4.8 Article

Biomodified Extracellular Vesicles Remodel the Intestinal Microenvironment to Overcome Radiation Enteritis

期刊

ACS NANO
卷 17, 期 14, 页码 14079-14098

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.3c04578

关键词

extracellular vesicles (EVs); exosomes; microRNAs; ionizing radiation (IR); intestines; enteritis

向作者/读者索取更多资源

This study found that exosomes derived from mice exposed to total body irradiation can protect recipient mice against radiation-induced gut injury. MiR-142, highly expressed in exosomes, plays a key role in mediating the protective effect against radiation enteritis by improving the intestinal microenvironment. Biomodification of exosomes through enhancing miR-142 expression and intestinal specificity can further improve the protection against radiation enteritis.
Ionizingradiation (IR) is associated with the occurrence of enteritis,and protecting the whole intestine from radiation-induced gut injuryremains an unmet clinical need. Circulating extracellular vesicles(EVs) are proven to be vital factors in the establishment of tissueand cell microenvironments. In this study, we aimed to investigatea radioprotective strategy mediated by small EVs (exosomes) in thecontext of irradiation-induced intestinal injury. We found that exosomesderived from donor mice exposed to total body irradiation (TBI) couldprotect recipient mice against TBI-induced lethality and alleviateradiation-induced gastrointestinal (GI) tract toxicity. To enhancethe protective effect of EVs, profilings of mouse and human exosomalmicroRNAs (miRNAs) were performed to identify the functional moleculein exosomes. We found that miRNA-142-5p was highly expressed in exosomesfrom both donor mice exposed to TBI and patients after radiotherapy(RT). Moreover, miR-142 protected intestinal epithelial cells fromirradiation-induced apoptosis and death and mediated EV protectionagainst radiation enteritis by ameliorating the intestinal microenvironment.Then, biomodification of EVs was accomplished via enhancing miR-142expression and intestinal specificity of exosomes, and thus improvedEV-mediated protection from radiation enteritis. Our findings providean effective approach for protecting against GI syndrome in peopleexposed to irradiation.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据