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Nanoparticle-Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

ADVANCED MATERIALS (2023)

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Article Immunology

Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity

Paolo D. A. Vignali et al.

Summary: CD8(+) T cells play a crucial role in cancer cell elimination. Exhaustion, a hypofunctional state, can be induced in these cells by factors in the tumor microenvironment (TME). Highly exhausted T (tT(ex)) cells, resistant to checkpoint blockade immunotherapy, resemble CD4(+)Foxp3(+) regulatory T cells and suppress T cell proliferation through CD39-generated immunosuppressive adenosine. Restricting CD39 in endogenous CD8(+) T cells slows tumor progression, improves immunotherapy response, and enhances infiltration of tumor-specific T cells. Induced by tumor hypoxia, CD39 expression on tT(ex) cells can be mitigated to reduce their suppressive effects. Hence, targeting or eliminating tT(ex) cells in the TME could enhance immunotherapy efficacy.

NATURE IMMUNOLOGY (2023)

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Review Biotechnology & Applied Microbiology

Targeting HER2-positive breast cancer: advances and future directions

Sandra M. Swain et al.

Summary: The discovery of the monoclonal antibody trastuzumab almost 25 years ago revolutionized treatment and drug development for HER2(+) breast cancer. Here, Swain et al. review the current standard of care for HER2(+) breast cancer, describe mechanisms of drug resistance, and focus on next-generation platforms and therapies for the treatment of this disease.

NATURE REVIEWS DRUG DISCOVERY (2023)

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Review Oncology

Gold nanoparticles-based photothermal therapy for breast cancer

Mohammed Ali Dheyab et al.

Summary: AuNPs-mediated photothermal therapy (PTT) is gaining popularity due to its easily-tuned features and potential in breast cancer treatment. However, certain challenges, such as non-specificity and low photothermal conversion effectiveness, need to be addressed. This study provides a comprehensive overview of recent advancements in AuNPs for PTT, focusing on breast cancer cells. It discusses the different types of AuNPs, their benefits and drawbacks, as well as the potential challenges and future developments in clinical applications.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2023)

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Article Chemistry, Multidisciplinary

Pancreatic Tumor-Targeting Stemsome Therapeutics

Jun-Young Park et al.

Summary: Due to stem cells' ability to specifically target tumor environments, stem-cell-membrane-functionalized nanocarriers can be used for targeted delivery of active anticancer drugs. This study focuses on self-targeting pancreatic cancer cells using stem cells. By utilizing the targeting abilities of stem cells, nano-polylactide-co-glycolide loaded with doxorubicin can be encapsulated within stem cell membranes, leading to targeted reduction of deep pancreatic tumor tissues. This platform technology can be applied to malignant tumors lacking surface target receptors, such as pancreatic tumor cells.

ADVANCED MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Trojan Horse Phototheranostics: Fine-Engineering NIR-II AIEgen Camouflaged by Cancer Cell Membrane for Homologous-Targeting Multimodal Imaging-Guided Phototherapy

Jie Cui et al.

Summary: This study successfully developed a versatile molecule DHTDP with aggregation-induced emission, which can simultaneously exhibit second near-infrared (NIR-II) fluorescence emission and efficient photothermal conversion. By camouflaging DHTDP nanoparticles with cancer cell membrane, the resultant biomimetic nanoparticles not only have facilitated delivery efficiency and homologous targeting capability, but also provide precise imaging guidance through NIR-II fluorescence imaging, photoacoustic imaging, and photothermal imaging. This study presents a new approach to explore superior phototheranostics for practical cancer theranostics using biomimetic multimodal phototheranostics loaded by homogeneity-targeting cell membrane.

ADVANCED MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Defect-Rich MoSe2 2H/1T Hybrid Nanoparticles Prepared from Femtosecond Laser Ablation in Liquid and Their Enhanced Photothermal Conversion Efficiencies

Fan Ye et al.

Summary: MoSe2 2H/1T hybrid nanoparticles are synthesized by laser ablation of MoSe2 powder and their formation mechanism and photothermal conversion efficiencies (PTCEs) are investigated. Two types of nanoparticles are observed: onion-structured nanoparticles formed by nucleation on melted droplets and polycrystalline nanoparticles formed by coalescence of crystalline nanoclusters. The nanoparticle size distribution corresponds to different fragmentation mechanisms. The PTCEs increase with laser power and ablation time and can reach up to 38%. The high PTCEs are attributed to defects and structural disorder in the nanoparticles.

ADVANCED MATERIALS (2023)

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Article Engineering, Biomedical

Rational design of pH-activated upconversion luminescent nanoprobes for bioimaging of tumor acidic microenvironment and the enhancement of photothermal therapy

Baojin Tan et al.

Summary: In this study, tumor microenvironment-activatable self-assembling organic nanotheranostics were synthesized for precise tumor targeting and upconversion image-guided photothermal therapy. The nanotheranostics showed high sensitivity and selectivity in the acidic tumor microenvironment, allowing for enhanced upconversion luminescence and photothermal effect. This research provides a new approach for the development of activatable therapeutic nanoplatforms.

ACTA BIOMATERIALIA (2023)

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Article Chemistry, Multidisciplinary

Fluorination Enhances NIR-II Emission and Photothermal Conversion Efficiency of Phototheranostic Agents for Imaging-Guided Cancer Therapy

Chunbin Li et al.

Summary: This study proposes a fluorination strategy for designing phototheranostic agents (PTAs) with improved fluorescence quantum yield (QY) and photothermal conversion efficiency (PCE). The experimental results showed that the fluorinated PTAs nanoparticles (NPs) had increased molar extinction coefficient (epsilon), NIR-II QY, and PCE compared to the chlorinated counterparts. Theoretical calculations suggested that fluorination could maximize the electrostatic potential difference, enhance intra/intermolecular interactions, and tighten molecule packing, leading to the simultaneous enhancement of QY and PCE. The fluorinated PTAs nanoparticles demonstrated high performance in high-resolution imaging and photothermal therapy of tumors. This study provides valuable guidance for constructing high-performance NIR-II organic PTAs.

ADVANCED MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Near-Infrared Nano-Optogenetic Activation of Cancer Immunotherapy via Engineered Bacteria

Xiaoqiang Zhu et al.

Summary: Researchers have developed a bacteria-based cancer immunotherapy using engineered Escherichia coli and lanthanide upconversion nanoparticles. By combining optogenetic tools with the natural behavior of certain bacteria, this novel therapy achieved significant tumor regression with no side effects.

ADVANCED MATERIALS (2023)

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Article Polymer Science

Emerging application of magnetic nanoparticles for breast cancer therapy

Tenzin Tsering Dongsar et al.

Summary: Breast carcinoma is a highly prevalent and deadly cancer in females, causing a significant number of mortalities and incidences. Conventional cancer treatments have limitations in terms of side effects and efficacy. Nanotechnology, specifically magnetic nanoparticles (MNPs), has emerged as an innovative approach for cancer management and detection. This article summarizes the applications of MNPs in cancer therapy, focusing on the potential of MNPs in treating breast cancer.

EUROPEAN POLYMER JOURNAL (2023)

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Article Oncology

Effect of preoperative chemotherapy on the outcome of women with operable breast cancer

Bernard Fisher et al.

Summary: This study compares the efficacy of preoperative and postoperative chemotherapy in women with primary operable breast cancer, and explores the correlation between tumor response to preoperative chemotherapy and prognosis. The results showed no significant difference in DFS, DDFS, or survival between the preoperative and postoperative chemotherapy groups. Preoperative chemotherapy allows for more lumpectomies and tumor response is associated with prognosis.

JOURNAL OF CLINICAL ONCOLOGY (2023)

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Article Chemistry, Physical

P-selectin-targeted nanocarriers induce active crossing of the blood-brain barrier via caveolin-1-dependent transcytosis

Daniel. E. Tylawsky et al.

Summary: This study demonstrates a novel nanotherapeutic approach using fucoidan-based nanocarriers to target the endothelial tumour vasculature and enhance blood-brain barrier crossing, achieving effective treatment of paediatric malignant brain tumours. The researchers also found that radiation treatment can increase the efficiency of this nanocarrier in penetrating the tumour microenvironment while minimizing toxicity to healthy brain tissue.

NATURE MATERIALS (2023)

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Article Nanoscience & Nanotechnology

Proximal tubules eliminate endocytosed gold nanoparticles through an organelle-extrusion-mediated self-renewal mechanism

Yingyu Huang et al.

Summary: The authors report a mechanism by which mitotically quiescent proximal tubular epithelial cells eliminate gold nanoparticles from the kidneys. This mechanism involves squeezing balloon-like extrusions through microvilli, transporting gold-containing endocytic vesicles along with organelles into the extrusions, and pinching the extrusions off the membranes into the lumen. This organelle-extrusion mechanism represents a new route for nanoparticle elimination.

NATURE NANOTECHNOLOGY (2023)

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Review Environmental Sciences

Green synthesis of ZnFe2O4 nanoparticles using plant extracts and their applications: A review

Ngoan Thi Thao Nguyen et al.

Summary: Biological methods are more preferred for synthesizing ZnFe2O4 nanoparticles with various applications. The effects of factors like Zn2+/Fe3+/extract ratio and calcination temperature on the properties of the nanoparticles were discussed. The photocatalytic activity and adsorption capabilities for removing toxic substances were evaluated, as well as the antibacterial, antifungal, and anticancer activities for biomedical applications. The limitations and prospects of green ZnFe2O4 as an alternative to traditional luminescent powders were proposed.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Article Cell Biology

Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple- negative breast cancer

Zhiwen Xu et al.

Summary: A fully humanized, high-affinity monoclonal antibody aNRP2-10 was developed in this study, which specifically inhibits the binding of VEGF to NRP2 on tumor cells, showing antitumor activity without toxicity. This antibody can be used for the treatment of triple-negative breast cancer by inhibiting cancer stem cell function and epithelial-to-mesenchymal transition, sensitizing tumor cells to chemotherapy and inhibiting metastasis.

SCIENCE TRANSLATIONAL MEDICINE (2023)

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Article Pharmacology & Pharmacy

Real-time SERS monitoring anticancer drug release along with SERS/MR imaging for pH- sensitive chemo-phototherapy

Xueqin Huang et al.

Summary: A novel pH-responsive nanosystem for real-time monitoring of drug release and chemo-phototherapy is proposed in this study. The nanosystem consists of Fe3O4@Au@Ag nanoparticles (NPs) deposited graphene oxide (GO) nanocomposites labeled with a Raman reporter and attached with a pH-responsive linker. The study demonstrates that the nanosystem can fulfill the synergistic combination of cancer cell targeting, pH-sensitive drug release, SERS-traceable detection, MR imaging, and photothermal therapy, showing great potential for efficient chemo-phototherapy on cancer treatment.

ACTA PHARMACEUTICA SINICA B (2023)

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Article Chemistry, Multidisciplinary

An Intelligent Vascular Disrupting Dendritic Nanodevice Incorporating Copper Sulfide Nanoparticles for Immune Modulation-Mediated Combination Tumor Therapy

Yiming Zhang et al.

Summary: Reported here is an intelligent dendritic nanodevice, called GLCD NPs, which incorporates copper sulfide nanoparticles (CuS NPs) and the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) within the dendrimer internal cavities and is surface modified with the targeting agent LyP-1 peptide. These functional GLCD NPs exhibit LyP-1-targeted killing effect on breast tumors by combining CuS-mediated photothermal therapy (PTT) and DMXAA-induced vascular disruption, while also triggering antitumor immune responses. In addition, the GLCD NPs can specifically kill tumor lymphatic endothelial cells, cutting off the two main pathways of tumor metastasis.

SMALL (2023)

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Article Chemistry, Multidisciplinary

DNA Damage Inducer Mitoxantrone Amplifies Synergistic Mild-Photothermal Chemotherapy for TNBC via Decreasing Heat Shock Protein 70 Expression

Zuqin Chen et al.

Summary: By integrating the clinically chemotherapeutic drug mitoxantrone (MTO) with a photothermal transduction agent, a multifunctional nanoplatform (MTO-micelles) is developed for mild-photothermal chemotherapy. This strategy enhances the binding of MTO to tumor cell DNA and weakens tumor thermoresistance, resulting in excellent synergetic tumor inhibition effects.

ADVANCED SCIENCE (2023)

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Article Oncology

Cancer statistics, 2023

Rebecca L. Siegel et al.

Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

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Review Oncology

Cell death, therapeutics, and the immune response in cancer

Kay Haenggi et al.

Summary: Cell death is closely associated with cancer treatment, but it can also trigger wound-healing processes related to cancer progression and treatment resistance. We describe the roles of apoptosis and lytic cell death pathways in therapy (including chemotherapy and immunotherapy). We discuss how necroptosis, pyroptosis, and ferroptosis promote tumor immunogenicity, but paradoxically contribute to immune suppression and tumor progression. Understanding the dual nature of cell death in cancer may lead to the development of therapeutics that induce regression.

TRENDS IN CANCER (2023)

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Article Chemistry, Multidisciplinary

Pt Decorated Ti3C2Tx MXene with NIR-II Light Amplified Nanozyme Catalytic Activity for Efficient Phototheranostics

Yanlin Zhu et al.

Summary: By using the two-dimensional ultrathin nano-sheet Ti3C2 as a substrate, Pt artificial nanozymes were decorated to synthesize Ti-based MXene nanocomposites Ti3C2Tx-Pt-PEG. In the tumor microenvironment, Pt nanoparticles exhibited peroxidase-like (POD-like) activity, generating hydroxyl radicals to induce cell apoptosis and necrosis. Meanwhile, the composite showed desirable photothermal effect under NIR-II light. Satisfactory synergistic therapy was achieved, accompanied by photoacoustic imaging capability.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Collective Plasmon Coupling in Gold Nanoparticle Clusters for Highly Efficient Photothermal Therapy

Jinxing Chen et al.

Summary: This study reports the development of plasmonic nanoparticle clusters (PNCs) as highly efficient photothermal therapy agents (PTAs) and provides a semi-quantitative calculation method for their resonant frequency and absorption efficiency. The optimized gold-based PNCs achieved a photothermal conversion efficiency of up to 84%. The study further demonstrates the extraordinary performance of the optimized PNCs in in vivo applications.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Biodegradable Polymer with Effective Near-Infrared-II Absorption as a Photothermal Agent for Deep Tumor Therapy

Yingjie Yu et al.

Summary: Photothermal therapy shows great potential for cancer treatment due to its effective tumor ablation and minimal invasiveness. This study introduces a new class of biodegradable photothermal agents that effectively absorb near-infrared light for deep tumor therapy, demonstrating successful results in a deep-seated ovarian cancer model. This work paves the way for the design of more effective photothermal agents.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Intelligent Gold Nanoparticles with Oncogenic MicroRNA-Dependent Activities to Manipulate Tumorigenic Environments for Synergistic Tumor Therapy

Xiangdong Wang et al.

Summary: This study utilizes spherical nucleic acids (SNAs) to effectively utilize and manipulate oncogenic microRNAs for tumor therapy. SNAs capture overexpressed miR-21/miR-155 and exert their effects through gene therapy and chemotherapy, while also achieving photothermal therapy and enhancing tumor treatment outcomes.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

A New Strategy for Microbial Taxonomic Identification through Micro-Biosynthetic Gold Nanoparticles and Machine Learning

Ting Yu et al.

Summary: Microorganisms can be used as biological factories to synthesize inorganic nanomaterials, and machine learning methods can be employed to classify and identify microorganisms at different levels based on the features of the biosynthesized nanomaterials. This strategy broadens the application of biosynthesis of inorganic materials and holds great promise for biomedical research.

ADVANCED MATERIALS (2022)

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Review Chemistry, Multidisciplinary

Application of Nanostructured TiO2 in UV Photodetectors: A Review

Ziliang Li et al.

Summary: Titanium dioxide (TiO2) as a wide-bandgap semiconductor material has gained significant attention for applications in fields like environmental and energy. Constructing high-performance photodetectors (PDs) based on TiO2 nanostructures with efficient microtopography and device configuration, while understanding key parameters influencing carrier behavior, is crucial for improved photoelectric performance and functional applications. This work provides an in-depth illustration of the electrical and optical properties of TiO2 nanostructures and advancements in technological issues for future applications.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Injectable hydrogel for postoperative synergistic photothermal-chemodynamic tumor and anti-infection therapy

Han Huang et al.

Summary: A light-activated injectable hydrogel has been developed to inhibit tumor growth, treat bacterial infection, and promote wound healing. Through photothermal and chemodynamic effects, the hydrogel can eliminate tumors and multidrug-resistant bacteria, as well as accelerate wound healing during treatment.

BIOMATERIALS (2022)

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Review Chemistry, Multidisciplinary

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Yishen Liu et al.

Summary: In vivo imaging in the second near-infrared window (NIR-II) has provided great opportunities for biomedical research and clinical applications. This review summarizes the design, properties, molecular imaging, and theranostics of inorganic/organic NIR-IIa/IIb fluorophores. The versatile applications and imaging modalities enabled by these advanced fluorescent properties are discussed, along with the challenges and perspectives for future clinical translation to boost the progress of NIR-IIa and NIR-IIb imaging technology.

CHEMICAL REVIEWS (2022)

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Review Chemistry, Multidisciplinary

Click and Bioorthogonal Chemistry: The Future of Active Targeting of Nanoparticles for Nanomedicines?

Ludivine Taiariol et al.

Summary: Click and bioorthogonal reactions are high-performance chemical reactions that have gained considerable attention in the biomedical field for the engineering of nanomedicines. This review compiles articles from 2014 to the present to highlight the application and main strategies of click chemistry and nanoparticles in biomedical applications.

CHEMICAL REVIEWS (2022)

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Article Oncology

Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants

Shuai Li et al.

Summary: This study aims to provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and BRCA2 for effective cancer risk management.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Review Oncology

Prospective Surveillance for Breast Cancer-Related Arm Lymphedema: A Systematic Review and Meta-Analysis

Bolette S. Rafn et al.

Summary: The study found that participation in prospective surveillance with early management can reduce the risk of chronic lymphedema in breast cancer patients. Only a small number of patients who are at high risk of lymphedema due to axillary surgery develop chronic lymphedema. More research is needed to determine whether prospective surveillance with early management can reduce the risk of chronic lymphedema, especially for cancer survivors other than breast cancer.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Chemistry, Multidisciplinary

Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists

Camilla Stavnsbjerg et al.

Summary: This study found that administration of TLR agonists in PEGylated liposomes can lead to the production of high levels of anti-PEG antibodies, which in turn cause accelerated blood clearance and acute hypersensitivity reactions. This highlights the importance of carefully designing nanoparticle delivery systems for immunotherapy to avoid anti-nanoparticle immune responses.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Nanoscience & Nanotechnology

Non-oxidized bare copper nanoparticles with surface excess electrons in air

Kyungwha Chung et al.

Summary: Non-oxidized bare copper nanoparticles can be maintained in air by passivating their surfaces with excess electrons. This finding has the potential to enhance the practical use of metal nanoparticles.

NATURE NANOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Silver Peroxide Nanoparticles for Combined Antibacterial Sonodynamic and Photothermal Therapy

Xuelong Bi et al.

Summary: Silver peroxide nanoparticles are capable of controlled release of reactive oxygen species under external stimuli of ultrasound and near-infrared light. They exhibit enhanced antibacterial and antibiofilm capabilities, accelerate wound closure and kill multi-drug resistant Staphylococcus aureus. Additionally, they show excellent cytocompatibility and hemocompatibility.

SMALL (2022)

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Article Oncology

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

Chewei Anderson Chang et al.

Summary: Resistance to targeted therapies in HER2-positive breast cancer is often attributed to the presence of drug-tolerant persisters (DTPs). This study reveals that HER2 TKI treatment leads to the emergence of DTPs with different transcriptomes, and these DTPs are originated from pre-DTP cells that cycle stochastically. The findings provide insights into the ontogeny of DTPs and potential vulnerabilities for therapeutic targeting.

CANCER DISCOVERY (2022)

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Review Medicine, Research & Experimental

Targeting regulated cell death in tumor nanomedicines

Qinghu Zeng et al.

Summary: Nanomedicines have great potential in anticancer therapy, but they are limited by self-protection mechanisms and treatment resistance of cancer cells. Recent studies have shown that regulating cell death can enhance the therapeutic efficiency of tumors. This article introduces various strategies of regulated cell death-mediated synergistic tumor nanotherapeutics and discusses the coordination mechanisms.

THERANOSTICS (2022)

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Article Engineering, Biomedical

Near-Infrared Light Triggered H2 Generation for Enhanced Photothermal/Photodynamic Therapy against Hypoxic Tumor

Haoying Ge et al.

Summary: The study introduces a novel nanostructure, l-TiO2-GNR, which effectively treats hypoxic tumors by combining type I-PDT, mild PTT, and H-2 therapy. This structure helps reduce stress responses in tumor cells, providing a new approach for treating hypoxic tumors.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

γ-Fe2O3 Loading Mitoxantrone and Glucose Oxidase for pH-Responsive Chemo/Chemodynamic/Photothermal Synergistic Cancer Therapy

Zhihao Zhong et al.

Summary: This study presents a new therapeutic nanoplatform for synergistic cancer therapy using photoacoustic imaging-guided chemo/chemodynamic/photothermal (CT/CDT/PTT) approaches. The synthesized nanoplatform showed selective accumulation at tumor sites and demonstrated significant synergistic therapeutic effects in vitro and in vivo.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Pharmacology & Pharmacy

Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy

Xianbin Ma et al.

Summary: The combination of chemotherapy and immunotherapy shows great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment. However, drug bioavailability limits the therapeutic effectiveness. In this study, a bioresponsive doxorubicin-based nanogel was developed for tumor-specific co-delivery of drugs. The nanogel exhibited stability, selective drug release, and prolonged survival time. It induced powerful antitumor immune response and damaged glucose metabolism in glycolysis and the tricarboxylic acid cycle. This nanogel provides a potential strategy to overcome the limitations of immunotherapy and offers a paradigm for immunomodulatory nanomedicines.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Multidisciplinary Sciences

Computational analysis of drug free silver triangular nanoprism theranostic probe plasmonic behavior for in-situ tumor imaging and photothermal therapy

Sudip Mondal et al.

Summary: This study introduces an innovative computationally-driven approach to quantify the photothermal efficiency of plasmonic nanoparticles before their therapeutic use. The development of drug-free plasmonic silver triangular nanoprisms for photoacoustic imaging (PAI) guided photothermal treatment (PTT) in triple-negative breast cancer mouse models is presented.

JOURNAL OF ADVANCED RESEARCH (2022)

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Article Engineering, Biomedical

Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria

Wenguang Wang et al.

Summary: Flagellated bacteria coated with antigen-adsorbing polymer nanoparticles and injected into tumours in mice after radiotherapy elicit systemic antitumour effects by transporting antigens to the tumour's periphery. This finding highlights the potential of leveraging bacteria to enhance dendritic cell activation and improve in situ cancer vaccination strategies.

NATURE BIOMEDICAL ENGINEERING (2022)

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Article Nanoscience & Nanotechnology

Si/TiO2/Ag Multistorey Structures with Interfacial Charge Transfer for a Recyclable Surface-Enhanced Raman Scattering Substrate

Jieyi Cai et al.

Summary: Highly ordered TiO2/Ag bilayer structures were fabricated on p-type silicon wafers using photolithography and electrochemical self-assembly methods. The interfacial charge transfer behavior of the Si/TiO2/Ag structure was studied, which is crucial for enhancing SERS performance.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Biomedical

Copper-based theranostic nanocatalysts for synergetic photothermal-chemodynamic therapy

Wenbao Zuo et al.

Summary: This study developed a CAI-functionalized Cu-based nanocatalyst for MRI/PA-guided PTT and CDT, which can self-cyclically amplify CDT while enhancing treatment efficacy through photothermal therapy.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Multidisciplinary

Semiconducting Polymer Nanoparticles with Intramolecular Motion-Induced Photothermy for Tumor Phototheranostics and Tooth Root Canal Therapy

Xingchen Duan et al.

Summary: A novel photoacoustic/photothermal nanoparticle with strong near-infrared absorption, good biocompatibility, and high photothermal conversion efficiency was developed. The nanoparticle shows great potential for improved disease diagnosis and treatment.

ADVANCED MATERIALS (2022)

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Review Chemistry, Multidisciplinary

Thermoplasmonics in Solar Energy Conversion: Materials, Nanostructured Designs, and Applications

Bei Yang et al.

Summary: Thermoplasmonics is an promising solution for solar energy conversion, offering enhanced light absorption and scattering, hot carrier generation, and localized/collective heating effects for optimized energy conversion. Material selection and nanostructure design are crucial for achieving higher efficiency. Thermoplasmonics has applications in solar evaporation, photothermal chemistry, and thermophotovoltaic systems.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Rapid Surface Display of mRNA Antigens by Bacteria-Derived Outer Membrane Vesicles for a Personalized Tumor Vaccine

Yao Li et al.

Summary: This study utilized bacteria-derived outer membrane vesicles (OMVs) as a delivery platform for mRNA, genetically modified to deliver specific mRNA antigens into dendritic cells, triggering anti-tumor immune responses. The results showed that this platform significantly inhibited tumor progression and achieved 37.5% complete regression in an in vivo model.

ADVANCED MATERIALS (2022)

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Article Engineering, Biomedical

Branched PEG-modification: A new strategy for nanocarriers to evade of the accelerated blood clearance phenomenon and enhance anti-tumor efficacy

Min Liu et al.

Summary: This study investigated the impact of branched PEG modification on nanocarriers and found that it has lower antigenicity and better anti-tumor efficacy compared to linear PEG modification.

BIOMATERIALS (2022)

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Article Oncology

Redefining breast cancer subtypes to guide treatment prioritization and maximize response: Predictive biomarkers across 10 cancer therapies

Denise M. Wolf et al.

Summary: By incorporating gene expression, protein/phosphoprotein, and clinical data, we have created new breast cancer subtypes that can better predict drug responses. The best performing subtypes include Immune, DNA repair, and HER2/Luminal phenotypes. Treatment allocation based on these subtypes significantly increases the overall pathologic complete response rate. This study is important for guiding future breast cancer treatment.

CANCER CELL (2022)

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Review Chemistry, Multidisciplinary

Molecular Cavity for Catalysis and Formation of Metal Nanoparticles for Use in Catalysis

Rupak Saha et al.

Summary: The employment of weak intermolecular interactions in supramolecular chemistry provides an alternative approach to create artificial chemical environments resembling the active sites of enzymes. In recent years, discrete molecular architectures with defined shapes and geometries have revolutionized the field due to their intrinsic porosity and ease of synthesis using dynamic non-covalent/covalent interactions. These supramolecular systems have demonstrated various applications and catalysis within confined nanospaces has shown significant growth. This review highlights the recent advancements in catalytic activity influenced by the nanocavities of hydrogen-bonded cages, metal-ligand coordination cages, and dynamic or reversible covalently bonded organic cages in different solvent media.

CHEMICAL REVIEWS (2022)

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Article Oncology

Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer: ASCO Guideline Update

Fabrice Andre et al.

Summary: This article provides updated recommendations on the appropriate use of breast cancer biomarker assay results in guiding adjuvant endocrine and chemotherapy decisions for early-stage breast cancer. Based on the latest literature and expert consensus, specific biomarker assay results can be used to guide treatment decisions for patients who meet certain criteria. However, other factors such as disease stage, comorbidities, and patient preferences should also be considered.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Medicine, Research & Experimental

Photothermal therapy-mediated autophagy in breast cancer treatment: Progress and trends

Jamileh Kadkhoda et al.

Summary: This review provides insights into the potential mechanisms of photothermal therapy in breast cancer treatment, particularly through regulating autophagy to induce cell death.

LIFE SCIENCES (2022)

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Article Oncology

Heat shock proteins and exosomes in cancer theranostics

Mathilde Regimbeau et al.

Summary: Heat shock proteins (HSPs) are a superfamily of molecular chaperones that play important roles in protein homeostasis, cell proliferation, differentiation, and inhibiting cell death. In cancer cells, HSPs are highly abundant and have been found to be involved in processes such as apoptosis regulation, immune responses, angiogenesis, metastasis, and treatment resistance. Additionally, cancer cells can secrete HSPs through exosomes, which can serve as biomarkers for cancer dissemination, therapy response, and patient outcome. These extracellular HSPs also have emerging functions in modulating anticancer immune responses. This review focuses on describing the recently reported functions of HSP-exosomes as therapeutic targets and disease biomarkers in cancer, as well as their potential in cancer vaccines.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Chemistry, Multidisciplinary

A Top-Down Templating Strategy toward Functional Porous Carbons

Le-Le Zhang et al.

Summary: This paper presents a top-down templating strategy for the synthesis of functional porous carbon materials with high porosity and desired chemical functionalities. The porosity and heteroatom doping of the carbon materials can be controlled by varying the organic precursors and metal oxides. The strategy is also applicable for the preparation of carbon-based single-atom catalysts with iron-nitrogen sites.

SMALL (2022)

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Article Chemistry, Multidisciplinary

Nanohelix-Induced Optical Activity of Liquid Metal Nanoparticles

Lin Yang et al.

Summary: This study immobilizes liquid metal Ga nanoparticles on the surface of SiO2 nanohelices, forming chirality structures with chiroplasmonic optical activity. The chiroplasmonic optical activity shows high environmental stability and is stabilized by spontaneous oxidation of the Ga nanoparticles.

SMALL (2022)

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Article Multidisciplinary Sciences

Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts

Xin Li et al.

Summary: The study demonstrates that co-delivery of indocyanine green and calcipotriol using tumor cell-derived microparticles can enhance the efficacy of photothermal therapy by remodeling the tumor extracellular matrix and improving anti-tumor immune responses.

NATURE COMMUNICATIONS (2022)

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Review Chemistry, Multidisciplinary

Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Zhilin Li et al.

Summary: This article reviews the use of nanostructure-based drug delivery systems (NDDSs) to enhance the effectiveness of tumor immunotherapy. By inducing immunogenic cell death (ICD) and releasing danger-associated molecular patterns (DAMPs) and tumor-associated antigens, in combination with chemotherapy, photodynamic therapy, photothermal therapy, and radiotherapy, the tumor immunosuppressive microenvironment can be improved, resulting in increased sensitivity to immunotherapy and reduced side effects.

ADVANCED SCIENCE (2022)

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Review Chemistry, Multidisciplinary

Engineered upconversion nanocarriers for synergistic breast cancer imaging and therapy: Current state of art

Pavan Kumar Chintamaneni et al.

Summary: Breast cancer is the most common type of cancer in women, and early diagnosis and effective therapeutic interventions are crucial for improving survival and quality of life. Nanotheranostics, specifically rare earth metal-doped upconversion nanoparticles (UCNPs), show promise in providing both in vivo diagnosis and therapeutics in breast cancer treatment.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Pushing the Boundaries of Multicomponent Alloy Nanostructures: Hybrid Approach of Liquid Phase Separation and Selective Leaching Processes

Jinwoo Kim et al.

Summary: Alloying, the mixing of multiple metallic elements, has been a classic method for novel materials development since ancient times. This article describes a hybrid approach combining metallurgical bottom-up and chemical top-down processes for fabricating multicomponent alloy nanostructures. The method allows for precise control of alloy composition and cooling rate to prepare precursor alloys for nanoparticles and nanofoams with varied atomic structures and sizes.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Determination of the nanoparticle- and cell-specific toxicological mechanisms in 3D liver spheroids using scRNAseq analysis

Jiulong Li et al.

Nano Today (2022)

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Article Chemistry, Multidisciplinary

Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple-Negative Breast Cancer

Zitong Zhao et al.

Summary: In this study, walking dead TNBC cells were developed by conjugating anti-PD-1 and doxorubicin-loaded liposomes onto cell corpses for temporal chemo-immunotherapy against lung metastasis. The walking dead TNBC cells improved drug accumulation and local retention in the lungs, reprogrammed the lung microenvironment, and prolonged overall survival in mice with lung metastasis.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Direct Dry Synthesis of Supported Bimetallic Catalysts: A Study on Comminution and Alloying of Metal Nanoparticles

Jacopo De Bellis et al.

Summary: Ball milling is a valuable method for preparing catalytic materials, as it allows for the direct synthesis of supported metal catalysts and the formation of bimetallic nanoparticles. A systematic investigation into different metals and supports has provided insights into the mechanisms of comminution and alloying of metal nanoparticles. These findings will contribute to the rational design of supported metal catalysts via dry ball milling.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Engineering, Biomedical

Dual drugs decorated bacteria irradiate deep hypoxic tumor and arouse strong immune responses

Wenfei Chen et al.

Summary: This study demonstrates the successful use of engineered Salmonella bacteria with modified surface to achieve targeted photothermal therapy and magnified immunotherapy in tumor tissues. The synergistic strategy stimulates the immune system from multiple dimensions, leading to effective prevention and inhibition of tumor growth.

BIOMATERIALS (2022)

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Review Multidisciplinary Sciences

Engineering bacteria as interactive cancer therapies

Candice R. Gurbatri et al.

Summary: With the use of synthetic biology tools, researchers are repurposing bacteria as tumor-specific delivery systems, which can modulate the tumor microenvironment and enhance therapeutic efficacy and safety through their immunogenicity and local payload production.

SCIENCE (2022)

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Article Multidisciplinary Sciences

A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging

Hongwei Lu et al.

Summary: In this study, a MRI contrast agent with optimized contrast sensitivity was synthesized and successfully applied to trace liver metastases and monitor tissue inflammation.

NATURE COMMUNICATIONS (2022)

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Review Chemistry, Multidisciplinary

Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer

Ujala Gupta et al.

Summary: Breast cancer is the most common malignancy in women worldwide, and current therapies have limited effectiveness for advanced and metastatic breast cancers. Nanotechnology, particularly lipid-based nanoplatforms, has emerged as a promising approach for breast cancer treatment due to their controlled drug release, reduced toxicity, and improved drug encapsulation efficiency. This review summarizes the applications of lipid-engineered nanotechnological tools in breast cancer treatment and discusses the use of various therapeutic agents, including chemotherapeutics, phytomedicine, genes, peptides, photosensitizers, and immunogenic agents. It provides detailed information on the physicochemical properties of lipidic nanocarriers, in vitro and in vivo studies, and clinical trials. Overall, the review highlights the potential of lipidic nanoplatforms as a promising strategy for cancer nanotherapeutics.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Biomimetic nanoparticles for effective mild temperature photothermal therapy and multimodal imaging

Xian Shu et al.

Summary: By downregulating ATP-dependent heat shock proteins, the designed nanoparticles achieved high-efficiency mild temperature photothermal therapy, which is promising for future clinical translational studies.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Vascular bursts-mediated tumor accumulation and deep penetration of spherical nucleic acids for synergistic radio-immunotherapy

Jiahao Liu et al.

Summary: A two-step low-dose radiotherapy strategy combined with spherical nucleic acids-based nanomedicine was used to enhance the accumulation and penetration of nanoparticles in tumors. The strategy successfully recruited macrophages into the tumor, which not only served as drug depots but also enhanced extravasation to improve nanoparticle accumulation. Through optimized timing and administration, the delivered nanoparticles promoted a phenotype switch in macrophages, resulting in increased phagocytosis and further enhancing accumulation and penetration. This approach showed significant enhancement of nanoparticles accumulation compared to passive targeting, with efficient deep penetration throughout the tumor tissue.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Engineering, Environmental

Self-assembled NIR-responsive MoS2@quaternized chitosan/nanocellulose composite paper for recyclable antibacteria

Bichong Luo et al.

Summary: This study introduces NIR-responsive molybdenum disulfide nanosheets (MoS2) to confer antibacterial activity to nanocellulose paper. The MoS2 nanosheets are combined with quaternized chitosan to create a composite paper with excellent photothermal and photodynamic activity, leading to highly efficient antibacterial efficacy.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Medicine, General & Internal

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study

Boon H Chua et al.

LANCET (2022)

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Review Cell Biology

Targeting TRAIL Death Receptors in Triple-Negative Breast Cancers: Challenges and Strategies for Cancer Therapy

Manjari Kundu et al.

Summary: This review discusses the signaling components and mechanisms of the TRAIL pathway, as well as the challenges and potential solutions for TRAIL/DR targeted therapy in TNBC clinical trials. The article also explores the pharmacokinetic and pharmacodynamic properties of DR agonists, patient selection through predictive biomarkers, and potential combination therapies. Additionally, recent findings on the impact of TRAIL treatment on the immune response and novel strategies to address these challenges are discussed.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Indocyanine green as a near-infrared theranostic agent for ferroptosis and apoptosis-based, photothermal, and photodynamic cancer therapy

Hsiang-Ching Tseng et al.

Summary: This study investigated whether the combination of indocyanine green (ICG) and near-infrared (NIR) irradiation can induce ferroptosis and explored the potential of using ICG-NIR irradiation for cancer treatment. The results showed that ICG combined with 808-nm laser irradiation could induce apoptosis and ferroptosis in cancer cells, and had significant inhibitory effects on cancer.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Engineering, Biomedical

A Cancer Cell Membrane-Derived Biomimetic Nanocarrier for Synergistic Photothermal/Gene Therapy by Efficient Delivery of CRISPR/Cas9 and Gold Nanorods

Lin Huang et al.

Summary: A cancer cell membrane-derived nanocarrier was developed for synergistic photothermal/gene therapy. This nanotherapeutic platform showed high biocompatibility, homologous targeting capacity, and efficient payload delivery, leading to enhanced therapeutic efficacy.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Pharmacology & Pharmacy

Tumor-microenvironment activated duplex genome-editing nanoprodrug for sensitized near-infrared titania phototherapy

Zekun Li et al.

Summary: NIR-light-triggered nanomedicine, including PDT and PTT, is an attractive approach for cancer therapy due to its controllability and minimal invasion. A tumor-microenvironment responsive CRISPR nanoplatform based on oxygen-deficient titania has been developed for mild NIR-phototherapy. In the tumor microenvironment, the overexpressed HAase and GSH can destroy HA and disulfide bond, releasing Cas9/sgRNA to target stress alleviating regulators and reduce stress tolerance of tumor cells. Under NIR light, the TiO2 exhibits a higher anticancer effect.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Engineering, Biomedical

Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis

Guorong Zhang et al.

Summary: Encapsulating antibiotics in orally administered positively charged polymeric nanoparticles with a glucosylated surface improves absorption in the proximal small intestine and limits exposure to flora in the large intestine.

NATURE BIOMEDICAL ENGINEERING (2022)

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Review Chemistry, Multidisciplinary

From Low to No O2-Dependent Hypoxia Photodynamic Therapy (hPDT): A New Perspective

Mingle Li et al.

Summary: Photodynamic therapy (PDT) is a photon-initiated treatment modality that uses reactive oxygen species (ROS) to kill malignant cells. However, tumor hypoxia poses a challenge to the effectiveness of PDT. Various strategies have been explored to improve intratumoral oxygenation, but they also face challenges. This article presents recent research on combating hypoxia-induced resistance in PDT under low to no oxygen conditions and discusses the concepts, molecular designs, photochemical mechanisms, and applications in cancer diagnosis and therapeutics.

ACCOUNTS OF CHEMICAL RESEARCH (2022)

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Article Materials Science, Multidisciplinary

A Two-Pronged Strategy for Enhanced Deep-Tumor Penetration and NIR-II Multimodal Imaging-Monitored Photothermal Therapy

Shuting Li et al.

ACS Applied Materials & Interfaces (2022)

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Article Nanoscience & Nanotechnology

Combined Chemo-Immuno-Photothermal Therapy for Effective Cancer Treatment via an All-in-One and One-for-All Nanoplatform

Xianglong Yu et al.

Summary: This study established a multifunctional nanoplatform for combined chemo-immuno-photothermal therapy to improve the anti-tumor efficacy. The nanoplatform showed excellent biological activity and could effectively inhibit tumor cell migration and metastasis. In addition, it promoted immune cell activation and infiltration to clear residual tumor cells.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Chemistry, Multidisciplinary

Directed Assembly of Nanomaterials for Making Nanoscale Devices and Structures: Mechanisms and Applications

Zhimin Chai et al.

Summary: Nanofabrication based on directed assembly, utilizing external fields to interact with nanoelements and assemble functional structures, is attracting more interest recently due to its low cost and additive manufacturing advantages. The external fields used in directed assembly include electric, fluidic flow, magnetic, and optical fields.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Cu Single Atom Nanozyme Based High-Efficiency Mild Photothermal Therapy through Cellular Metabolic Regulation

Mengyu Chang et al.

Summary: In this study, a polyporous Cu single atom nanozyme loaded with licogliflozin (LIK066) was designed to achieve efficient mild photothermal therapy (PTT) by inhibiting heat shock proteins (HSPs) synthesis and damaging existing HSPs in cancer cells.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Engineering, Biomedical

Multifunctional light-activatable nanocomplex conducting temperate-heat photothermal therapy to avert excessive inflammation and trigger augmented immunotherapy

Lu Li et al.

Summary: This study reports a multifunctional light-activatable nanocomplex that avoids hyperthermia and achieves temperate-heat photothermal therapy (PTT) to induce extensive apoptosis, enhance anti-tumor immune response, and inhibit tumor metastasis and recurrence. The nanocomplex maintains a specific temperature upon near-infrared irradiation, allowing controlled drug release to disrupt the thermoresistance of tumor cells. Additionally, it promotes tumor perfusion of dendritic cells (DCs) and T lymphocytes, alleviates the immunosuppressive microenvironment, and elicits a strong systemic immune response.

BIOMATERIALS (2022)

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Review Chemistry, Multidisciplinary

Recent advances in nanoparticle-based photothermal therapy for breast cancer

Sania Ghobadi Alamdari et al.

Summary: Nanotechnology plays an important role in photothermal therapy of breast cancer, enhancing the effectiveness by utilizing the characteristics of nanoparticles and combining with other treatment methods. Targeted therapy can be achieved by incorporating specific ligands on nanoparticles.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Nanoscience & Nanotechnology

Remotely controlled near-infrared-triggered photothermal treatment of brain tumours in freely behaving mice using gold nanostars

Hamed Arami et al.

Summary: In this study, a wireless near-infrared stimulation-based photothermal approach for the continuous and on-demand treatment of brain tumours in freely moving animals is presented. The method avoids the risks and side-effects associated with open-skull tumour resection and chemotherapy or X-ray radiation. It utilizes an integrated nanomedicine-bioelectronics brain-machine interface, allowing precise treatment of deep brain tumours and selective diffusion of treatment in tumour tissues.

NATURE NANOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

A Precipitation-Enhanced Emission (PEE) Strategy for Increasing the Brightness and Reducing the Liver Retention of NIR-II Fluorophores

Jinwei Li et al.

Summary: A method is proposed to address the lack of organic fluorophores with high quantum yields and low liver retention in the NIR-II window by encapsulating phosphorylated fluorescent dyes into biodegradable calcium phosphate nanoparticles. By co-precipitation, the quantum yields of the fluorescent dyes in aqueous solution are significantly increased through a phenomenon called "precipitation-enhanced emission". The co-precipitation also changes the micro-environment and improves the metabolism of the nanoparticles in the liver, enabling high-contrast vascular visualization and breast tumor detection.

SMALL (2022)

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Article Multidisciplinary Sciences

Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer-a preclinical study

Guannan Wang et al.

Summary: The study demonstrated potent antitumor effects of intraductal injection of HB21(Fv)-PE40 on breast cancer, providing a strong preclinical foundation for conducting feasibility and safety trials in breast cancer patients.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Review Chemistry, Multidisciplinary

Unravelling the benefits of transition-metal-co-doping in lanthanide upconversion nanoparticles

Sonali Mohanty et al.

Summary: Recent advances in upconversion luminescent materials have highlighted their importance in both scientific research and future applications. However, the low upconversion luminescence intensity and limited tuneability hinder their versatile applications. This tutorial review focuses on the implementation of transition metal ion co-dopants to enhance upconversion efficiency in lanthanide nanomaterials. The review summarizes recent studies on the tailored design of UC materials with transition metal ion co-dopants and discusses the desirable functionality of transition metal ions in the host matrixes. In addition to improving upconversion efficiency, the incorporation of transition metal co-dopants has sparked interest in applications such as in vivo imaging, drug delivery, and nanothermometers.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Oncology

Necroptosis and tumor progression

Jiong Yan et al.

Summary: Necroptosis, a form of programmed necrotic cell death, plays a crucial role in host defense and inflammatory diseases, and has emerged as an important factor in tumorigenesis and metastasis, suggesting its potential as a novel cancer therapy target.

TRENDS IN CANCER (2022)

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Article Oncology

PD-L1 status in breast cancer: Current view and perspectives

Semir Vranic et al.

Summary: Breast cancer, traditionally considered not highly immunogenic, has been found to exhibit immunogenicity in some cases, particularly in aggressive triple-negative types. However, challenges remain in identifying patients who would benefit from immunotherapy and in analyzing samples accurately for immune cell targets. Explore exploration of checkpoint inhibitors in breast cancer, specifically in PD-L1 testing, is an important aspect of current research.

SEMINARS IN CANCER BIOLOGY (2021)

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Review Chemistry, Multidisciplinary

Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging: Fundamentals, Challenges, Applications, and Prospectives

Mike Jeon et al.

Summary: Gadolinium-based chelates are commonly used contrast agents for MRI, but their toxicity and potential retention in patients' bodies have raised safety concerns. Iron oxide nanoparticles have emerged as a promising alternative due to their non-toxic and biodegradable nature, but their development as T-1 contrast agents is complex and challenging. Progress is being made in exploring IONPs as safe and improved alternatives, but there are still many hurdles to overcome before they can be used clinically.

ADVANCED MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Encapsulated Metal Nanoparticles for Catalysis

Chuanbo Gao et al.

Summary: Encapsulating metal nanoparticles in nanoshells or nanopores is a promising strategy to enhance stability and selectivity, taking advantage of the synergy between the metal nanoparticles and encapsulating materials. This approach also allows for improved catalytic properties and enables tandem catalysis in various applications.

CHEMICAL REVIEWS (2021)

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Article Engineering, Environmental

Recoverable peroxidase-like Fe3O4@MoS2-Ag nanozyme with enhanced antibacterial ability

Feng Wei et al.

Summary: The study successfully demonstrated the efficient antibacterial performance of Fe3O4@MoS2-Ag nanozyme against E. coli, and revealed a synergistic disinfection effect. Through the collaborative work of peroxidase-like activity, photothermal effect, and Ag+ leakage, the nanozyme could accurately and rapidly attack bacterial membranes, showing broad-spectrum antibacterial capabilities.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Chemistry, Multidisciplinary

A Facile Strategy of Boosting Photothermal Conversion Efficiency through State Transformation for Cancer Therapy

Jie Li et al.

Summary: This study presents a new strategy to increase photothermal conversion efficiency by transforming photothermal agents from aggregated state to dispersed state, improving the therapeutic performance of photothermal therapy. By releasing photothermal molecules from nanoparticles to achieve state transformation, a distinct photothermal therapeutic performance for cancer ablation can be demonstrated in lysosome of cancer cells.

ADVANCED MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Voltage-Switchable Biosensor with Gold Nanoparticles on TiO2 Nanotubes Decorated with CdS Quantum Dots for the Detection of Cholesterol and H2O2

Nilem Khaliq et al.

Summary: A hybrid nanostructure electrode based on Au/CdS QDs/TNTs was fabricated for nonenzymatic detection of cholesterol and hydrogen peroxide, showing enhanced sensitivity and selectivity. The biosensor demonstrated good reproducibility and thermal stability, with promising potential for enzyme-free biosensing applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Super Bright Red Upconversion in NaErF4:0.5%Tm@NaYF4:20%Yb Nanoparticles for Anti-counterfeit and Bioimaging Applications

Rashmi Joshi et al.

Summary: This work presents the preparation of a super bright red emitter at 655 nm from monodispersed nanocrystals by utilizing an Er3+-enriched host matrix as both an activator and sensitizer. Incorporation of Tm3+ and Yb3+ ions in the core and shell structure enhances the red emission efficiency and reduces luminescence quenching.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy

Mengyu Chang et al.

Summary: Hyperthermia therapy has emerged as a strategy against malignant tumors, particularly when combined with nanomaterial-based photothermal therapy or magnetic hyperthermia. While these treatments alone may not completely cure cancer, when combined with cancer immunotherapy, they have shown potential for enhanced therapeutic outcomes against both primary tumors and metastatic lesions, as well as preventing cancer recurrence and prolonging survival period.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Second Near-Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy

Jingchao Li et al.

Summary: This study introduces a novel semiconducting polymer nanoadjuvant for second NIR-II photothermal immunotherapy, which effectively inhibits tumor growth and eliminates metastasis through a combination of photothermal conversion and TLR agonist release.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Activatable NIR-II Plasmonic Nanotheranostics for Efficient Photoacoustic Imaging and Photothermal Cancer Therapy

Chunyu Zhou et al.

Summary: The study presents a transformable chain structure based on gold nanochains that can be activated in the tumor microenvironment, exhibiting strong NIR-II absorption and excellent properties for tumor treatment.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Nanoparticle-Mediated Delivery of Inhaled Immunotherapeutics for Treating Lung Metastasis

Qiutong Jin et al.

Summary: This study developed an inhaled immunotherapeutic chitosan-antibody complex that effectively activates the immune system, promotes infiltration of different immune cells around tumor lesions, and prolongs the survival of mice.

ADVANCED MATERIALS (2021)

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Review Oncology

Immunotherapy for early breast cancer: too soon, too superficial, or just right?

M. A. Franzoi et al.

Summary: As immunotherapy becomes a new treatment modality for breast cancer, there is increasing interest in combinatorial therapies, especially in the early disease setting. Despite the plethora of ongoing immunotherapy trials in early breast cancer, solid data in advanced disease are still lacking. This review looks at efforts to establish the efficacy and safety of immunotherapeutic agents in early breast cancer.

ANNALS OF ONCOLOGY (2021)

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Article Engineering, Biomedical

Multistage-responsive clustered nanosystem to improve tumor accumulation and penetration for photothermal/enhanced radiation synergistic therapy

Shiyuan Hua et al.

Summary: Developing responsive nanosystems to overcome tumor biological barriers is key to achieving effective and promising therapeutic outcomes. The multistage responsive clustered nanosystem designed in this study shows great potential in tumor therapy by effectively accumulating and penetrating tumors.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Enhanced immune memory through a constant photothermal-metabolism regulation for cancer prevention and treatment

Lihua Luo et al.

Summary: Effective tumor vaccine is crucial in boosting immune system to produce more memory T cells, which has great potential for cancer prevention and therapy.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Ag2S nanoparticle-mediated multiple ablations reinvigorates the immune response for enhanced cancer photo-immunotherapy

Ruxia Han et al.

Summary: Photothermal therapy (PTT) using water-soluble Ag2S nanoparticles (NPs) has shown promising results in cancer treatment. Studies have found that multiple PTT cycles with Ag2S NPs can inhibit primary tumor cell proliferation, reduce tumor recurrence, and alleviate metastasis by stimulating the immune response in a mouse breast cancer model.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Photo-activated chemo-immunotherapy for metastatic cancer using a synergistic graphene nanosystem

Feifan Zhou et al.

Summary: By combining photothermal therapy, chemotherapy, and immunotherapy through a nanosystem, researchers developed a treatment strategy that not only destroyed local tumors and inhibited distant metastases in mouse models but also induced long-term survivors with tumor type-specific immunity. This synergistic approach showed potential for treating metastatic cancers by inducing a systemic antitumor response through a local intervention.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Intelligent MoS2-CuO heterostructures with multiplexed imaging and remarkably enhanced antitumor efficacy via synergetic photothermal therapy/ chemodynamic therapy/ immunotherapy

Fan Jiang et al.

Summary: The MoS2-CuO nanoplatform designed in this study integrates multimodal imaging and therapeutic functions for cancer treatment. It is capable of enhancing antitumor efficacy through a combination of photothermal therapy, chemodynamic therapy, and immunotherapy, while also generating strong antitumor immune responses for effectively eliminating primary and metastatic tumors.

BIOMATERIALS (2021)

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Article Engineering, Biomedical

Synergistic photothermal cancer immunotherapy by Cas9 ribonucleoprotein-based copper sulfide nanotherapeutic platform targeting PTPN2

Tao Yan et al.

Summary: This study introduces a multifunctional nanotherapeutic system utilizing copper sulfide (CuS) nanomaterial for combined photothermal therapy (PTT) and immunotherapy on melanoma. The system effectively depletes PTPN2, boosts intratumoral CD8 T lymphocytes, and enhances the response to immunotherapy. These synergistic effects, along with tumor ablation and immunogenic cell death induced by PTT, provide a promising treatment option for advanced malignant neoplasm.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Mukaddes Izci et al.

Summary: Research has shown that despite efforts to utilize the EPR effect for enhanced delivery of nanomaterials to solid tumors, the results are still poor. Furthermore, some studies question the role of the EPR effect, suggesting that nanomaterials may enter tumors through active mechanisms rather than through endothelial gaps.

CHEMICAL REVIEWS (2021)

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Article Pharmacology & Pharmacy

Vascular disrupting agents in cancer therapy

Ryszard Smolarczyk et al.

Summary: Tumor blood vessel formation is crucial for tumor expansion, and targeting tumor vessels specifically can be an effective anti-cancer treatment method.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Chemistry, Multidisciplinary

Magnetic Nanoparticles: Synthesis, Anisotropy, and Applications

Zhenhui Ma et al.

Summary: The review discusses the effects of anisotropy on magnetic nanoparticles and their potential applications in various fields.

CHEMICAL REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Gold Nanorods: The Most Versatile Plasmonic Nanoparticles

Jiapeng Zheng et al.

Summary: Gold nanorods are a versatile material with anisotropic shape and adjustable plasmonic properties, which have been widely used in various fields. Continuous improvement in synthetic methods enables diverse applications of Au NRs and exploration of cutting-edge technologies. The future research directions and challenges will focus on further improving synthetic methods to expand the application scope of Au NRs.

CHEMICAL REVIEWS (2021)

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Article Oncology

Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group

Torsten O. Nielsen et al.

Summary: Ki67 immunohistochemistry (IHC) is commonly used in breast cancer as a proliferation marker, but its analytical validity has been questioned. The International Ki67 in Breast Cancer Working Group (IKWG) recommends careful preanalytical handling, adoption of a standardized visual scoring method, and participation in quality assurance and quality control programs. Clinical utility of Ki67 IHC in breast cancer care is currently limited to prognosis assessment in stage I or II breast cancer.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

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Article Immunology

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Nicole E. Scharping et al.

Summary: Continuous TCR signaling and hypoxia increase Blimp-1, suppressing mitochondrial reprogramming and generating reactive oxygen species, leading to T cell exhaustion. Mitigating T cell-intrinsic ROS and reducing tumor hypoxia can limit T cell exhaustion, synergizing with immunotherapy.

NATURE IMMUNOLOGY (2021)

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Review Chemistry, Multidisciplinary

Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near-Infrared Construction

Xu Zhen et al.

Summary: The development of semiconducting polymer nanoparticles (SPNs) for photoacoustic imaging and photothermal therapy has shown promising results due to their clear structure-property relation and molecular structural tunability. Various strategies such as structure-property screening, fluorescence quenching, accelerated heat dissipation, and size-dependent heat dissipation have been discussed to amplify the PA brightness of SPNs for in vivo PA. Additionally, molecular approaches have been introduced to shift the absorption of SPNs for NIR-II PA imaging and PTT in order to improve tissue penetration depth for diagnosis and therapy.

SMALL (2021)

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Review Chemistry, Physical

Surgical Navigation for Malignancies Guided by Near-Infrared-II Fluorescence Imaging

Rui-Qin Yang et al.

Summary: NIR-II fluorescence imaging has shown unique advantages in guiding tumor resection surgery, with improved penetration depths and signal-to-noise ratios. Its application in cancer surgery has demonstrated significant prospects for improving surgical outcomes.

SMALL METHODS (2021)

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Article Chemistry, Multidisciplinary

Tumor-Selective Immune-Active Mild Hyperthermia Associated with Chemotherapy in Colon Peritoneal Metastasis by Photoactivation of Fluorouracil-Gold Nanoparticle Complexes

Vladimir Mulens-Arias et al.

Summary: A strategy using near-infrared photoactivated gold nanoparticles coupled with chemotherapy drug was proposed to achieve precise treatment of tumor nodules within the peritoneal cavity, providing potential to overcome the off-target toxicity and high morbidity of traditional HIPEC. The combined photothermal and chemotherapy mediated by the AuNP-drug complex showed efficient antitumor effects and activation of immune response while leaving healthy tissues undamaged.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Trap Energy Upconversion-Like Near-Infrared to Near-Infrared Light Rejuvenateable Persistent Luminescence

Xingzhong Chen et al.

Summary: A new type of persistent luminescence phosphors and nanoparticles that can be charged via deep-tissue penetrable near-infrared (NIR) light for regenerating light emission signals have been reported. These materials enable the reverse transition of carriers, allowing for circular charging using low-energy NIR photons and emitting afterglow signals, setting the stage for new biological applications.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Reprogramming the Tumor Microenvironment through Second-Near-Infrared-Window Photothermal Genome Editing of PD-L1 Mediated by Supramolecular Gold Nanorods for Enhanced Cancer Immunotherapy

Honglin Tang et al.

Summary: The photothermal genome-editing strategy using a supramolecular cationic gold nanorod for CRISPR/Cas9 delivery to disrupt PD-L1 and induce immunogenic cell death (ICD) shows promising results in improving immune checkpoint blockade (ICB) therapy. This approach enhances dendritic cell conversion to T cells, promotes infiltration of cytotoxic T lymphocytes into tumors, and reprograms the immunosuppressive tumor microenvironment into an immunoactive one to inhibit primary and metastatic tumor activity with long-term immune memory effects.

ADVANCED MATERIALS (2021)

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Article Multidisciplinary Sciences

Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion

Xiujie Sun et al.

Summary: The study identifies a new mechanism of immune exclusion mediated by DDR1-ECD through promoting collagen fiber alignment. Inhibition of DDR1 promotes intratumoral penetration of T cells and eradicates tumor growth in TNBC.

NATURE (2021)

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Article Oncology

Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline

Larissa A. Korde et al.

Summary: The guideline recommendations for neoadjuvant therapy for breast cancer suggest that patients should be managed by multidisciplinary teams and that appropriate candidates include those with inflammatory breast cancer or residual disease that may prompt a change in therapy.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PEGylated nanomedicines

Zui Zhang et al.

Summary: This study utilized PEG single-chain variable fragment (PEG-scFv) to ameliorate the ABC phenomenon of PEGylated nanomedicines, showing promising results in animal and human experiments. The application of anti-PEG scFv provides a new avenue for improving the performance of PEGylated nanomedicines and mitigating individual differences caused by varying levels of anti-PEG antibodies.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Controlled Synthesis and Surface Engineering of Janus Chitosan-Gold Nanoparticles for Photoacoustic Imaging-Guided Synergistic Gene/Photothermal Therapy

Xiaoguang Dai et al.

Summary: The study developed a series of symmetrical and unsymmetrical chitosan/gold nanoparticles, utilizing the active motion derived from Janus structure, selective surface functionalization of polysaccharide domain, and photothermal effect of gold nanorods to construct Janus-structured chitosan/gold nanohybrids for breast cancer treatment. Investigating the morphology effect of chitosan/gold nanostructures on enhanced PTT, cellular uptake, and gene transfection, as well as exploring the feasibility of PA imaging to track the accumulation of J-ACP and guide PTT.

SMALL (2021)

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Article Multidisciplinary Sciences

Near-infrared manipulation of multiple neuronal populations via trichromatic upconversion

Xuan Liu et al.

Summary: Researchers have developed trichromatic UCNPs with excitation-specific luminescence to independently activate three distinct neuronal populations in awake mice's brains, enabling precise modulation of their behavior.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Temperature-Sensitive Lipid-Coated Carbon Nanotubes for Synergistic Photothermal Therapy and Gene Therapy

Yinan Zhao et al.

Summary: The combination of peptide lipid (PL) and sucrose laurate (SL) coated carbon nanotubes has shown great potential for achieving controlled release of genes for anti-tumor activity through photothermal effects. The resulting SCNT-PS/siRNA delivery system exhibited high anti-tumor activity and efficient systemic delivery to tumor sites.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Postchronic Single-Walled Carbon Nanotube Exposure Causes Irreversible Malignant Transformation of Human Bronchial Epithelial Cells through DNA Methylation Changes

Jin Wang et al.

Summary: Long-term pulmonary exposure to carbon nanotubes (CNTs) can induce carcinogenesis and tumor metastasis. A study on human lung cells exposed to single-walled carbon nanotubes (SWCNTs) showed that postchronic exposure led to increased migration and invasion abilities, irreversible malignant transformation, and promotion of carcinogenesis in vivo through DNA methylation and transcriptome dysregulation.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

MBene as a Theranostic Nanoplatform for Photocontrolled Intratumoral Retention and Drug Release

Danyang Chen et al.

Summary: A new type of MBene, zirconium boride nanosheet (ZBN), was developed as a versatile nanoplatform to achieve near-infrared (NIR)-controlled intratumoral retention and drug release. Surface borate esterfication allowed efficient and stable conjugation of polyol chemotherapeutic drug and NO prodrug, leading to high-efficacy tumor-targeted drug delivery and controlled drug release.

ADVANCED MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Understanding and advancement in gold nanoparticle targeted photothermal therapy of cancer

Nandan Gupta et al.

Summary: The use of gold nanoparticles in photothermal therapy for cancer treatment is highlighted in this communication, showing their potential in warning cancer cells to other therapies, modulating cellular permeability and delivery, and achieving effective therapy management.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Chemistry, Multidisciplinary

Enzyme Activated Gold Nanoparticles for Versatile Site-Selective Bioconjugation

Alexandra Ramsey et al.

Summary: This study introduces a new enzymatic method for constructing protein- and DNA-AuNP conjugates, presenting highly stable AuNPs that can be selectively activated with an enzyme and offer the ability to conjugate proteins or DNA through a diverse set of functional handles. The enzymatic oxidative coupling on AuNPs was applied successfully to the construction of tobacco mosaic virus (TMV)-AuNP conjugates, demonstrating energy transfer between the AuNPs and fluorophores on TMV.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Medicine, General & Internal

Breast cancer

Sibylle Loibl et al.

Summary: Breast cancer diagnosis and treatment have become increasingly complex, incorporating various biomarkers and neoadjuvant therapies, with de-escalation schemes for radiotherapy now becoming standard practice.

LANCET (2021)

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Review Oncology

Evidence-based approaches for the management of side-effects of adjuvant endocrine therapy in patients with breast cancer

Maria Alice Franzoi et al.

Summary: The availability of more effective therapies has led to increased survival rates in breast cancer patients. However, the side-effects of these treatments can impact treatment adherence and patients' quality of life. The goal of cancer care in the 21st century is to mitigate these side-effects and improve patients' quality of life and emotional well-being.

LANCET ONCOLOGY (2021)

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Review Oncology

Novel approaches to target the microenvironment of bone metastasis

Lorenz C. Hofbauer et al.

Summary: Bone metastases are a common and severe complication of advanced-stage cancers, particularly in patients with breast and prostate cancer. The interactions between cells in the bone microenvironment affect tumor cell migration, dormancy, and resistance to treatment, and interrupting these interactions can help prevent or treat skeletal metastases.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Nanoscience & Nanotechnology

Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy

Di Gao et al.

Summary: The development of all-organic oxygen-independent hybrid nanobullets, utilizing surface-modified hyaluronic acid and hypoxia-dependent factors for precise targeting of hypoxic tumors, provides significant therapeutic advantages in suppressing the growth of hypoxic tumors and their metastasis.

NANO-MICRO LETTERS (2021)

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Article Pharmacology & Pharmacy

Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy

Hao Ren et al.

Summary: The self-assembled cascade bioreactor enhances tumor penetration and primary tumor elimination through synergistic therapy, while also promoting immunogenic cell death. This novel treatment strategy has promising potential for inhibiting primary tumors and metastasis.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Nanoscience & Nanotechnology

Virus-Inspired Gold Nanorod-Mesoporous Silica Core-Shell Nanoparticles Integrated with tTF-EG3287 for Synergetic Tumor Photothermal Therapy and Selective Therapy for Vascular Thrombosis

Xian Luo et al.

Summary: The synthesized GNR@VSNP-tTF-EG3287 exerted synergetic effects in tumor therapy by combining selective vascular thrombosis therapy (SVTT) and photothermal therapy (PTT), achieving enhanced antitumor efficiency and affecting both tumor blood supply and cancer cell proliferation.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Multidisciplinary

Biomimetic Nanoparticles Carrying a Repolarization Agent of Tumor-Associated Macrophages for Remodeling of the Inflammatory Microenvironment Following Photothermal Therapy

Yale Yue et al.

Summary: The complete regression of residual tumors after photothermal therapy depends on the activation and recognition of the immune system. This study explored biomimetic nanoparticles carrying repolarization agent of TAMs to remodel the post-PTT inflammatory microenvironment. In a breast tumor model, these nanoparticles significantly elevated the levels of M1-like TAMs, resulting in an increased tumor-elimination rate.

ACS NANO (2021)

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Review Chemistry, Multidisciplinary

Mito-Bomb: Targeting Mitochondria for Cancer Therapy

Xiaolu Guo et al.

Summary: Traditional cancer therapies such as surgery, chemotherapy, and radiotherapy have limited effectiveness, while photodynamic therapy, photothermal therapy, and chemodynamic therapy have shown promising results in cancer treatment due to their high selectivity, minimal resistance, and minimal toxicity.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Triple-Jump Photodynamic Theranostics: MnO2 Combined Upconversion Nanoplatforms Involving a Type-I Photosensitizer with Aggregation-Induced Emission Characteristics for Potent Cancer Treatment

Yuanwei Wang et al.

Summary: The article introduces a method of constructing a nanoplatform for dual-modal imaging-guided photodynamic therapy by depleting glutathione and regulating near-infrared light. This method improves the efficiency of generating reactive oxygen species and monitors tumor sites through magnetic resonance imaging.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Hypoxia-Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild-Photothermal Therapy

Xueqing Li et al.

Summary: This study develops a hypoxia-responsive nanocomposite for mild-photothermal therapy through gene editing in tumors. The technology has the potential to enhance tumor ablation efficiency and reduce damage to surrounding healthy tissues.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Engineering, Biomedical

Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer

Jing Liu et al.

Summary: The development of hypoxia-activatable polymeric micelles for tumor-targeted therapy is effective for eradicating advanced breast cancer by triggering synergistic cytotoxicity and immunogenic cell death. These micelles efficiently deliver drugs and photosensitizers to cancer cells, and have the potential to significantly suppress tumor recurrence and metastasis.

BIOMATERIALS (2021)

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Article Nanoscience & Nanotechnology

An Acceptor-π-Donor Structured Organic Chromophore for NIR Triggered Thermal Ablation of Tumor via DNA Damage-Mediated Apoptosis

Di Zhang et al.

Summary: The paper presents a new organic chromophore named PTM for photothermal therapy of tumors. PTM nanoparticles show robust NIR absorption, high photostability and efficient photothermal conversion, effectively killing tumors via DNA damage-mediated apoptosis. This study provides a promising approach for developing safe and effective photothermal agents for cancer treatment.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Engineering, Environmental

2D graphene oxide particles induce unwanted loss in pluripotency and trigger early differentiation in human pluripotent stem cells

Jiwoong Heo et al.

Summary: This study elucidated the cytotoxic effects of graphene oxide (GO) on human induced pluripotent stem cells (hiPSCs), highlighting the risk of GO uptake and accumulation on stem cell development by unwanted loss in pluripotency and accelerated initiation of differentiation.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Engineering, Environmental

Pulmonary inflammatory and fibrogenic response induced by graphitized multi-walled carbon nanotube involved in cGAS-STING signaling pathway

Bing Han et al.

Summary: GMWCNTs can lead to pulmonary inflammation and fibrosis, but inhibiting the STING pathway can reduce these adverse effects.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Engineering, Environmental

Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells

Feng Xiaoli et al.

Summary: The study reveals that graphene oxide (GO) nanomaterial induces oxidative stress in neural cells, leading to mitochondrial-related cascades and apoptotic cell death. This highlights the significant impact of the structure-related activity of GO on its biological properties.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Review Pharmacology & Pharmacy

Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent

Nefeli Lagopati et al.

Summary: The scientific community has approached the multivariate condition of cancer disease in various ways, with recent focus on individualized treatments and the development of alternative therapeutic schemes. Nanomedicine, particularly nanostructured titanium dioxide, shows promise in filling the gaps and providing effective solutions for cancer treatment by exploiting unique properties of innovative materials. Nanostructured TiO2 is biocompatible and can generate reactive oxygen species to damage cancer cells, suggesting it as a promising anticancer photosensitizer.

PHARMACOLOGY & THERAPEUTICS (2021)

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Article Chemistry, Multidisciplinary

Controlled CRISPR-Cas9 Ribonucleoprotein Delivery for Sensitized Photothermal Therapy

Chao Chen et al.

Summary: A near-infrared light-triggered thermo-responsive copper sulfide multifunctional nanotherapeutic platform was developed for controlled release of CRISPR-Cas9 ribonucleoprotein and doxorubicin, showing potential for synergistic combination therapy in cancer treatment.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Vascular Bursts Act as a Versatile Tumor Vessel Permeation Route for Blood-Borne Particles and Cells

Kazunori Igarashi et al.

Summary: Recent research has highlighted the potential of dynamic bursting in tumor vasculature as a novel route for drug delivery, allowing for the transportation of sub-100 nm nanoparticles into tumors and possibly affecting the access of other blood-borne particles. Mathematical modeling and experimental comparisons have revealed the characteristics and sizes of burst vents in tumor vasculature, as well as different types of therapeutic drugs and cells that can utilize this phenomenon for transportation.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Facile Preparation of MoS2 Nanocomposites for Efficient Potassium-Ion Batteries by Grinding-Promoted Intercalation Exfoliation

Honglei Wang et al.

Summary: A new exfoliation method using grinding-promoted intercalation exfoliation (GPIE) was presented to prepare MoS2-CNC nanocomposites, which showed impressive performance as anode materials for potassium-ion batteries. The method efficiently exfoliates MoS2 nanosheets and produces the nanocomposites in water, opening up a new avenue for high-performance device applications.

SMALL (2021)

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Review Chemistry, Multidisciplinary

Molecular engineering of organic-based agents for in situ bioimaging and phototherapeutics

Ke Li et al.

Summary: In situ monitoring of bioactive molecules is crucial for understanding various biological events, while targeting therapy in situ can improve treatment outcomes and reduce side effects. Strategies for in situ imaging and precision treatment are emphasized in this review, focusing on the application of molecular immobilization techniques.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer

Helena Gavilan et al.

Summary: Magnetic hyperthermia (MHT) is a therapy for solid tumors that requires specific physical and chemical properties in magnetic nanoparticles (MNPs) for effective treatment. In recent years, a new generation of MNPs has been developed for MHT, achieving unprecedented levels of heating efficiency.

CHEMICAL SOCIETY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Engineering in Medicine To Address the Challenge of Cancer Drug Resistance: From Micro- and Nanotechnologies to Computational and Mathematical Modeling

Morgan Craig et al.

Summary: Drug resistance poses a major challenge in cancer treatment, limiting the effectiveness of anticancer drugs and immunotherapies. Engineers from various disciplines are using interdisciplinary tools to address drug resistance, with a focus on nanotechnology, bioengineered tumor models, and computational/mathematical modeling. This interdisciplinary approach has led to discoveries in resistance biology and the development of novel treatment strategies.

CHEMICAL REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Second near-infrared photothermal materials for combinational nanotheranostics

Cheng Xu et al.

Summary: Second near-infrared photothermal therapy (NIR-II PTT) has advantages of deeper penetration and less toxicity, but faces challenges of suboptimal photothermal conversion and limited therapeutic efficacy. To improve efficacy, multifunctional NIR-II photothermal inorganic or organic materials have been developed for combination with other therapeutic modalities.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Acoustics

Eu-doped ZnO nanoparticles: Sonochemical synthesis, characterization, and sonocatalytic application

Alireza Khataee et al.

ULTRASONICS SONOCHEMISTRY (2020)

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Review Chemistry, Multidisciplinary

Combating Concentration Quenching in Upconversion Nanoparticles

Bing Chen et al.

ACCOUNTS OF CHEMICAL RESEARCH (2020)

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Article Engineering, Environmental

Distinct autophagy-apoptosis related pathways activated by Multi-walled (NM 400) and Single-walled carbon nanotubes (NIST-SRM2483) in human bronchial epithelial (16HBE14o-) cells

Manosij Ghosh et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Review Chemistry, Multidisciplinary

Ga-Based Liquid Metal Micro/Nanoparticles: Recent Advances and Applications

Hyunsun Song et al.

SMALL (2020)

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Article Nanoscience & Nanotechnology

All-in-One Silver Nanoprism Platform for Targeted Tumor Theranostics

Xuemei Zeng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Chemistry, Multidisciplinary

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Binbin Ding et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy

Dongmei Xi et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

Wing-Fu Lai et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Compact Assembly and Programmable Integration of Supercapacitors

Bing Lu et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Biomedical

Susceptibility-weighted imaging for metabolic pathway mapping of low-dosage nanoparticles in organisms

Chaolin Song et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Magnetic-induced graphene quantum dots for imaging-guided photothermal therapy in the second near-infrared window

Hongji Liu et al.

BIOMATERIALS (2020)

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Review Chemistry, Multidisciplinary

Importance of Size and Contact Structure of Gold Nanoparticles for the Genesis of Unique Catalytic Processes

Tamao Ishida et al.

CHEMICAL REVIEWS (2020)

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Article Oncology

Low-Dose Anti-Angiogenic Therapy Sensitizes Breast Cancer to PD-1 Blockade

Qian Li et al.

CLINICAL CANCER RESEARCH (2020)

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Article Chemistry, Multidisciplinary

Engineering of Upconverted Metal-Organic Frameworks for Near-Infrared Light-Triggered Combinational Photodynamic/Chemo-/Immunotherapy against Hypoxic Tumors

Yulei Shao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

Atomic-Level Nanorings (A-NRs) Therapeutic Agent for Photoacoustic Imaging and Photothermal/Photodynamic Therapy of Cancer

Yongji Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

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Letter Nanoscience & Nanotechnology

Carbon nanotubes added to the SIN List as a nanomaterial of Very High Concern

Steffen Foss Hansen et al.

NATURE NANOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Biodegradable Bi2O2Se Quantum Dots for Photoacoustic Imaging-Guided Cancer Photothermal Therapy

Hanhan Xie et al.

SMALL (2020)

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Article Multidisciplinary Sciences

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Min Li et al.

NATURE COMMUNICATIONS (2020)

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Article Engineering, Biomedical

First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows

Zhenhua Hu et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Review Chemistry, Multidisciplinary

Photonic Carbon Dots as an Emerging Nanoagent for Biomedical and Healthcare Applications

You Jung Chung et al.

ACS NANO (2020)

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Review Pharmacology & Pharmacy

A moderate thermal dose is sufficient for effective free and TSL based thermochemotherapy

G. C. van Rhoon et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Engineering, Biomedical

Pd@Au Bimetallic Nanoplates Decorated Mesoporous MnO2 for Synergistic Nucleus-Targeted NIR-II Photothermal and Hypoxia-Relieved Photodynamic Therapy

Yiyi Zhang et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Engineering, Biomedical

Less is more: Silver-AIE core@shell nanoparticles for multimodality cancer imaging and synergistic therapy

Xuewen He et al.

BIOMATERIALS (2020)

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Review Oncology

Overcoming Endocrine Resistance in Breast Cancer

Ariella B. Hanker et al.

CANCER CELL (2020)

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Review Nanoscience & Nanotechnology

Insights into Theranostic Properties of Titanium Dioxide for Nanomedicine

Morteza Hasanzadeh Kafshgari et al.

NANO-MICRO LETTERS (2020)

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Article Nanoscience & Nanotechnology

Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window

Xunzhi Wu et al.

NANO-MICRO LETTERS (2020)

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Editorial Material Oncology

Lumpectomy Margins for Invasive Breast Cancer and Ductal Carcinoma in Situ: Current Guideline Recommendations, Their Implications, and Impact

Stuart J. Schnitt et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

Chemical and Colloidal Dynamics of MnO2 Nanosheets in Biological Media Relevant for Nanosafety Assessment

Evan P. Gray et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

Photoactivated H2 Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

Rui Sun et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Bortezomib-Encapsulated CuS/Carbon Dot Nanocomposites for Enhanced Photothermal Therapy via Stabilization of Polyubiquitinated Substrates in the Proteasomal Degradation Pathway

Ying Yu et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Breast intraductal nanoformulations for treating ductal carcinoma in situ I: Exploring metal -ion complexation to slow ciclopirox release, enhance mammary persistence and efficacy

Firas Al-Zubaydi et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Engineering, Environmental

Increased telomere length and mtDNA copy number induced by multi-walled carbon nanotube exposure in the workplace

Manosij Ghosh et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Nanoscience & Nanotechnology

Near-Infrared Upconversion Mesoporous Tin Oxide Bio-Photocatalyst for H2O2-Activatable O2-Generating Magnetic Targeting Synergetic Treatment

Lili Feng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Dual-Metal Interbonding as the Chemical Facilitator for Single-Atom Dispersions

Yao Zhou et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Tumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon-Dot-Cu2+Nanoassemblies

Shan Sun et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Engineering, Biomedical

Biodegradable Poly(gamma-glutamic acid)@glucose oxidase@carbon dot nanoparticles for simultaneous multimodal imaging and synergetic cancer therapy

Ming Zhang et al.

BIOMATERIALS (2020)

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Review Oncology

Clinical development and potential of photothermal and photodynamic therapies for cancer

Xingshu Li et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

Flexible Photothermal Assemblies with Tunable Gold Patterns for Improved Imaging-Guided Synergistic Therapy

Di Zheng et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

Comparative Effects of Graphene and Molybdenum Disulfide on Human Macrophage Toxicity

Hazel Lin et al.

SMALL (2020)

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Review Medicine, Research & Experimental

HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer

Ellen C. de Heer et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Chemistry, Physical

Applications and challenges of thermoplasmonics

Guillaume Baffou et al.

NATURE MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Improved Stability and Photothermal Performance of Polydopamine-Modified Fe3O4Nanocomposites for Highly Efficient Magnetic Resonance Imaging-Guided Photothermal Therapy

Bo Li et al.

SMALL (2020)

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Article Nanoscience & Nanotechnology

Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

Songtao Zhang et al.

NANO-MICRO LETTERS (2020)

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Article Nanoscience & Nanotechnology

Biodegradable Multifunctional Nanotheranostic Based on Ag2S-Doped Hollow BSA-SiO2 for Enhancing ROS-Feedback Synergistic Antitumor Therapy

Ziliang Zheng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Biochemistry & Molecular Biology

A Step Forward in Breast Cancer Research: From a Natural-Like Experimental Model to a Preliminary Photothermal Approach

Eduardo Costa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Lanthanide-doped inorganic nanoparticles turn molecular triplet excitons bright

Sanyang Han et al.

NATURE (2020)

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Article Cell Biology

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