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Article
Chemistry, Multidisciplinary
Han-Chao Zhang et al.
Summary: Studying the relationship between structure and activity in bio-enzymes is important for designing nanozymes for energy and environmental applications. In this study, Fe single-atom nanozymes (Fe-SANs) with Fe-N-5 site, inspired by cytochromes P450 (CYPs), have been developed and characterized. The Fe-SANs exhibit excellent activity and selectivity in the oxidation of sulfamethoxazole, a typical antibiotic contaminant.
Article
Chemistry, Multidisciplinary
Kang Kim et al.
Summary: This study reports the synthesis of edge-rich Fe single-atom nanozymes (FeNC-edge) through H2O2-mediated edge generation. By controlling the number of edge sites, the peroxidase (POD)- and oxidase (OXD)-like performance is significantly enhanced. Experimental results and density functional theory (DFT) calculations reveal the high electron density of Fe atoms and open N atoms in the FeN4 moieties at the edge sites. Finally, it is demonstrated that FeNC-edge nanozyme effectively inhibits tumor growth both in vitro and in vivo, suggesting that edge-tailoring is an efficient strategy for developing artificial enzymes as novel catalytic therapeutics.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Chao Peng et al.
Summary: Nanozymes, a class of nanomaterials mimicking the function of enzymes, have gained much attention due to their arbitrarily tunable features. Single-atom nanozymes (SAzymes) with well-defined structures provide an important bridge to study the mechanism and relationship between structure and catalytic activity. They have emerged as a promising alternative to natural enzymes, with applications ranging from bioanalytical tools to in vivo therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dongdong Wang et al.
Summary: Researchers develop a facile missing-linker-confined coordination strategy to fabricate two self-assembled nanozymes: conventional nanozyme (NE) and single-atomic nanozyme (SAE). They consist of Pt nanoparticles and single Pt atoms as active catalytic sites anchored in metal-organic frameworks (MOFs) with encapsulated photosensitizers for catalase-mimicking enhanced photodynamic therapy. Compared to a Pt nanoparticle-based conventional nanozyme, a Pt single-atomic nanozyme shows enhanced catalase-mimicking activity in generating oxygen for overcoming tumor hypoxia, exhibiting more efficient reactive oxygen species generation and higher tumor inhibition rate.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yuanjun Chen et al.
Summary: Nanozymes mimic the active centers of natural enzymes. However, their catalytic performance falls short compared to natural enzymes. This study demonstrates that precise control over the atomic configuration of Co single-atom nanozymes enables the rational regulation of their catalase-like performance. The findings highlight the potential of precise control over nanozyme active centers for mimicking the evolved active sites of natural enzymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yang Liu et al.
Summary: Immunotherapy is a promising treatment strategy for tumor regression, but it has low response rates due to the lack of immunogenicity in tumor cells. This study presents a strategy to enhance the immunogenicity of tumor cells by inducing cascade immunogenic tumor ferroptosis. A nanoplatform was developed to trigger lipid peroxidation and activate ACSL4, resulting in irreversible cascade immunogenic ferroptosis. This approach could overcome the limitations of current immunotherapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Jie Zhou et al.
Summary: A coordination driven self-assembly strategy using L-cysteine was presented to activate PVP-modified Cu single-atom nanozymes for catalytic tumor-specific therapy. The optimized catalase-like activity of the nanozymes was achieved by modulating the Cu single atom content and the L-Cys-Cu center dot center dot center dot O active sites. The nanozymes exhibited significantly higher catalytic efficiency compared to typical MnO2 nanozymes and natural catalase.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yachen Deng et al.
Summary: A series of single-Sn-atom catalysts with well-defined structures were developed as model systems to explore their electrochemical reactivity toward CO2RR. The selectivity and activity of CO2 reduction to formic acid on Sn-single-atom sites were found to be correlated with Sn(IV)-N4 moieties axially coordinated with oxygen (O-Sn-N4), achieving an optimal HCOOH Faradaic efficiency of 89.4% with a partial current density (jHCOOH) of 74.8 mA·cm-2 at -1.0 V vs RHE. Surface-bound bidentate tin carbonate species were captured during CO2RR, and the electronic and coordination structures of the single-Sn-atom species under reaction conditions were determined.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Lu Zhang et al.
Summary: Nanozymes with intrinsic enzyme-mimicking activities have the potential to become surrogates of natural enzymes. However, their catalytic efficacy and practical application under physiological conditions are inferior to that of natural enzymes. Recent studies have introduced biosystem-inspired strategies to optimize the functions of nanozymes in biomedical settings. This review introduces the engineering of biosystem-inspired nanozymes and discusses their biomedical applications, as well as the opportunities and challenges in their design and application.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yang Liu et al.
Summary: Nanozyme catalytic therapy triggered by tumor-specific endogenous stimuli is limited by the catalytic efficiency and concentration of substrates. Researchers developed a novel and efficient Ir-N-5 single-atom nanozyme with multiple enzyme-like activities. The Ir-N-5 SA exhibited better catalytic performance and could generate reactive oxygen species and other reactions, realizing efficient nanozyme catalytic therapy in a substrate-cycle manner. The Ir-N-5 SA/Cer nanoagent disrupted redox and metabolic homeostasis in the tumor region, overcoming the limitations of current nanozyme catalytic therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Mai Hattori et al.
Summary: Metal poly(heptazine imide) (MPHI) has various optoelectronic functions by accommodating different metal ions, but the mechanisms responsible for its unique properties, such as high photo-catalytic activity, photochromism, and photoconduction, remain unknown. This study focuses on investigating the mechanisms of photochromism and photoconduction in potassium PHI (KPHI) by gradually replacing K+ with H+ to prepare samples with tunable K+ concentrations. The properties of these samples were thoroughly investigated through experiments and calculations.
CHEMISTRY OF MATERIALS
(2023)
Article
Multidisciplinary Sciences
Yan Shen et al.
Summary: A photocatalyst for CO2 reduction to C3H8 is prepared by implanting Cu single atoms on vacancy rich TiO2 single layers, which stabilizes key reaction intermediates and promotes C-C bond formation. By implanting Cu single atoms on Ti0.91O2 atomically-thin single layers and forming Cu-Ti-V-O unit, an efficient photocatalyst for the conversion of CO2 into C3H8 is achieved, with high electron-based and product-based selectivity.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Bolong Xu et al.
Summary: Single-atom nanozymes are a new research frontier in the biomedical fields. A melamine-mediated pyrolysis activation strategy has been used to controllably fabricate iron-based SAzymes with a five-coordinated structure (FeN5). The FeN5 SAzyme shows excellent peroxidase-like activity and significantly enhanced antitumor effect in vitro and in vivo.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Julia Kroeger et al.
Summary: The influence of different counterions on the conductivity and photocatalytic activity of 2D carbon nitride poly(heptazine imide) (PHI) was investigated. Na-PHI showed superior conductivity and photocatalytic activity compared to other M-PHIs, likely due to the geometry and size of the ions in the pores. Increasing relative humidity resulted in significant improvements in both ionic conductivity and photocatalytic activity.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Gianvito Vile et al.
Summary: This study reports the high catalytic performance of a family of Cu-based single-atom catalysts for triazole synthesis. The use of a carbon nitride carrier as a ligand for atomically dispersed copper species improves the catalyst activity and selectivity.
Article
Chemistry, Multidisciplinary
Yuan Chen et al.
Summary: This study presents a single-atom nanozyme Cu SAs/CN with APX-like behavior, showing comparable activity and kinetics to natural APXs. Through density functional theory, the Cu-N-4 moieties in the active center of Cu SAs/CN are determined to facilitate the activation and cleavage of H2O2 molecules, resulting in fast kinetics.
Article
Chemistry, Multidisciplinary
Chong-Bo Ma et al.
Summary: This study presents a facile synthetic strategy for a dual single-atom nanozyme composed of zinc (Zn) and molybdenum (Mo). The nanozyme utilizes polyoxometalates and supramolecular coordination complexes as metal-atom precursors, and an amphiphilic aerogel as the supporting substrate. The dual single-atoms of Zn and Mo exhibit a synergistic effect and peroxidase-like activity. The nanozyme shows outstanding stability and is capable of detecting various analytes in different samples.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Marcos A. R. da Silva et al.
Summary: This study presents an alternative method for the preparation of highly active Fe single-atom catalysts (SACs) with Fe-N4 sites, which exhibit high selectivity in the oxidation of C-H bonds. The catalyst obtained through ion exchange can effectively oxidize C-H bonds to ketones under light irradiation.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Review
Chemistry, Physical
Xiaobo Zheng et al.
Summary: This review comprehensively outlines the recent exciting advances on novel atomically dispersed metal catalysts (NADMCs) with emphasis on understanding the synergistic interactions among multiple metal atoms and underlying structure-performance relationships. It discusses the synthetic approaches, characterizations, and energy-related applications of NADMCs, and provides insights into the remaining challenges and opportunities for their development.
Article
Chemistry, Multidisciplinary
Shuangfei Cai et al.
Summary: Nanocatalytic therapy, involving nanozyme-triggered production of reactive oxygen species (ROS) in the tumor microenvironment, has potential in tumor therapy. However, nanozymes still face challenges of activity and specificity. This study introduces a strategy based on a single-atom nanozyme for cascade enzymatic reactions in the tumor microenvironment, showing promising results in efficient tumor therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Runze Li et al.
Summary: This article discusses the key factors affecting the catalytic performance of metal-based atomically dispersed catalysts and their relationship with the active sites. It first introduces the effectiveness of active site design through coordination effects, then discusses the role of chemical bonds in the active sites and the influence of the spacing of active atoms in intermetallic compounds on catalytic behavior. Additionally, the importance of synergistic effects in catalyst design is emphasized, and the key parameters affecting catalytic performance at the atomic scale are summarized.
Article
Chemistry, Multidisciplinary
Mengyu Chang et al.
Summary: In this study, a polyporous Cu single atom nanozyme loaded with licogliflozin (LIK066) was designed to achieve efficient mild photothermal therapy (PTT) by inhibiting heat shock proteins (HSPs) synthesis and damaging existing HSPs in cancer cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Bing Jiang et al.
Summary: Nanozymes with intrinsic enzyme-like properties have attracted significant interest due to their potential to address the limitations of traditional enzymes, but their activity is generally lower than natural enzymes. Single-atom nanozymes (SAzymes) with well-defined electronic and geometric structures have shown promise as direct surrogates of traditional enzymes.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Changyu Cao et al.
Summary: A novel all-in-one Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is designed for synergistic chemodynamic, photodynamic, and photothermal therapy in the tumor microenvironment, demonstrating outstanding therapeutic outcomes. The mechanisms of intraparticulate interactions, sustainability, and self-replenishment are carefully revealed, providing new insights into the design of novel nanozymes for efficient nanocatalytic therapy with high specificity and low side effects.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Gang Wang et al.
Summary: The efficient separation of photo-generated electrons and holes is achieved by utilizing a dual atomic sites strategy on polymeric carbon nitride, which significantly enhances photocatalytic performance. This study provides a new perspective for the rational design of high performance photocatalysts at atomic level.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Physical
Julia Kroeger et al.
Summary: This study reports the first postsynthetic modification of 2D carbon nitride poly(heptazine imide) using terminal melamine moieties. The covalent attachment of these groups improves the colloidal stability and photocatalytic performance of the catalyst particles.
ADVANCED ENERGY MATERIALS
(2021)
Article
Multidisciplinary Sciences
Feng Gao et al.
Summary: The study shows that nanozymes that generate surface-bound ROS can selectively kill bacteria without harming mammalian cells, offering great potential for antimicrobial applications.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Mengyu Chang et al.
Summary: Photothermal therapy (PTT) is a promising tumor therapeutic modality, but minimizing damage to healthy tissues while maximizing efficiency is crucial. Utilizing a single-atom nanozyme (SAzyme) can improve the effectiveness of mild PTT by promoting ferroptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Shufang Ji et al.
Summary: By precisely controlling the electronic structure of the single-atom iron active center, FeN3P-SAzyme exhibits catalytic activity and kinetics comparable to natural enzymes, showing promising potential as an effective therapeutic strategy for inhibiting tumor cell growth.
Article
Chemistry, Analytical
Weiqing Xu et al.
Summary: The study designed a coordination structure of Fe-N-C single-atom catalysts, with the axial ligand-engineered NG-Heme showing superior enzyme-like activity, vividly mimicking the active sites of peroxidase and being applicable in clinical sample analysis.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yahui Wu et al.
Summary: Guided by first-principles calculations, it was discovered that Cd single-atom catalysts have excellent performance in activating CO2, and the introduction of axial coordination structure can further decrease the free energy barrier of CO2 reduction while suppressing the hydrogen evolution reaction. The designed and synthesized novel Cd SAC showed outstanding performance in CO2 electroreduction to CO, achieving a high faradaic efficiency and turnover frequency. This work serves as a successful example of designing highly efficient catalysts guided by theoretical calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yu Ouyang et al.
Summary: The covalent linkage of aptamer binding sites to nanoparticle nanozymes improves catalytic activity by concentrating reaction substrates at the core, mimicking native enzymes. Aptamer-modified Cu2+ ion-functionalized C-dots show superior catalytic activity as aptananozymes, with enhanced functions controlled by the aptamer structure. Chiroselective catalysis and mechanistic studies are also discussed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Yu Lin et al.
Summary: A visible light-stimulated efficient nanozyme system, TiO2 nanotubes coated with MoS2 nanoflowers, was discovered for significant bacterial treatment. By narrowing the bandgap of TiO2NTs and enhancing the peroxidase-like activity of MoS2, a higher photocatalytic efficiency was achieved. The TiO2NTs@MoS2 nanocomposite showed outstanding antibacterial effects under visible light, demonstrating its potential for wound healing infected with drug-resistant bacteria.
Review
Chemistry, Multidisciplinary
Lei Jiao et al.
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(2020)
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(2020)
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Multidisciplinary Sciences
Liang Huang et al.
Review
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Bowen Yang et al.
ADVANCED MATERIALS
(2019)
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Hendrik Schlomberg et al.
CHEMISTRY OF MATERIALS
(2019)
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Guigang Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
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Juqun Xi et al.
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Guigang Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
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Honghui Ou et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
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Zupeng Chen et al.
ADVANCED MATERIALS
(2017)
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Xiaoning Li et al.
Article
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NATURE NANOTECHNOLOGY
(2007)
