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Review
Pharmacology & Pharmacy
Zeyu Xu et al.
Summary: Impaired wound healing in chronic wounds has always been a significant challenge for clinicians and researchers. Traditional herbal medicine has a long history of promoting wound healing and is widely accepted and trusted by people around the world. However, the understanding of herbal medicine has been limited, and its therapeutic effects are found to be less pronounced compared to synthetic chemical medicine. This article reviews the mechanisms of the skin microbiome in the wound healing process, the role of herbal medicine in regulating immune responses and commensal microbiome, and proposes pioneer ideas and studies in the development of therapeutic strategies for controlled delivery of herbal medicine. The review aims to promote wound care focusing on wound microbiome, immune response, and topical drug delivery systems. Lastly, future development trends, challenges, and research directions are discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Yanting Shen et al.
Summary: Injectable fibro-gel, a water-filled network of entangled hydrogel microfibers, has shown great potential in tissue engineering and regenerative medicine due to its injectability, tailorable physicochemical properties, and controlled drug release profiles. Preliminary in vivo tests on a mice excision skin model have demonstrated that the fibro-gel promotes faster wound healing and new tissue regeneration compared to a commercial gel. Moreover, the release of distinct drugs at different rates using a two-layer fibro-gel model further enhances wound healing efficiency.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Minhui Lu et al.
Summary: Detection of biomarkers associated with wound conditions provides in-depth healthcare information and benefits wound healing treatment.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yuan Xiong et al.
Summary: Diabetic wound therapy is a significant challenge in medicine. A whole-course-repair system using a hydrogel has been introduced to achieve concurrent neurogenesis and angiogenesis for accelerated wound healing. The hydrogel can be injected into wounds to provide a physical barrier and release magnesium ions and engineered small extracellular vesicles for synergistic effects. This system recruits mesenchymal stem cells and stimulates neurogenic differentiation, while also promoting angiogenesis at the wound site. It offers a novel platform for combined diabetic wound therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Johnson John et al.
Summary: This study introduces a strategy to use nanofiber aerogels combined with the LL-37-mimic peptide W379 for accelerated healing of diabetic wounds, showing great potential for clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yuna Qian et al.
Summary: A novel glycyrrhizic acid-based hybrid hydrogel dressing with intrinsic immunoregulatory properties is developed to promote rapid diabetic wound healing.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Abhinanda Kar et al.
Summary: Poor adherence to drug dosing schedule contributes to around 50% of hospitalizations. The concept of wearable, implantable, and combined devices has opened up new opportunities for treating chronic diseases that require long-term medication. Wearable devices, worn on the body surface, are non-invasive and self-administrable, while implantable devices allow for higher drug payload and localized effects.
Article
Chemistry, Multidisciplinary
Baohui Chen et al.
Summary: Skin wounds, especially infected chronic wounds, have become a major concern worldwide. Researchers have developed a Chinese-herb-based hydrogel with antibacterial and immune regulation properties using a mechanosynthesis approach. The hydrogel demonstrated a high antibacterial rate of over 95% and a wound closure rate twice that of the control group. The hydrogel's formation, physical and chemical properties, and biological performance can be precisely controlled by adjusting the ratios of herbal components. The synergistic antibacterial and immune regulation properties of the hydrogel contribute to killing bacteria and reducing inflammation, ensuring effective infection control and promoting wound healing.
Review
Biotechnology & Applied Microbiology
Maryam Sharifiaghdam et al.
Summary: This review examines the role of macrophages in the wound healing process and the aberrations that occur in macrophages under diabetic conditions. Recent macrophage-based therapeutic approaches, including delivery of ex-vivo-activated macrophages and pharmacological strategies, are discussed. Specifically, strategies to silence key regulator genes and repolarize wound macrophages to the M2 phenotype are highlighted, along with their potential future clinical translation.
Review
Multidisciplinary Sciences
Shruti Naik et al.
Summary: Our body has the ability to remember past encounters, react more quickly to new threats, and develop resistance to subsequent pathogens. This memory is not limited to the immune system but also extends to epithelia and neurons. However, these memories can also lead to chronic inflammatory disorders and an increased risk of cancer.
Article
Engineering, Biomedical
Xiaoling Zeng et al.
Bioactive Materials
(2022)
Article
Nanoscience & Nanotechnology
Yang Gao et al.
Summary: The SAAMs microcapsules demonstrate excellent hemostatic properties and antimicrobial activities, promoting wound healing with multifunctionality in different stages of the healing process.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Wei Nie et al.
Summary: A graphene-based scaffold with intact conjugated structure was prepared by chemical vapor deposition, and biomimetic mineralization was achieved by a semi-dry electrochemical deposition method, forming a hydroxyapatite-incorporated graphene scaffold. The scaffold exhibited high photothermal sensitivity and improved osteogenic activity, and could regulate the immune microenvironment for the treatment of tumor-induced bone defects.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Zhenghao Wang et al.
Summary: A shape-adaptable, biodegradable, biocompatible interleukin-33 (IL-33)-cytogel has been developed by encapsulating IL-33 into physically cross-linked DNA hydrogels for promoting diabetic wound healing. The IL-33-cytogel releases IL-33 into the wound area for at least 7 days, inducing the accumulation of specific cells and promoting the transition of cells for improved inflammation resolution and wound healing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Immunology
Christopher O. Audu et al.
Summary: JMJD3 plays a central role in the regulation of macrophage plasticity during tissue repair, and its dysregulation in diabetic wounds leads to persistent inflammation. IL-6, through the JAK1,3/STAT3 pathway, regulates JMJD3 expression in diabetic wound macrophages and contributes to inflammatory gene transcription. JMJD3 also regulates the STING gene, which plays a dual role in macrophage inflammation during wound healing and in diabetic wounds.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Mayland Chang et al.
Summary: Diabetic foot ulcers (DFUs) are chronic wounds that affect 30% of diabetic patients, with dysregulation of the normal wound healing process. Infection in DFUs increases inflammation and delays wound healing. Selective inhibition of MMP-9 may be a promising strategy for treatment of DFUs.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Engineering, Biomedical
Hao Cheng et al.
Summary: The study introduces a novel sprayable hydrogel wound dressing loaded with cerium oxide nanoparticles and an antimicrobial peptide, providing ROS-scavenging and antibacterial properties. By adopting a mussel-inspired strategy, the hydrogel exhibited improved binding affinity to wet skin surfaces and demonstrated excellent biocompatibility.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Multidisciplinary
Jingjing Gan et al.
Summary: This study presents a pH-sensitive drug delivery system for oral treatment of inflammatory bowel disease, which can significantly decrease the production of TNF-alpha in colitis animal models and alleviate colitis symptoms in mice after oral administration. The designed system shows promising potential in treating colon-associated diseases.
APPLIED MATERIALS TODAY
(2021)
Article
Engineering, Biomedical
Lu Chen et al.
Summary: The study developed an Inner-Outer IL-10-loaded electrospun fiber with cascade release behavior, which programmatically activated sequential immune responses during wound healing by releasing IL-10 and anti-fibrotic cytokines secreted by polarized M2c, leading to scarless skin regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Guodong Li et al.
Summary: This study reports the design and synthesis of a small molecule stabilizer of HIF-1 alpha, which promotes wound healing in diabetic patients according to experiments in mouse models. The compound accelerates wound closure in both normal and diabetic mice, with a greater effect observed in diabetic mice, indicating its potential as a therapeutic agent for diabetic wounds.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Ning Tang et al.
Summary: Smart wound dressings integrated with multifunctional materials, wearable sensors, and drug delivery systems can monitor wounds and provide timely diagnosis and treatment, but there are still challenges to be addressed in their development and application.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Ya Guan et al.
Summary: The study developed a sustained oxygenation system using oxygen-release microspheres and a reactive oxygen species (ROS)-scavenging hydrogel to promote diabetic wound healing. The sustained release of oxygen enhanced cell survival and migration, angiogenic growth factor expression, angiogenesis, and decreased proinflammatory cytokine expression in diabetic wounds, leading to a significant increase in wound closure rate.
Article
Engineering, Environmental
Lanjie Lei et al.
Summary: This study introduces novel multifunctional biohybrid microspheres for one-step protein separation and their application in chronic wound healing. By capturing and isolating the growth factor bFGF and combining with natural anti-inflammatory and anti-oxidative agents, these microspheres show significant promotion of angiogenesis in chronic wounds. This flexible and biohybrid microsphere system has potential for various bioactive proteins design and biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Engineering, Biomedical
Ruoyu Cheng et al.
Review
Cell Biology
Helmut Sies et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2020)
Review
Pharmacology & Pharmacy
Sanket Shah et al.
ADVANCED DRUG DELIVERY REVIEWS
(2020)
Article
Multidisciplinary Sciences
Jiang Ouyang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Chemistry, Multidisciplinary
Junyi Che et al.
ADVANCED MATERIALS
(2020)
Article
Chemistry, Multidisciplinary
Haibin Wu et al.
ACS CENTRAL SCIENCE
(2019)
Review
Pharmacology & Pharmacy
Xiaojiaoyang Li et al.
PHARMACOLOGICAL RESEARCH
(2019)
Editorial Material
Immunology
Johanna A. Knipper et al.
Review
Physiology
Melanie Rodrigues et al.
PHYSIOLOGICAL REVIEWS
(2019)
Review
Biochemistry & Molecular Biology
Akhand Pratap Singh et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2019)
