4.8 Article

Near-Infrared-II Fluorophore with Inverted Dependence of Fluorescence Quantum Yield on Polarity as Potent Phototheranostics for Fluorescence-Image-Guided Phototherapy of Tumors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Nanoscience & Nanotechnology

Simultaneous Enhancement of the Long-Wavelength NIR-II Brightness and Photothermal Performance of Semiconducting Polymer Nanoparticles

Hongli Zhou et al.

Summary: The study introduces a simple but effective strategy to develop theranostic agents based on semiconductor polymer nanoparticles for long-wavelength NIR-II fluorescence imaging and photothermal therapy, demonstrating improved brightness and photothermal performance with increased repeating unit numbers of semiconducting polymers.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Multidisciplinary

Achieving Efficient NIR-II Type-I Photosensitizers for Photodynamic/Photothermal Therapy upon Regulating Chalcogen Elements

Kaikai Wen et al.

Summary: This study synthesized three chalcogen-element-based donor-acceptor-type semiconducting polymers and tuned their properties to enhance photodynamic effects and superoxide anion generation efficiency, demonstrating unprecedented high-performance in vitro and in vivo.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Acceptor Planarization and Donor Rotation: A Facile Strategy for Realizing Synergistic Cancer Phototherapy via Type I PDT and PTT

Lina Feng et al.

Summary: A strategy of acceptor planarization and donor rotation was proposed to design type I photosensitizers (PSs) and photothermal reagents for tumor therapy. Experimental results showed that nanoparticles with the most rotors exhibited the highest photothermal conversion efficiency, making them suitable for NIR fluorescence imaging-guided synergistic therapy.

ACS NANO (2022)

Article Multidisciplinary Sciences

A supramolecular photosensitizer derived from an Arene-Ru(II) complex self-assembly for NIR activated photodynamic and photothermal therapy

Gang Xu et al.

Summary: The researchers reported a near-infrared supramolecular photosensitizer, RuDA, which can produce singlet oxygen in aggregate state and induce tumor regression in vivo.

NATURE COMMUNICATIONS (2022)

Article Chemistry, Multidisciplinary

Three Birds with One Stone: Acceptor Engineering of Hemicyanine Dye with NIR-II Emission for Synergistic Photodynamic and Photothermal Anticancer Therapy

Wenwen Cao et al.

Summary: This study reports a heavy-atom-free NIR photosensitizer BHcy for synergistic PDT/PTT therapy. BHcy-NPs show efficient singlet oxygen generation and photothermal effect, resulting in significant cancer cell death and tumor growth inhibition.
Article Nanoscience & Nanotechnology

A-DA'D-A Structured Organic Phototheranostics for NIR-II Fluorescence/Photoacoustic Imaging-Guided Photothermal and Photodynamic Synergistic Therapy

Ke Yang et al.

Summary: In this study, a novel organic phototheranostic agent was developed for multimodal imaging-guided combinational phototherapies triggered by a single near-infrared laser. The nanoparticles showed strong light-harvesting ability in the NIR region and were able to conduct NIR-II fluorescence imaging and photoacoustic imaging, as well as perform photothermal therapy and photodynamic therapy simultaneously. In vitro and in vivo experiments demonstrated that the nanoparticles significantly inhibited tumor cell growth without apparent toxic side effects under laser irradiation.

ACS APPLIED MATERIALS & INTERFACES (2022)

Article Chemistry, Multidisciplinary

A New Class of NIR-II Gold Nanocluster-Based Protein Biolabels for In Vivo Tumor-Targeted Imaging

Xiaorong Song et al.

Summary: The development of bright NIR-II luminescent nanomaterials for efficient protein labelling in vivo without altering their physiological properties is challenging. The synthesized CD-Au NCs can label proteins/antibodies effectively and enable highly efficient in vivo tracking, leading to sensitive tumor-targeted imaging. Additionally, they exhibit good biocompatibility and high renal clearance efficiency in harsh biological environments.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

Polymethine-Based Semiconducting Polymer Dots with Narrow-Band Emission and Absorption/Emission Maxima at NIR-II for Bioimaging

Ming-Ho Liu et al.

Summary: This study presents semiconductor polymers with emission characteristics in the NIR-IIa window, which show potential for high-resolution, noninvasive brain imaging in live mice and offer a platform for future design of NIR-IIa or even NIR-IIb emitting Pdots.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

A Tumor-Targeting Near-Infrared Heptamethine Cyanine Photosensitizer with Twisted Molecular Structure for Enhanced Imaging-Guided Cancer Phototherapy

Xiujie Zhao et al.

Summary: Utilizing a twisted structure of TPE to enhance the photothermal conversion efficiency of IR780, the obtained molecule T780T shows strong NIR fluorescence and improved PCE. T780T exhibits excellent photothermal stability and ROS generation capability in the dispersed state, and can be formulated into uniform nanoaggregates in aqueous phase for potential clinical applications.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Article Chemistry, Multidisciplinary

Improving Image-Guided Surgical and Immunological Tumor Treatment Efficacy by Photothermal and Photodynamic Therapies Based on a Multifunctional NIR AIEgen

Ruming Jiang et al.

Summary: Multimodal therapy using a multifunctional theranostic nanoplatform based on AIEgen enables preoperative diagnosis, intraoperative fluorescence-guided surgery, and photodynamic and photothermal therapies to efficiently kill tumor cells and significantly improve survival rates.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Tailored Engineering of Novel Xanthonium Polymethine Dyes for Synergetic PDT and PTT Triggered by 1064 nm Laser toward Deep-Seated Tumors

Hui Bian et al.

Summary: In this study, five novel NIR-II dyes were successfully developed with intense absorption ranging from 890 to 1206 nm, strong singlet oxygen generation capability, and fluorescence imaging ability triggered by a single NIR-II light. Among them, BH 1024 showed the best performance in singlet oxygen generation, moderate photothermal heating, and considerable fluorescence under 1064 nm laser irradiation. Encapsulating BH 1024 into folate-functionalized polymer demonstrated a synergetic PDT/PTT effect in vitro and in vivo, eventually achieving solid tumors elimination under NIR-II fluorescence guide. This is the first attempt to explore and design small molecular dyes for NIR-II PDT or NIR-II PDT/PTT.
Article Engineering, Biomedical

One-for-all phototheranostics: Single component AIE dots as multi-modality theranostic agent for fluorescence-photoacoustic imaging-guided synergistic cancer therapy

Haifei Wen et al.

Summary: This study successfully constructs a versatile theranostic agent with aggregation-induced emission (AIE) characteristics, providing both multimodality imaging and therapy functions. The theranostic agent exhibits good biocompatibility and excellent therapeutic efficacy, making it a promising platform for practical cancer diagnosis and treatment.

BIOMATERIALS (2021)

Article Materials Science, Biomaterials

Novel NIR-II semiconducting molecule incorporating sorafenib for imaging guided synergetic cancer phototherapy and anti-angiogenic therapy†

Huihui Zou et al.

Summary: An organic semiconducting molecule named T8IC was developed for potential phototheranostics in the second near-infrared window. By incorporating anti-angiogenic agent sorafenib, TS nanoparticles with synergistic anti-angiogenic and phototheranostic effects were formed. The TS nanoparticles showed excellent deep tumor imaging and photothermal therapy capabilities.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Pharmacology & Pharmacy

Multifunctional Nanotheranostic Agent for NIR-II Imaging-Guided Synergetic Photothermal/Photodynamic Therapy

Tuanwei Li et al.

Summary: A NIR (NIR-I) probe with intrinsic multifunctionality was synthesized and encapsulated in an amphiphilic polypeptide to create polymeric micelles serving as a nanotheranostic platform for NIR-II imaging-guided photothermal therapy (PTT) and photodynamic therapy (PDT). In vivo studies demonstrated the real-time monitoring of P@BDP accumulation in tumors and the highly effective synergistic phototherapy under NIR-II imaging-guided PTT/PDT combination therapy.

ADVANCED THERAPEUTICS (2021)

Article Chemistry, Multidisciplinary

Multiplexed NIR-II Probes for Lymph Node-Invaded Cancer Detection and Imaging-Guided Surgery

Rui Tian et al.

ADVANCED MATERIALS (2020)

Article Chemistry, Multidisciplinary

Tumor Microenvironment-Activated NIR-II Nanotheranostic System for Precise Diagnosis and Treatment of Peritoneal Metastasis

Sisi Ling et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Fluorination Enhances NIR-II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging

Ye Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

An NIR-II-Emissive Photosensitizer for Hypoxia-Tolerant Photodynamic Theranostics

Lanqing Li et al.

ADVANCED MATERIALS (2020)

Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Chemistry, Multidisciplinary

Design, Synthesis, and Application of a Small Molecular NIR-II Fluorophore with Maximal Emission beyond 1200 nm

Yu Fang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Materials Science, Multidisciplinary

Single-crystal field-effect transistors based on a fused-ring electron acceptor with high ambipolar mobilities

Chengyi Xiao et al.

JOURNAL OF MATERIALS CHEMISTRY C (2020)

Article Multidisciplinary Sciences

Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing

Shangfeng Wang et al.

NATURE COMMUNICATIONS (2019)

Article Nanoscience & Nanotechnology

An organic NIR-II nanofluorophore with aggregation-induced emission characteristics for in vivo fluorescence imaging

Wei Wu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

Article Biotechnology & Applied Microbiology

In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles

Yeteng Zhong et al.

NATURE BIOTECHNOLOGY (2019)

Article Multidisciplinary Sciences

Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

Yue Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Chemistry, Multidisciplinary

Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission

Ge Xu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Article Chemistry, Multidisciplinary

Donor Engineering for NIR-II Molecular Fluorophores with Enhanced Fluorescent Performance

Qinglai Yang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Multidisciplinary Sciences

Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green

Jessica A. Carr et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues

Hao Wan et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Physical

Evaluation of Spin-Orbit Couplings with Linear-Response Time-Dependent Density Functional Methods

Xing Gao et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2017)

Article Chemistry, Multidisciplinary

Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window

Sanghwa Jeong et al.

NANO LETTERS (2017)

Article Chemistry, Multidisciplinary

Rational Design of Molecular Fluorophores for Biological Imaging in the NIR-II Window

Qinglai Yang et al.

ADVANCED MATERIALS (2017)

Article Chemistry, Multidisciplinary

A PEGylation-Free Biomimetic Porphyrin Nanoplatform for Personalized Cancer Theranostics

Liyang Cui et al.

ACS NANO (2015)

Article Chemistry, Multidisciplinary

Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors

Yanyan Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Engineering, Biomedical

Dual imaging-guided photothermal/photodynamic therapy using micelles

Miao Guo et al.

BIOMATERIALS (2014)

Article Multidisciplinary Sciences

Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes

Debadyuti Ghosh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Chemistry, Multidisciplinary

Near-Infrared Absorbing Polymeric Nanoparticles as a Versatile Drug Carrier for Cancer Combination Therapy

Hua Gong et al.

ADVANCED FUNCTIONAL MATERIALS (2013)

Article Chemistry, Multidisciplinary

In Vivo Fluorescence Imaging in the Second Near-Infrared Window with Long Circulating Carbon Nanotubes Capable of Ultrahigh Tumor Uptake

Joshua T. Robinson et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Biochemistry & Molecular Biology

Multifunctional in vivo vascular imaging using near-infrared II fluorescence

Guosong Hong et al.

NATURE MEDICINE (2012)

Review Chemistry, Multidisciplinary

Spin-orbit coupling and intersystem crossing in molecules

Christel M. Marian

WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE (2012)

Article Multidisciplinary Sciences

Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window

Kevin Welsher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)