期刊
ACS NANO
卷 17, 期 20, 页码 20445-20461出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.3c06967
关键词
radiotherapy; covalent organic framework nanozymes; ferroptosis; ferrocene; iodine
This study reports a iodine- and ferrocene-loaded covalent organic framework (COF) nanozyme that enhances the efficacy of radiotherapy for radioresistant esophageal cancer. The nanozyme increases X-ray absorption and reactive oxygen species production, while disrupting redox homeostasis. Both in vitro and in vivo experiments demonstrate the excellent radiotherapeutic response of the nanozyme.
Radiotherapy is inevitably accompanied by some degree of radiation resistance, which leads to local recurrence and even therapeutic failure. To overcome this limitation, herein, we report the room-temperature synthesis of an iodine- and ferrocene-loaded covalent organic framework (COF) nanozyme, termed TADI-COF-Fc, for the enhancement of radiotherapeutic efficacy in the treatment of radioresistant esophageal cancer. The iodine atoms on the COF framework not only exerted a direct effect on radiotherapy, increasing its efficacy by increasing X-ray absorption, but also promoted the radiolysis of water, which increased the production of reactive oxygen species (ROS). In addition, the ferrocene surface decoration disrupted redox homeostasis by increasing the levels of hydroxyl and lipid peroxide radicals and depleting intracellular antioxidants. Both in vitro and in vivo experiments substantiated the excellent radiotherapeutic response of TADI-COF-Fc. This study demonstrates the potential of COF-based multinanozymes as radiosensitizers and suggests a possible treatment integration strategy for combination oncotherapy.
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