Time-restricted eating for chronodisruption-related chronic diseases

The circadian timing system enables organisms to adapt their physiology and behavior to the cyclic environmental changes including light-dark cycle or food availability. Misalignment between the endogenous circadian rhythms and external cues is known as chronodisruption and is closely associated with the development of metabolic and gastrointestinal disorders, cardiovascular diseases, and cancer. Time-restricted eating (TRE, in human) is an emerging dietary approach for weight management. Recent studies have shown that TRE or time-restricted feeding (TRF, when referring to animals) has several beneficial health effects, which, however, are not limited to weight management. This review summarizes the effects of TRE/TRF on regulating energy metabolism, gut microbiota and homeostasis, development of cardiovascular diseases and cancer. Furthermore, we will address the role of circadian clocks in TRE/TRF and propose ways to optimize TRE as a dietary strategy to obtain maximal health benefits.

Automated summary

The circadian timing system allows organisms to adapt to cyclic environmental changes. Misalignment between internal rhythms and external cues is associated with various diseases. Time-restricted eating has emerged as a dietary approach with multiple health benefits beyond weight management. This review discusses the effects of time-restricted eating on energy metabolism, gut microbiota, cardiovascular health, and cancer, as well as the role of circadian clocks in optimizing this dietary strategy.