Multifunctional MXene-Based Bioactive Materials for Integrated Regeneration Therapy

Article Biochemical Research Methods

A dynamic DNA tetrahedron framework for active targeting

Taoran Tian et al.

Summary: An active targeting strategy-enabled DNA tetrahedron delivery vehicle has been developed for stable drug encapsulation and stimuli-responsive on-demand release, providing a universal platform for various drug delivery requirements.

NATURE PROTOCOLS (2023)

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Article Chemistry, Multidisciplinary

Multi-Mechanism Antibacterial Strategies Enabled by Synergistic Activity of Metal-Organic Framework-Based Nanosystem for Infected Tissue Regeneration

Wenjia Xie et al.

Summary: The development of a MOFs-based nanosystem (AgNPs@MOFs) with enhanced visible light response and charge carrier separation, through modifying MOFs with silver nanoparticles (AgNPs), shows promising potential as a nano antibacterial medicine against drug-resistant bacteria for infected tissue regeneration.

SMALL (2023)

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Article Chemistry, Multidisciplinary

Functionalized DNA Nanomaterials Targeting Toll-Like Receptor 4 Prevent Bisphosphonate-Related Osteonecrosis of the Jaw via Regulating Mitochondrial Homeostasis in Macrophages

Tao Zhang et al.

Summary: A tetrahedral DNA nanomaterial (TDN-TLR4-4siR) modified with Toll-like receptor 4 (TLR4) siRNA on each vertex successfully reversed the imbalance in polarization of M1 macrophages induced by Zoledronic Acid (ZA) treatment, reducing the proportion of M1 macrophages. TDN-TLR4-4siR also decreased intracellular ROS production and restored mitochondrial membrane potential. Additionally, the TDN-TLR4-4siR group exhibited decreased sequestra formation and accelerated healing of the extraction wound, resulting in a reduced incidence of rat BRONJ by reprogramming polarized macrophages. Therefore, this study establishes a novel strategy using TDN-TLR4-4siR nanomaterial to regulate mitochondrial homeostasis of polarized macrophages to prevent BRONJ.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Article Engineering, Biomedical

Electrically conductive 3D printed Ti 3 C 2 T x MXene-PEG composite constructs for cardiac tissue engineering

Gozde Basara et al.

Summary: A new composite construct has been developed in this study, which can provide both conductive and topographical cues for cardiac tissue engineering applications, potentially for the treatment of myocardial infarction.

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

2D Ti3C2TxMXene couples electrical stimulation to promote proliferation and neural differentiation of neural stem cells

Rongrong Guo et al.

Summary: Ti3C2Tx MXene nanosheets have shown the potential to regulate the fate of neural stem cells (NSCs) by promoting their proliferation and neural differentiation. NSCs cultured on Ti(3)C(2)T(x)MXene films exhibit enhanced electrical activity and more mature neurons with longer neurites and increased branching. Electrical stimulation applied through the Ti(3)C(2)T(x)MXene film further enhances NSC proliferation. This study expands the potential applications of MXene materials and provides new strategies for stem cell research.

ACTA BIOMATERIALIA (2022)

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Review Materials Science, Multidisciplinary

Structure and synthesis of MAX phase materials: a brief review

Xin Lei et al.

Summary: MAX phase materials are a new family of ternary layered compounds with unique physical properties combining metals and ceramics, widely used in aerospace, nuclear industry, high-speed rail, and other fields. In recent years, there has been heightened interest in MXenes derived from MAX phases.

CRITICAL REVIEWS IN SOLID STATE AND MATERIALS SCIENCES (2022)

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Article Spectroscopy

Detection of glucose in diabetic tears by using gold nanoparticles and MXene composite surface-enhanced Raman scattering substrates

Xiaoyu Cui et al.

Summary: A sensitive and stable GMXeP SERS substrate has been designed for detecting glucose concentration in tears of diabetic patients. The study demonstrates its suitability for sensitive and noninvasive detection of blood glucose.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Engineering, Biomedical

2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

Yunjie Xu et al.

Summary: This study reports a dual-therapeutic prodrug that enables iron chelation chemotherapy and photothermal cancer therapy to be photo-activated. It offers a promising iron chelation-based phototherapeutic approach to cancer therapy.

BIOACTIVE MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Artificial Nonenzymatic Antioxidant MXene Nanosheet-Anchored Injectable Hydrogel as a Mild Photothermal-Controlled Oxygen Release Platform for Diabetic Wound Healing

Yang Li et al.

Summary: This study develops an injectable hydrogel based on MXene nanosheets for diabetic wound healing. The hydrogel utilizes oxyhemoglobin to release oxygen controllably and MXene to scavenge reactive oxygen species and bacteria. The hydrogel also benefits from the regulation of macrophage polarization. Overall, it effectively promotes the healing of infected diabetic wounds.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System

Jiajie Li et al.

Summary: Peripheral nerve injury is a significant global health issue that affects the well-being of millions of individuals. Despite advancements in nerve tissue engineering, complete functional recovery is still not guaranteed. This study explores a novel approach using a multifunctional nucleic acid system to enhance communication between nerve cells and improve functional rehabilitation.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

A Lysosome-Activated Tetrahedral Nanobox for Encapsulated siRNA Delivery

Yang Gao et al.

Summary: Researchers have developed a dynamic lysosome-activated tetrahedral framework nucleic acid (tFNA) nanobox for encapsulating siRNA and achieving controlled release in cells, demonstrating excellent RNA protection and release effects.

ADVANCED MATERIALS (2022)

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Article Engineering, Multidisciplinary

A facile strategy toward hierarchically porous composite scaffold for osteosarcoma ablation and massive bone defect repair

Tingxian Ling et al.

Summary: In this study, a cooking-inspired strategy was developed to fabricate a porous composite scaffold for bone tumor ablation and massive bone defect repair. The scaffold, made of silk fibroin, Ti3C2 MXene nanosheets, and bacterial cellulose, showed outstanding performance in osteosarcoma ablation and bone defect repair after near-infrared light irradiation.

COMPOSITES PART B-ENGINEERING (2022)

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Article Chemistry, Physical

Versatile Ti3C2Tx MXene for free-radical scavenging

Jiang Liu et al.

Summary: This study demonstrated the unique feature of MXene-Ti3C2Tx nanosheets in free-radical scavenging and designed a colorimetric H2O2 strip assay with good performance. The research systematically confirmed the scavenging capability of Ti3C2Tx for a series of reactive oxygen species and reactive nitrogen species, as well as its antioxidation capability in protecting cells from oxidative damage. This original work provides significant opportunities for MXenes in free-radical-related biomedical applications.

NANO RESEARCH (2022)

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Article Biotechnology & Applied Microbiology

Self-redox reaction driven in situ formation of Cu2O/Ti3C2Tx nanosheets boost the photocatalytic eradication of multi-drug resistant bacteria from infected wound

Ya-Ju Hsu et al.

Summary: Cu2O/Ti3C2Tx nanosheets with superior catalytic and photothermal properties have been developed for efficient antimicrobial applications through NIR illumination, showing promising potential for treating infected wounds.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Materials Science, Biomaterials

Surface Modification of Carbon Fiber-Reinforced Polyetheretherketone with MXene Nanosheets for Enhanced Photothermal Antibacterial Activity and Osteogenicity

Tianhui Du et al.

Summary: In this study, CFPEEK implants were surface modified with Ti3C2Tx nanosheets to enhance their photothermal antibacterial activity and osteogenicity. The modified materials showed effective bacterial inhibition and promoted bone formation.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Chemistry, Multidisciplinary

A Tetrahedral Framework DNA-Based Bioswitchable miRNA Inhibitor Delivery System: Application to Skin Anti-Aging

Songhang Li et al.

Summary: MicroRNA-based therapy shows great potential, but its biomedical functionality is limited by structural challenges. A novel bioswitchable miR inhibitor delivery system (BiRDS) is designed using a tetrahedral framework DNA (tFNA) as a vehicle to maximize miR inhibitor loading capacity and improve delivery efficacy.

ADVANCED MATERIALS (2022)

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Review Engineering, Biomedical

Recent advances and trends in the applications of MXene nanomaterials for tissue engineering and regeneration

Yongjin Zhong et al.

Summary: This review summarizes the applications of MXene nanomaterials in tissue engineering and regeneration. The synthesis and surface modification engineering of MXene are briefly introduced, followed by a focus on its application and development in skin, bone, nerve, and heart tissue engineering. Research on MXene with potential future trends in tissue engineering and regeneration is also discussed.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2022)

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Article Engineering, Biomedical

Sponge-Like Macroporous Hydrogel with Antibacterial and ROS Scavenging Capabilities for Diabetic Wound Regeneration

Cheng Wei et al.

Summary: A novel sponge-like macro-porous hydrogel (SM-hydrogel) with stable macro-porous structures and anti-swelling performances is developed using Ti3C2 MXene additives. The hydrogel exhibits versatile functions such as facilitating mass transport, antibacterial properties, and reactive oxygen species scavenging capacities, and it shows great potential for wound tissue engineering.

ADVANCED HEALTHCARE MATERIALS (2022)

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Article Engineering, Biomedical

An NIR photothermal-responsive hybrid hydrogel for enhanced wound healing

Lin Jin et al.

Summary: This study developed a band-aid with a core-shell structure to modulate vascularization and the immune microenvironment, leading to scarless wound healing. The band-aid released H2S and a growth factor, which controlled macrophage polarization and inhibited excessive inflammation, thereby promoting skin cell proliferation and facilitating wound healing.

BIOACTIVE MATERIALS (2022)

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Article Materials Science, Biomaterials

Flexible, high-strength and multifunctional polyvinyl alcohol/MXene/polyaniline hydrogel enhancing skin wound healing

Sudan Liu et al.

Summary: Nature-inspired flexible and multifunctional hydrogels are ideal for tissue repair, especially in skin healing. In this study, high-strength, conductive, and antibacterial polyvinyl alcohol hydrogels with MXene and PANI were developed to enhance wound healing. These hydrogels exhibit excellent mechanical properties, high electrical conductivity, and antibacterial ability, effectively inhibiting bacterial activity and promoting cell proliferation and migration. Moreover, they accelerate wound healing by promoting angiogenesis and collagen deposition.

BIOMATERIALS SCIENCE (2022)

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Article Chemistry, Multidisciplinary

3D printing of MXene composite hydrogel scaffolds for photothermal antibacterial activity and bone regeneration in infected bone defect models

Ran Nie et al.

Summary: This study developed a personalized MXene composite hydrogel scaffold GTAM for the repair of infected bone defects. The GTAM scaffold showed excellent photothermal antibacterial and osteogenic abilities and promoted the healing of infection and bone regeneration.

NANOSCALE (2022)

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Article Materials Science, Biomaterials

2D titanium carbide(MXene) nanosheets and 1D hydroxyapatite nanowires into free standing nanocomposite membrane: in vitro and in vivo evaluations for bone regeneration

Yu Fu et al.

Summary: The study developed a new nanocomposite membrane by introducing ultralong hydroxyapatite nanowires (UHAPNWs) into MXene, showing significant potential in bone regeneration. In vitro and in vivo experiments demonstrated enhanced mechanical properties, cell adhesion, and bone tissue formation when using the nanocomposite membrane.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

Niobium Carbide MXene Augmented Medical Implant Elicits Bacterial Infection Elimination and Tissue Regeneration

Chuang Yang et al.

Summary: 2D niobium carbide (Nb2C) MXene titanium plate Nb2C@TP)-based clinical implant offers practical multimodal anti-infection functions, capable of destroying biofilms for direct bacteria elimination through down-regulating bacterial energy metabolism pathways, suppressing biofilm formation, and enhancing biofilm detachment via activating the accessory gene regulator.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Highly Electroconductive and Mechanically Strong Ti3C2Tx MXene Fibers Using a Deformable MXene Gel

Hwansoo Shin et al.

Summary: MXene nanosheets self-assembled into hydrogels can be spun into highly aligned fibers with increased electrical conductivity and Young's modulus. These oriented MXene fibers are expected to have widespread applications in electrical wiring and signal transmission.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Combinatorial Photothermal 3D-Printing Scaffold and Checkpoint Blockade Inhibits Growth/Metastasis of Breast Cancer to Bone and Accelerates Osteogenesis

Chao He et al.

Summary: A BG@NbSiR scaffold has been developed to effectively treat bone metastasis of breast cancer by activating immune response, suppressing metastases, preventing tumor relapses, and promoting osteogenesis. Single-cell sequencing has been used to identify critical factors responding to this scaffold-based therapy, providing insights into underlying therapeutic mechanisms.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Biophysics

A multimodal antimicrobial platform based on MXene for treatment of wound infection

Xia Xu et al.

Summary: In this study, a composite nanofibrous membrane containing amoxicillin, MXene, and polyvinyl alcohol was developed, demonstrating high antibacterial and accelerated wound healing capacity.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Nanoscience & Nanotechnology

Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects

Junhui Yin et al.

Summary: The engineered composite scaffolds integrating 2D Nb2C MXene show efficient treatment of bone tumor by killing cancer cells and promoting angiogenesis and bone regeneration.

NANO-MICRO LETTERS (2021)

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Article Chemistry, Physical

Ultraefficiently Calming Cytokine Storm Using Ti3C2Tx MXene

Tianyi Wang et al.

Summary: This study discovered that MXene sheet demonstrates an ultrahigh removal capability for typical cytokine interleukin-6 and exhibits excellent blood compatibility, offering a new avenue for using MXene sheets as an ultra-efficient hemoperfusion absorbent to eliminate cytokine storm syndrome in severe COVID-19 patients.

SMALL METHODS (2021)

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Article Chemistry, Multidisciplinary

Conductive Antibacterial Hemostatic Multifunctional Scaffolds Based on Ti3C2Tx MXene Nanosheets for Promoting Multidrug-Resistant Bacteria-Infected Wound Healing

Li Zhou et al.

Summary: The study utilized 2D Ti3C2Tx MXene to develop multifunctional scaffolds HPEM for MRSA-infected wound healing. HPEM scaffolds displayed properties such as self-healing behavior, electrical conductivity, tissue-adhesive feature, and antibacterial activity, significantly promoting wound healing.

ACS NANO (2021)

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Article Chemistry, Multidisciplinary

Modulation of Local Overactive Inflammation via Injectable Hydrogel Microspheres

Jiang Bian et al.

Summary: The injectable peptide-cell-hydrogel microsphere showed promising results in regulating ECM metabolism and inhibiting inflammatory responses, providing an effective approach for tissue regeneration under overactive inflammatory conditions.

NANO LETTERS (2021)

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Article Multidisciplinary Sciences

Interfacial engineering of Bi2S3/Ti3C2Tx MXene based on work function for rapid photo-excited bacteria-killing

Jianfang Li et al.

Summary: An interfacial Schottky junction of Bi2S3/Ti3C2Tx has been designed to improve photocatalytic activity by increasing local electron density and inhibiting electron backflow, effectively eradicating Staphylococcus aureus and Escherichia coli.

NATURE COMMUNICATIONS (2021)

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Article Immunology

Severe Altered Immune Status After Burn Injury Is Associated With Bacterial Infection and Septic Shock

Helene Moins-Teisserenc et al.

Summary: This study explored the association between immune and inflammatory responses and outcomes in severely ill burn patients. The findings suggest that burn injury induces alterations in immune responses, with an upregulation of adaptive immunity and activation biomarkers and a down regulation of innate immunity and stress/inflammation biomarkers. Immune and inflammatory responses were found to be associated with bacterial infections and septic shock, with absence of immune recovery patterns being linked to poor prognosis.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Sequential Release of Small Extracellular Vesicles from Bilayered Thiolated Alginate/Polyethylene Glycol Diacrylate Hydrogels for Scarless Wound Healing

Yifan Shen et al.

Summary: The study developed bilayered thiolated alginate/PEG diacrylate (BSSPD) hydrogels for sequential release of different types of sEVs to promote wound healing. The results showed that phased release of sEVs can achieve scarless wound healing more quickly and effectively.

ACS NANO (2021)

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Review Engineering, Biomedical

MXene in the lens of biomedical engineering: synthesis, applications and future outlook

Adibah Zamhuri et al.

Summary: MXene is a multifaceted 2D material with unique physicochemical properties and biocompatibility, suitable for applications in biomedicine and biotechnology such as drug delivery and bio-imaging.

BIOMEDICAL ENGINEERING ONLINE (2021)

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Article Engineering, Environmental

Bioactive anti-inflammatory, antibacterial, conductive multifunctional scaffold based on MXene@CeO2 nanocomposites for infection-impaired skin multimodal therapy

Hua Zheng et al.

Summary: This study successfully developed multifunctional MXene@CeO2 nanocomposites for a hydrogel scaffold with various properties for treating MDR-infected skin, including self-healing, anti-inflammatory, antibacterial, antioxidative, conductive, tissue-adhesive, and hemostatic capabilities. The scaffold showed efficacy in promoting cell migration and proliferation, accelerating wound healing, and addressing multidrug resistant infections.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Environmental

Injectable antibacterial antiinflammatory molecular hybrid hydrogel dressing for rapid MDRB-infected wound repair and therapy

Wei Cheng et al.

Summary: The PCGS-based hydrogel dressing shows great potential in treating MDRB-infected wounds and skin repair by effectively inhibiting infection, promoting wound healing, and enhancing skin appendage construction. In vivo studies demonstrate significant therapeutic effects of the dressing.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Engineering, Biomedical

Ca2+-supplying black phosphorus-based scaffolds fabricated with microfluidic technology for osteogenesis

Zhanrong Li et al.

Summary: The new 3D nanocomposite fibrous scaffold developed using microfluidic technology provides essential ions to promote osteogenesis effectively. This innovative approach has shown promising results in promoting bone regeneration in both in vitro and in vivo experiments.

BIOACTIVE MATERIALS (2021)

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Article Materials Science, Multidisciplinary

NIR-responsive MXene nanobelts for wound healing

Lin Jin et al.

Summary: The study successfully prepared temperature-responsive MXene nanosheet/nanobelt fibers carrying vitamin E with a controllable release ability for wound healing, showcasing excellent biocompatibility and wound-healing functions.

NPG ASIA MATERIALS (2021)

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Correction Chemistry, Multidisciplinary

Healable, Degradable and Conductive MXene Nanocomposite Hydrogel for Multifunctional Epidermal Sensor (vol 15, pg 7765, 2021)

Xiaobin Li et al.

ACS NANO (2021)

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Article Engineering, Biomedical

Near-infrared light-controllable MXene hydrogel for tunable on-demand release of therapeutic proteins

Song Wang et al.

Summary: An injectable and Near-infrared (NIR) light-responsive MXene-hydrogel has been developed for precise control of therapeutic protein drugs release in vivo, showing great potential in tissue repair and cancer therapy through a series of experiments.

ACTA BIOMATERIALIA (2021)

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Review Chemistry, Multidisciplinary

Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Mahshid Kharaziha et al.

Summary: The immune reaction plays a critical role in chronic wound healing, with modulation of macrophages' polarization being an appealing approach in regenerative medicine. The use of hydrogels-based constructs has been recently developed to adjust immune cell functions in various stages of wound healing. The properties of hydrogels have significant effects on immunogenic features and the wound healing process.

ADVANCED MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Advances in the Synthesis of 2D MXenes

Yi Wei et al.

Summary: MXenes, versatile materials with adjustable structures and rich surface chemistry, have been recognized as potential 2D materials for various applications. Recent research has focused on synthetic routes, etching methods, and delamination strategies for large-scale preparation and stable storage. Antioxidation strategies for MXenes have also been summarized for future developments and practical applications.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Hypoxia-Responsive Gene Editing to Reduce Tumor Thermal Tolerance for Mild-Photothermal Therapy

Xueqing Li et al.

Summary: This study develops a hypoxia-responsive nanocomposite for mild-photothermal therapy through gene editing in tumors. The technology has the potential to enhance tumor ablation efficiency and reduce damage to surrounding healthy tissues.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Editorial Material Materials Science, Ceramics

A decade of discovery: A review of MXenes, the family of 2D transition metal carbides and nitrides

Yury Gogotsi

AMERICAN CERAMIC SOCIETY BULLETIN (2021)

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Article Nanoscience & Nanotechnology

Flexible and Waterproof 2D/1D/0D Construction of MXene-Based Nanocomposites for Electromagnetic Wave Absorption, EMI Shielding, and Photothermal Conversion

Zhen Xiang et al.

Summary: An electrostatic assembly approach was used to fabricate Ti3C2Tx/CNTs/Co nanocomposites, showcasing outstanding electromagnetic wave absorption, EMI shielding, and photothermal conversion performance, making them highly promising for the next-generation intelligent electromagnetic attenuation system.

NANO-MICRO LETTERS (2021)

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Review Chemistry, Multidisciplinary

Haemostatic materials for wound healing applications

Baolin Guo et al.

Summary: Wounds are a common health issue, and the cost of wound care and healing has been increasing. Hemostasis is the first step in wound healing, and various forms and components of hemostatic materials have been developed. Future directions in the development of hemostatic materials focus on addressing challenges in wound healing.

NATURE REVIEWS CHEMISTRY (2021)

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Article Engineering, Chemical

A cost-effective approach to synthesize NiFe2O4/MXene heterostructures for enhanced photodegradation performance and anti-bacterial activity

Tabinda Rasheed et al.

Summary: A cost-effective ultrasonication approach was employed to synthesize NiFe2O4/MXene heterostructures, which demonstrated outstanding photodegradation performance and antibacterial activity compared to individual NiFe2O4 (NiFe) or MXene. The introduced photocatalyst NiFe/MXene heterostructures showed significantly enhanced degradation of organic pollutants and antibacterial activity against E-coli bacteria. The research contributes significantly to the field of water desalination for young researchers.

ADVANCED POWDER TECHNOLOGY (2021)

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Review Multidisciplinary Sciences

The world of two-dimensional carbides and nitrides (MXenes)

Armin Vahid Mohammadi et al.

Summary: MXenes, a family of two-dimensional materials, have diverse properties and wide-ranging applications in areas such as optics, catalysis, sensing, and medicine. Future research directions will focus on deepening the fundamental understanding of MXenes properties and exploring their potential for hybridization with other 2D materials.

SCIENCE (2021)

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Article Materials Science, Multidisciplinary

MXenes and MXene-based materials for tissue engineering and regenerative medicine: recent advances

Siavash Iravani et al.

Summary: The paper discusses the significant role of 2D MXenes in the field of biomedical research, especially in tissue engineering and regenerative medicine. Despite their promising potential, challenges such as stability in physiological environments and controlled drug release need to be addressed for MXenes to be effectively utilized in various biomedical applications.

MATERIALS ADVANCES (2021)

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Article Materials Science, Biomaterials

Moderating cellular inflammation using 2-dimensional titanium carbide MXene and graphene variants

Tochukwu Ozulumba et al.

Summary: This study compares the physiological interactions of titanium carbide MXene and graphene variants with biological systems, showing no significant impact on cell metabolism or induction of inflammatory pathways leading to cell death. While these nanomaterials exhibit minimal antibacterial activity toward E. coli, they significantly reduce bacterial endotoxin-induced inflammatory cytokine production, suggesting their potential utility as adsorbents in medical device applications.

BIOMATERIALS SCIENCE (2021)

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Review Chemistry, Multidisciplinary

Chemistry of two-dimensional MXene nanosheets in theranostic nanomedicine

Yuemei Wang et al.

CHINESE CHEMICAL LETTERS (2020)

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Article Chemistry, Multidisciplinary

2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction

Shanshan Pan et al.

ADVANCED SCIENCE (2020)

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Article Microbiology

A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques

Jonathan T. Su et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

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Review Materials Science, Ceramics

Advancements in MXene-Polymer composites for various biomedical applications

Suchi Mercy George et al.

CERAMICS INTERNATIONAL (2020)

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Review Biochemistry & Molecular Biology

Scars or Regeneration?-Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses

Dongsheng Jiang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Multidisciplinary

Engineering 2D Mesoporous Silica@MXene-Integrated 3D-Printing Scaffolds for Combinatory Osteosarcoma Therapy and NO-Augmented Bone Regeneration

Qianhao Yang et al.

SMALL (2020)

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Article Chemistry, Multidisciplinary

Beyond Ti3C2Tx: MXenes for Electromagnetic Interference Shielding

Meikang Han et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Nonoxidized MXene Quantum Dots Prepared by Microexplosion Method for Cancer Catalytic Therapy

Xuesong Li et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Insights into the Photothermal Conversion of 2D MXene Nanomaterials: Synthesis, Mechanism, and Applications

Dingxin Xu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Materials Science, Multidisciplinary

MXene-based photocatalysts

Panyong Kuang et al.

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2020)

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Review Chemistry, Physical

Current Trends in MXene-Based Nanomaterials for Energy Storage and Conversion System: A Mini Review

Karthik Kannan et al.

CATALYSTS (2020)

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Article Engineering, Chemical

Ultrasensitive Ti3C2TXMXene/Chitosan Nanocomposite-Based Amperometric Biosensor for Detection of Potential Prostate Cancer Marker in Urine Samples

Stefania Hroncekova et al.

PROCESSES (2020)

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Article Nanoscience & Nanotechnology

Highly Efficient Photothermal Conversion of Ti3C2Tx/Ionic Liquid Gel Pen Ink for Smoothly Writing Ultrasensitive, Wide-Range Detecting, and Flexible Thermal Sensors

Haoge Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Unique cellular network formation guided by heterostructures based on reduced graphene oxide - Ti3C2Tx MXene hydrogels

Jacek K. Wychowaniec et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Multidisciplinary

Advanced Theragenerative Biomaterials with Therapeutic and Regeneration Multifunctionality

Baoding Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Nanoscience & Nanotechnology

Materials design for bone-tissue engineering

Gerry L. Koons et al.

NATURE REVIEWS MATERIALS (2020)

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Article Materials Science, Multidisciplinary

Mesoporous bioactive glass for synergistic therapy of tumor and regeneration of bone tissue

Yaqin Liu et al.

APPLIED MATERIALS TODAY (2020)

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Article Nanoscience & Nanotechnology

MXene-Based Hydrogels Endow Polyetheretherketone with Effective Osteogenicity and Combined Treatment of Osteosarcoma and Bacterial Infection

Jie Yin et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation

Lin Mao et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Review Oncology

Regenerative Wound Dressings for Skin Cancer

Teodor Iulian Pavel et al.

CANCERS (2020)

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Review Chemistry, Multidisciplinary

MXene hydrogels: fundamentals and applications

Yi-Zhou Zhang et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

A near-infrared light-mediated antimicrobial based on Ag/Ti3C2Txfor effective synergetic antibacterial applications

Xiaoquan Zhu et al.

NANOSCALE (2020)

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Article Medicine, Research & Experimental

Mussel-inspired conductive Ti2C-cryogel promotes functional maturation of cardiomyocytes and enhances repair of myocardial infarction

Genlan Ye et al.

THERANOSTICS (2020)

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