenated photodynamic therapy for anaerobic infection treatment and tissue repair

Bailiang Wang et al.

Summary: Photodynamic therapy (PDT) is an effective treatment for drug-resistant bacterial infections, but the hypoxic environment in certain infections makes it challenging. In this study, cyanobacteria were used as carriers of a photosensitizer and copper oxide nanoparticles, resulting in improved oxygenation and antibacterial properties. In vitro experiments demonstrated the alleviation of the hypoxic environment, and animal models confirmed the successful treatment of infections and promotion of tissue repair.

BIOACTIVE MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Fast Cross-Linked Hydrogel as a Green Light-Activated Photocatalyst for Localized Biofilm Disruption and Brush-Free Tooth Whitening

Qun Li et al.

Summary: This study developed an injectable hydrogel membrane for the simultaneous removal of biofilm and tooth whitening through photodynamic therapy. The hydrogel could form a biofilm removal coating on the tooth surface and release reactive oxygen species under green light, resulting in non-destructive tooth whitening and biofilm eradication.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Manganese Oxide Nanozyme-Doped Diatom for Safe and Efficient Treatment of Peri-Implantitis

Eun-Hyuk Lee et al.

Summary: This article introduces a new method for treating peri-implantitis, which involves using oxygen bubbles to remove biofilm from implants and promote osseointegration without causing harm to surrounding tissues or implant surfaces.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Chemistry, Multidisciplinary

Nanoparticles as Next-Generation Tooth-Whitening Agents: Progress and Perspectives

Dai-Hwan Kim et al.

Summary: This article introduces the use of nanoparticles in tooth whitening and its historical development. It also discusses the classification of nanoparticles and their roles in remineralization and antioxidant effects. The article highlights the significant impact of research and development of nanoparticles in the field of tooth whitening.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Copper Doped Carbon Dots for Addressing Bacterial Biofilm Formation, Wound Infection, and Tooth Staining

Meng Liu et al.

Summary: Oral infectious diseases and tooth staining are major challenges in dental healthcare. Researchers have developed copper-doped carbon dots (Cu-CDs) that can inhibit bacterial adhesion and eradicate biofilms in the oral environment without causing harm to surrounding tissues. Cu-CDs also show excellent antibacterial ability against both Gram-positive and Gram-negative bacteria. In addition, Cu-CDs have a better performance in tooth whitening compared to other alternatives, with minimal damage to enamel and dentin. The biocompatible Cu-CDs have great potential for eliminating oral pathogenic biofilms and promoting oral health.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Surface Topography-Adaptive Robotic Superstructures for Biofilm Removal and Pathogen Detection on Human Teeth

Min Jun Oh et al.

Summary: Scientists have developed a magnetic field-directed self-assembling robotic superstructure called STARS, which can adapt to irregular surface topography and be used for precise removal of biofilms and diagnostic sampling. These superstructures have multiaxis motion and adjustable shape, length, and stiffness, allowing them to scrub adherent biofilms, produce antibacterial reagents, and capture pathogens and matrix components for diagnostic analysis.

ACS NANO (2022)

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Article Materials Science, Multidisciplinary

Constructing an anti-S. mutans and mineralizing membrane by combination self-assembled lysozyme with antimicrobial peptide

Zehui Fang et al.

Summary: A multi-functional membrane formed by the combination of lysozyme and polyphemusin I demonstrates superior abilities in inhibiting the growth of S. mutans and inducing tooth remineralization, offering a promising strategy for preventing dental caries.

MATERIALS & DESIGN (2022)

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Article Biotechnology & Applied Microbiology

Lactobacillus cell envelope-coated nanoparticles for antibiotic delivery against cariogenic biofilm and dental caries

Luting Weng et al.

Summary: This study successfully prepared nanoparticles, called LA/TCS@PLGA-NPs, with favorable properties using cell membrane coating technology and Lactobacillus strains. The nanoparticles were able to adhere to Streptococcus mutans and interfere with its biofilm formation, leading to significant inhibition of the activity, biomass, and virulence gene expression of the biofilms. In vivo experiments also showed that LA/TCS@PLGA-NPs had a long-lasting inhibitory effect on the progression of dental caries. These nanoparticles could be considered as a new class of effective drug delivery systems for caries prevention.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Fucoidan-derived carbon dots against Enterococcus faecalis biofilm and infected dentinal tubules for the treatment of persistent endodontic infections

Shang Tang et al.

Summary: The development of carbon dots (CDs) derived from fucoidan (FD) shows great potential for managing persistent endodontic infections (PEIs). The prepared FDCDs exhibit excellent antibacterial properties and biocompatibility, effectively inhibiting E. faecalis and its biofilm and penetrating into root canals and dentinal tubules to remove located biofilm.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Engineering, Biomedical

NIR-activated nanosystems with self-modulated bacteria targeting for enhanced biofilm eradication and caries prevention

Yunjian Yu et al.

Summary: We have developed a microenvironment-activated nanoplatform for efficient targeted delivery of antimicrobial drugs to oral biofilms. The nanoplatform can penetrate biofilms and release drugs under acidic conditions, resulting in targeted drug delivery to bacteria. Under near-infrared irradiation, the nanoplatform exhibits enhanced biofilm penetration and disruption capabilities compared to drugs alone.

BIOACTIVE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Penetrating Macrophage-Based Nanoformulation for Periodontitis Treatment

Na Yan et al.

Summary: Periodontitis is a chronic inflammatory disease caused by the interaction of oral microorganisms with the host immune response. Porphyromonas gingivalis (P.g.) plays a key role in disrupting the immune system and promoting its own proliferation. In this study, a novel nanoformulation, MZ@PNM@GCP, was developed to target P.g. and effectively treat periodontitis. MZ@PNM@GCP directly killed P.g. by disrupting bacterial structure using cationic nanoparticles and by releasing the antibacterial drug metronidazole (MZ) inside the bacteria. Additionally, MZ@PNM@GCP prevented P.g. from binding to immune cells and neutralized complement component 5a (C5a), thus stopping the subversion of the host immune response. This nanoformulation showed potent efficacy in periodontitis treatment, restoring local immune function and killing pathogenic bacteria, while maintaining good biocompatibility.

ACS NANO (2022)

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Article Engineering, Environmental

Bacterial biofilm microenvironment responsive copper-doped zinc peroxide nanocomposites for enhancing chemodynamic therapy

Yuxiang Zhang et al.

Summary: Dental plaque, a natural biofilm, plays a crucial role in caries and periodontal disease. The pathogenicity of S. mutans is based on the formation of extracellular polysaccharides (EPS) and its survival in acidic environments. Chemodynamic therapy (CDT) is an ideal treatment modality that utilizes the biofilm microenvironment. A novel nanocomposite, ZnO2-Cu@RB NPs, has been developed for enhanced CDT, effectively killing S. mutans in acidic biofilm and reducing demineralization of apatite. Furthermore, it inhibits acid production and EPS formation, showing promising therapeutic efficacy in a rat model.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Multidisciplinary Sciences

Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis

Hanyao Huang et al.

Summary: Periodontitis is a common inflammatory bone loss condition that is associated with systemic diseases. The use of a nanoparticulate cfDNA scavenger shows promise in treating periodontitis by reducing inflammation and bone loss.

NATURE COMMUNICATIONS (2022)

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Article Biotechnology & Applied Microbiology

Antibiofilm activity of ultra-small gold nanoclusters against Fusobacterium nucleatum in dental plaque biofilms

Yangheng Zhang et al.

Summary: Pathogenic dental plaque biofilms are harmful and difficult to treat using conventional methods. Researchers have developed ultra-small gold nanoclusters (AuNCs) that demonstrate strong antibacterial activity against Fusobacterium nucleatum, a key pathogen in dental plaques. AuNCs show promise as effective antibiofilm agents for clinical treatment.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Abalone-Inspired Adhesive and Photo-Responsive Microparticle Delivery Systems for Periodontal Drug Therapy

Chuanhui Song et al.

Summary: Inspired by the suction-cup structures of abalones, a novel adhesive and photo-responsive microparticle delivery system has been developed to treat periodontitis. The system exhibits good adhesion ability and stability, and allows for controlled drug release under near-infrared irradiation.

ADVANCED SCIENCE (2022)

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Article Engineering, Electrical & Electronic

Wearable battery-free theranostic dental patch for wireless intraoral sensing and drug delivery

Zhenghan Shi et al.

Summary: In this study, a wearable dental patch system was developed for monitoring the oral microenvironment and providing controlled fluoride treatment. The system utilizes wireless energy harvesting and data transmission to communicate with mobile terminals, and it can detect acidic microenvironments and deliver fluoride treatment as needed. As a flexible electronic device attached to teeth, this system offers a promising platform for point-of-care monitoring and treatment of dental caries and oral diseases.

NPJ FLEXIBLE ELECTRONICS (2022)

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Article Medicine, Research & Experimental

Dual-sensitive antibacterial peptide nanoparticles prevent dental caries

Peng Zhang et al.

Summary: This study reports dual-sensitive antibacterial peptide nanoparticles for the treatment of dental caries. The nanoparticles showed high efficacy in killing cariogenic bacteria in acidic environments without harming normal oral microbiota. In vivo experiments also demonstrated the superior anti-caries effect of the nanoparticles compared to clinical agents.

THERANOSTICS (2022)

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Review Microbiology

Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Jessa Marie V. Makabenta et al.

Summary: Nanomaterial-based therapies offer a promising approach to combat antibiotic-resistant bacterial infections by targeting biofilms and overcoming recalcitrant infections. Their unique size and physical properties enable them to evade existing mechanisms associated with acquired drug resistance.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Magnetic-Responsive Photosensitizer Nanoplatform for Optimized Inactivation of Dental Caries-Related Biofilms: Technology Development and Proof of Principle

Abdulrahman A. Balhaddad et al.

Summary: MagTBO, a versatile photosensitizer nanoplatform designed in this study, integrates TBO photosensitizer and SPIONs via a microemulsion method to enhance the efficiency of aPDT in targeting bacterial communities embedded within biofilms. The use of an external magnetic field drives the MagTBO microemulsion to penetrate deep into biofilms, improving the photodynamic disinfection effect and demonstrating a promising strategy for intensifying the antibacterial action of photosensitizers against pathogenic oral biofilms.

ACS NANO (2021)

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Review Pharmacology & Pharmacy

Challenges and solutions in polymer drug delivery for bacterial biofilm treatment: A tissue-by-tissue account

Karolina Kasza et al.

Summary: This review highlights the importance of novel antimicrobial approaches in addressing the antibiotic resistance crisis, emphasizing the critical role of biofilms in human infections. Encapsulation within polymeric carriers to enhance treatment efficacy, permeation, and retention at infection sites is a current research focus, but also presents challenges and solutions specific to different tissues.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Oxygen Self-Sufficient Nanoplatform for Enhanced and Selective Antibacterial Photodynamic Therapy against Anaerobe-Induced Periodontal Disease

Xiaolin Sun et al.

Summary: This study presents a smart nanocomposite with oxygen-self-generation for enhanced and selective antibacterial properties against anaerobe-induced periodontal diseases, which successfully applied in combined light-stimulated antimicrobial photodynamic therapy, solving the problem of hypoxic microenvironment.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Diagnosis of biofilm infections: current methods used, challenges and perspectives for the future

N. B. S. Silva et al.

Summary: Diagnosing biofilms remains challenging, with no standardized protocol in clinical practice. Mass spectrophotometry/matrix-assisted laser desorption ionization time of flight (MALDI-TOF) has shown promise, but omics analysis may be a more effective strategy for quicker and more specific identification of pathogens within biofilms. Further research is needed to develop a protocol that ensures rapid and successful biofilm identification.

JOURNAL OF APPLIED MICROBIOLOGY (2021)

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Review Oncology

Photodynamic therapy to control microbial biofilms

Anjali Warrier et al.

Summary: Microorganisms in biofilms show increased resistance to antibiotics, prompting the need for advanced antimicrobial approaches. Photodynamic therapy, as a safe and non-toxic treatment strategy, is increasingly used for chronic infections, extending its potential applications in various medical conditions.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Review Materials Science, Multidisciplinary

Mechanism and factors influence of graphene-based nanomaterials antimicrobial activities and application in dentistry

Asanah Radhi et al.

Summary: Graphene-based nanomaterials (GBNs) have excellent antimicrobial properties by disrupting bacterial cell membrane integrity and generating reactive oxygen species (ROS). The antimicrobial effects of GBNs are influenced by factors such as microbial cell morphology, GBNs characteristics, and concentration. Potential clinical applications of GBNs in dentistry include denture fabrication, restorative treatment, orthodontic treatment, and dental implant treatment.

JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T (2021)

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Article Nanoscience & Nanotechnology

Enhanced Eradication of Bacterial/Fungi Biofilms by Glucose Oxidase-Modified Magnetic Nanoparticles as a Potential Treatment for Persistent Endodontic Infections

Yanjing Ji et al.

Summary: The study demonstrated efficient removal of PEI-related bacterial/fungal biofilms by utilizing glucose oxidase-modified magnetic nanoparticles, showing high antibacterial activity with concentration-dependent effects. The GMNPs showed excellent cytocompatibility and blood compatibility while disrupting bacterial/fungal biofilms through mechanisms such as magnetic field-induced movements and nutrient starvation.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Biotechnology & Applied Microbiology

Self-assembled nanoparticles containing photosensitizer and polycationic brush for synergistic photothermal and photodynamic therapy against periodontitis

Enyu Shi et al.

Summary: A self-assembled nanosystem containing ICG and polycationic brush has shown promising clinical application for synergistic PTT and PDT against periodontitis, exerting excellent antibacterial and anti-periodontitis actions both in vitro and in vivo.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Local drug delivery systems as therapeutic strategies against periodontitis: A systematic review

Ying Wei et al.

Summary: Periodontitis is a common chronic inflammatory disease affecting nearly 60% of the global population, leading to significant oral health issues. Local drug delivery systems (LDDS) show promise as an adjunctive therapy to traditional treatments, offering higher efficacy and fewer side effects in the management of periodontitis.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Materials Science, Multidisciplinary

Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment

Zijun Shen et al.

Summary: Photodynamic therapy is a promising tumor treatment technology, but tumor hypoxia hinders its effectiveness. Various strategies, including oxygen carriers and multimodal therapy, have been explored to overcome the limitations caused by hypoxia and improve therapeutic outcomes.

NPG ASIA MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Functionalized Mouth-Conformable Interfaces for pH Evaluation of the Oral Cavity

Giusy Matzeu et al.

Summary: This paper introduces the incorporation of bioactive materials and colorimetric chemical sensors into oral appliances for real-time monitoring of oral health. This includes using endodontic paper points and dental floss to sense and monitor pH variations. Additionally, edible colorimetric indicators have been developed to create edible devices that visually respond to acidity changes in saliva.

ADVANCED SCIENCE (2021)

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Article Nanoscience & Nanotechnology

A Novel Strategy for Caries Management: Constructing an Antibiofouling and Mineralizing Dual-Bioactive Tooth Surface

Li Zhou et al.

Summary: The novel dual-bioactive peptide constructed by grafting a dentotropic moiety onto an antimicrobial peptide has beneficial functions on tooth surfaces, including inhibiting bacterial adhesion, killing planktonic bacteria, destroying biofilms, protecting teeth, and inducing self-healing regeneration. Molecular dynamics simulations elucidate the main adsorption and mineralization mechanisms, which contribute to its promising potential for preventing dental caries and inducing in situ self-healing remineralization for decayed teeth.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Biofilm-Sensitive Photodynamic Nanoparticles for Enhanced Penetration and Antibacterial Efficiency

Shuangmei Wu et al.

Summary: A pH-sensitive photodynamic nanosystem is designed in this study, which can convert its surface charge in acidic environments to enhance photoinactivation efficiency against gram-negative bacteria, and effectively penetrate and eradicate biofilms under acidic conditions.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

A Bifunctional Zwitterion-Modified Porphyrin for Photodynamic Nondestructive Tooth Whitening and Biofilm Eradication

Hao Zhang et al.

Summary: A bifunctional photodynamic dental therapy (PDDT) strategy based on ZMP has been developed for tooth whitening and biofilm eradication, showing superior ROS output and ability to disintegrate extracellular polymeric substances compared to PP. This new approach highlights the potential of ZMP as a photosensitizer for clinical dentistry in addressing tooth whitening and biofilm-induced dental diseases.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Engineering, Biomedical

Topical treatment of periodontitis using an iongel

Mayuka Nakajima et al.

Summary: IDEA is a deep eutectic antimicrobial ion gel that exhibits deep tissue penetration and antimicrobial activity against P. gingivalis, showing promising topical treatment against periodontitis.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

2D MOF Periodontitis Photodynamic Ion Therapy

Jun Li et al.

Summary: A novel ointment containing 2D MOF nanosheets is designed with enhanced photocatalytic activity, showing strong antimicrobial properties against various oral pathogens. This heterostructure exhibits broad-spectrum antimicrobial activity and superior therapeutic effects, including rapid antibacterial activity, alleviation of inflammation, and improved angiogenesis.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Dentistry, Oral Surgery & Medicine

The oral microbiome: Role of key organisms and complex networks in oral health and disease

Lea Sedghi et al.

PERIODONTOLOGY 2000 (2021)

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Article Materials Science, Biomaterials

A lingering mouthwash with sustained antibiotic release and biofilm eradication for periodontitis

Bohua Li et al.

Summary: A novel mouthwash based on natural polysaccharides was developed to improve drug penetration into dental biofilms, with promising results in killing bacteria and eradicating biofilms in vitro. In an animal model, this mouthwash significantly reduced dental plaque and alleviated inflammation, demonstrating potential benefits for oral infectious diseases.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Review Chemistry, Multidisciplinary

Materials with aggregation-induced emission characteristics for applications in diagnosis, theragnosis, disease mechanism study and personalized medicine

Engui Zhao et al.

Summary: Materials with aggregation-induced emission (AIE) characteristics are widely used in healthcare-related research, showing potential in pre-clinical diagnosis, disease mechanism studies, and photodynamic therapy.

MATERIALS CHEMISTRY FRONTIERS (2021)

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Review Immunology

Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

George Hajishengallis et al.

Summary: Periodontitis is causally linked to the development of other chronic inflammatory diseases outside the oral mucosa, and intervention studies have shown that local treatment of periodontitis can ameliorate surrogate markers of comorbid conditions. Experimental animal studies have further strengthened the potential causal link by establishing biologically plausible and clinically consistent mechanisms. Understanding the impact of disseminated periodontal pathogens and systemic inflammation associated with periodontitis on extra-oral pathologies may lead to new therapeutic options to reduce the risk of periodontitis-associated comorbidities.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Constructing an Antibiofouling and Mineralizing Bioactive Tooth Surface to Protect against Decay and Promote Self-Healing

Li Zhou et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Antibiotic-Free Antibacterial Strategies Enabled by Nanomaterials: Progress and Perspectives

Yue Wang et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Thermal-Disrupting Interface Mitigates Intercellular Cohesion Loss for Accurate Topical Antibacterial Therapy

Benhui Hu et al.

ADVANCED MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Aggregation-Induced Emission: Recent Advances in Materials and Biomedical Applications

Xiaolei Cai et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

Structure-Activity Relationships of Hydroxyapatite-Binding Peptides

Chen Ling et al.

LANGMUIR (2020)

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Article Multidisciplinary Sciences

Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli

Sarah A. Tursi et al.

NATURE COMMUNICATIONS (2020)

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Article Engineering, Biomedical

A biodegradable multifunctional nanofibrous membrane for periodontal tissue regeneration

Xuezhe Liu et al.

ACTA BIOMATERIALIA (2020)

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Article Dentistry, Oral Surgery & Medicine

Adjunctive effect of mouthrinse on treatment of peri-implant mucositis using mechanical debridement: A randomized clinical trial

Juliana Philip et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2020)

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Article Multidisciplinary Sciences

Piezo-catalysis for nondestructive tooth whitening

Yang Wang et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Relief of Biofilm Hypoxia Using an Oxygen Nanocarrier: A New Paradigm for Enhanced Antibiotic Therapy

Hu Dengfeng et al.

ADVANCED SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Controlling Enamel Remineralization by Amyloid-Like Amelogenin Mimics

Dong Wang et al.

ADVANCED MATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Farnesal-loaded pH-sensitive polymeric micelles provided effective prevention and treatment on dental caries

Youping Yi et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Space-Selective Chemodynamic Therapy of CuFe5O8 Nanocubes for Implant-Related Infections

Geyong Guo et al.

ACS NANO (2020)

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Article Engineering, Biomedical

Dual antibacterial drug-loaded nanoparticles synergistically improve treatment of Streptococcus mutans biofilms

Kenneth R. Sims et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

Antimicrobial and anti-inflammatory thermo-reversible hydrogel for periodontal delivery

Bing Wang et al.

ACTA BIOMATERIALIA (2020)

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Review Chemistry, Multidisciplinary

ROS-Scavenging Nanomaterials to Treat Periodontitis

Lihua Sui et al.

FRONTIERS IN CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Chemical Microrobots as Self-Propelled Microbrushes against Dental Biofilm

Katherine Villa et al.

CELL REPORTS PHYSICAL SCIENCE (2020)

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Review Medicine, Research & Experimental

Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives

Linqiang Mei et al.

THERANOSTICS (2020)

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Article Chemistry, Multidisciplinary

Nanoparticles for Oral Biofilm Treatments

Danielle S. W. Benoit et al.

ACS NANO (2019)

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Review Engineering, Biomedical

Photosensitizers for Photodynamic Therapy

Minhuan Lan et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy

Li-Sen Lin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Review Engineering, Biomedical

Rejuvenated Photodynamic Therapy for Bacterial Infections

Qingyan Jia et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Highly Effective and Noninvasive Near-Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

Mu Li et al.

ADVANCED SCIENCE (2019)

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Article Robotics

Catalytic antimicrobial robots for biofilm eradication

Geelsu Hwang et al.

SCIENCE ROBOTICS (2019)

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Review Dentistry, Oral Surgery & Medicine

Advancing antimicrobial strategies for managing oral biofilm infections

Yang Jiao et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2019)

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Article Nanoscience & Nanotechnology

Triple PLGA/PCL Scaffold Modification Including Silver Impregnation, Collagen Coating, and Electrospinning Significantly Improve Biocompatibility, Antimicrobial, and Osteogenic Properties for Orofacial Tissue Regeneration

Yunzhu Qian et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Chemistry, Multidisciplinary

Dual Corona Vesicles with Intrinsic Antibacterial and Enhanced Antibiotic Delivery Capabilities for Effective Treatment of Biofilm-Induced Periodontitis

Yuejing Xi et al.

ACS NANO (2019)

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Article Chemistry, Multidisciplinary

Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

Chao Chen et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Dextran-Coated Iron Oxide Nanoparticles as Biomimetic Catalysts for Localized and pH-Activated Biofilm Disruption

Pratap C. Naha et al.

ACS NANO (2019)

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Review Engineering, Biomedical

Nanoparticles for the Treatment of Oral Biofilms: Current State, Mechanisms, Influencing Factors, and Prospects

Chen Hu et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Near-Infrared Afterglow Luminescent Aggregation-Induced Emission Dots with Ultrahigh Tumor-to-Liver Signal Ratio for Promoted Image-Guided Cancer Surgery

Xiang Ni et al.

NANO LETTERS (2019)

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Review Chemistry, Multidisciplinary

Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

Yong Liu et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Review Immunology

Immunometabolism at the interface between macrophages and pathogens

David G. Russell et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Chemistry, Multidisciplinary

Cell Membrane Coating Nanotechnology

Ronnie H. Fang et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Rapid Biofilm Eradication on Bone Implants Using Red Phosphorus and Near-Infrared Light

Lei Tan et al.

ADVANCED MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Phthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy

Xingshu Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

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Review Dentistry, Oral Surgery & Medicine

Re-osseointegration of Dental Implants After Periimplantitis Treatments: A Systematic Review

Marwa Madi et al.

IMPLANT DENTISTRY (2018)

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Article Multidisciplinary Sciences

Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity

Yuan Liu et al.

NATURE COMMUNICATIONS (2018)

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Review Microbiology

Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease -Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase

Katja Kriebel et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Materials Science, Biomaterials

Bioinspired heptapeptides as functionalized mineralization inducers with enhanced hydroxyapatite affinity

Yuebo Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Review Pharmacology & Pharmacy

Strategies to overcome the polycation dilemma in drug delivery

Andreas Bernkop-Schnuerch

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Article Engineering, Biomedical

Dual purpose hafnium oxide nanoparticles offer imaging Streptococcus mutans dental biofilm and fight it In vivo via a drug free approach

Fatemeh Ostadhossein et al.

BIOMATERIALS (2018)

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Article Multidisciplinary Sciences

Antimicrobial Activities and Mechanisms of Magnesium Oxide Nanoparticles (nMgO) against Pathogenic Bacteria, Yeasts, and Biofilms

Nhu-Y Thi Nguyen et al.

SCIENTIFIC REPORTS (2018)

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Article Chemistry, Multidisciplinary

Phase-Transited Lysozyme as a Universal Route to Bioactive Hydroxyapatite Crystalline Film

Yuan Ha et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Article Chemistry, Multidisciplinary

A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics

Amir Nasajpour et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

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Review Chemistry, Multidisciplinary

Designing Micro- and Nanoswimmers for Specific Applications

Jaideep Katuri et al.

ACCOUNTS OF CHEMICAL RESEARCH (2017)

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Review Immunology

The phagocyte respiratory burst: Historical perspectives and recent advances

David C. Thomas

IMMUNOLOGY LETTERS (2017)

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Article Multidisciplinary Sciences

Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite

Eduardo H. Morales et al.

NATURE COMMUNICATIONS (2017)

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Article Medicine, General & Internal

Periodontal diseases

Denis F. Kinane et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Medicine, General & Internal

Dental caries

Nigel B. Pitts et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

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Article Chemistry, Multidisciplinary

Eradication of Multidrug-Resistant Staphylococcal Infections by Light-Activatable Micellar Nanocarriers in a Murine Model

Yong Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Article Engineering, Biomedical

Nanocatalysts promote Streptococcus mutans biofilm matrix degradation and enhance bacterial killing to suppress dental caries in vivo

Lizeng Gao et al.

BIOMATERIALS (2016)

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Review Microbiology

Biofilms: an emergent form of bacterial life

Hans-Curt Flemming et al.

NATURE REVIEWS MICROBIOLOGY (2016)

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Review Chemistry, Multidisciplinary

Review of Nanomaterials in Dentistry: Interactions with the Oral Microenvironment, Clinical Applications, Hazards, and Benefits

Alexandros Besinis et al.

ACS NANO (2015)

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Article Medicine, General & Internal

Diabetes and periodontitis: A bidirectional relationship

Antonio Bascones-Martinez et al.

MEDICINA CLINICA (2015)

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Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

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Article Biochemistry & Molecular Biology

Hydrogen Peroxide as a Damage Signal in Tissue Injury and Inflammation: Murderer, Mediator, or Messenger?

Albert van der Vliet et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2014)

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Article Chemistry, Multidisciplinary

Synthesis of TiO2 nanotubes with ZnO nanoparticles to achieve antibacterial properties and stem cell compatibility

Wenwen Liu et al.

NANOSCALE (2014)

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Article Chemistry, Multidisciplinary

Ferromagnetic nanoparticles with peroxidase-like activity enhance the cleavage of biological macromolecules for biofilm elimination

Lizeng Gao et al.

NANOSCALE (2014)

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Article Multidisciplinary Sciences

Programmable biofilm-based materials from engineered curli nanofibres

Peter Q. Nguyen et al.

NATURE COMMUNICATIONS (2014)

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Review Dentistry, Oral Surgery & Medicine

Brushing without brushing?-a review of the efficacy of powered toothbrushes in noncontact biofilm removal

Julia C. Schmidt et al.

CLINICAL ORAL INVESTIGATIONS (2013)

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Article Microbiology

Hypoxia Increases Antibiotic Resistance in Pseudomonas aeruginosa through Altering the Composition of Multidrug Efflux Pumps

Bettina Schaible et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

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Review Dentistry, Oral Surgery & Medicine

Recent advances in the development of GTR/GBR membranes for periodontal regeneration-A materials perspective

Marco C. Bottino et al.

DENTAL MATERIALS (2012)

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Article Engineering, Environmental

Diffusion of Nanoparticles in a Biofilm

Thomas-Otavio Peulen et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2011)

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Article Biochemistry & Molecular Biology

Advances in Mucoadhesion and Mucoadhesive Polymers

Vitaliy V. Khutoryanskiy

MACROMOLECULAR BIOSCIENCE (2011)

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Review Endocrinology & Metabolism

Diabetes mellitus and periodontitis: a tale of two common interrelated diseases

Evanthia Lalla et al.

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Review Microbiology

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ANALYTICA CHIMICA ACTA (2009)

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NATURE NANOTECHNOLOGY (2007)

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