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Article
Chemistry, Multidisciplinary
Haoyang Xu et al.
Summary: This study investigates nitrogen-doped Ti3C2 MXene (N-Ti3C2(H)) prepared via hydrothermal method as an efficient catalyst for lithium-oxygen (Li-O-2) battery. The nitrogen doping increases the disorder degree of the material, provides abundant active sites, and promotes electron exchange, leading to improved battery performance.
Article
Chemistry, Multidisciplinary
Qiqing Chen et al.
Summary: The authors engineered a single copper atom-doped titanium dioxide nanosonosensitizer for synergistic chemodynamic and sonodynamic treatment of triple-negative breast cancer (TNBC). The nanosonosensitizers effectively inhibited TNBC both in vitro and in vivo, providing a therapeutic paradigm for non-invasive and safe tumor elimination using multifunctional single-atom nanosonosensitizers.
Review
Chemistry, Multidisciplinary
Xukai Wang et al.
Summary: Osteomyelitis is a refractory disease in orthopedics caused by infection with pathogenic microorganisms. Antibacterial therapy, in addition to surgical debridement, is currently the main approach for treating osteomyelitis. However, traditional antibiotics are facing bacterial resistance, prompting the development of advanced antibacterial agents. This review discusses the main targets and mechanisms of antibacterial agents for osteomyelitis treatment, as well as their potential clinical applications.
Article
Chemistry, Multidisciplinary
Lihua Wu et al.
Summary: A biomimetic nanozyme catalyst with rapid and efficient self-bacteria-killing and wound-healing performances was synthesized. It exhibited excellent antibacterial properties against Staphylococcus aureus by capturing surrounding oxygen species to produce radical oxygen species. Additionally, it promoted wound healing by upregulating fibroblast proliferation and angiogenesis genes.
Article
Chemistry, Multidisciplinary
Xiangdan Meng et al.
Summary: In this study, we report the design of a Ti-based metal-organic framework (MIL) and silver nanoparticles (Ag NPs) heterostructure, MIL@Ag. It is found that the introduction of Ag NPs significantly improves the electron transfer efficiency and O2 adsorption capacity of MIL, leading to enhanced reactive oxygen species (ROS) generation for sonodynamic therapy (SDT). Under ultrasound irradiation, the activated electrons and holes from MIL and Ag NPs produce superoxide radicals and hydroxyl radicals, respectively, improving the therapeutic efficiency of SDT. MIL@Ag-PEG-mediated SDT demonstrates effective cancer cell killing and bacterial infection eradication. Thus, MIL@Ag-PEG provides a promising strategy for enhancing SDT performance through rational heterostructure design of sonosensitizers.
Article
Chemistry, Multidisciplinary
Congyang Mao et al.
Summary: Confering catalytic defects in sonosensitizers is crucial for enhancing sonodynamic therapy. In this study, 2D catalytic planar defects were designed within Ti3C2 sheets to overcome this challenge. These planar slip dislocations with abundant Ti3+ species can activate O-2, resulting in a significant amount of O-1(2) generation and a high bactericidal capability under ultrasound stimulation. It was found that the 2D catalytic planar defects can intervene in electron transfer through the phonon drag effect, leading to a dramatic decrease in O-2 activation energy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jianfang Li et al.
Summary: A rapid and effective therapeutic strategy for treating osteomyelitis is reported, utilizing ferroelectric polarization interfacial engineering of BiFeO3/MXene (Ti3C2) triggered by ultrasound. The ferroelectric polarization induced by ultrasound leads to the formation of a piezoelectric field, and the sonoluminescence effect stimulates BiFeO3/Ti3C2 to produce photogenerated carriers. With the synergistic action of the polarization electric field and Schottky junction, the separation of electrons and holes is accelerated, improving the utilization of polarized charges and photogenerated charges, and enhancing the yield of reactive oxygen species. This approach efficiently kills Staphylococcus aureus in a short time with the assistance of ultrasonic heating.
ADVANCED MATERIALS
(2023)
Article
Engineering, Environmental
Junjie Wu et al.
Summary: In this study, a composite nano-generator, CaO2@ZIF-67-PLL, was developed for the rapid therapy of biofilm-infected wounds. The CaO2@ZIF-67-PLL exhibited strong anti-biofilm capability against Escherichia coli and Staphylococcus aureus. Moreover, it promoted the healing process of Staphylococcus aureus-infected wounds by suppressing inflammatory responses, enhancing collagen disposition and angiogenesis, and stimulating signaling pathways.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Minxian Cheng et al.
Summary: Nitrogen and phosphorus co-doped porous carbons were synthesized and their excellent degradation ability to tetracycline was observed. Electron transfer mediated by metastable reactive complexes and singlet oxygen played a key role in the degradation process. The introduction of phosphorus promoted the adsorption and activation of peroxydisulfate, leading to high-efficiency removal of contaminants.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Medicine, General & Internal
Christopher J. L. Murray et al.
Summary: Antimicrobial resistance (AMR) poses a significant threat to global human health, and this study provides the most comprehensive estimates of AMR burden to date. By estimating deaths and disability-adjusted life-years (DALYs) associated with bacterial AMR in 204 countries and territories in 2019, the study highlights the impact of resistance and the leading pathogen-drug combinations contributing to it.
Review
Microbiology
Elysia A. Masters et al.
Summary: This review explores the microbial pathogenesis, immunity, and clinical management of bone infections, highlighting osteomyelitis as a significant risk in orthopaedic surgery. It discusses the mechanisms of persistence and immune evasion in Staphylococcus aureus infection of the skeletal system, as well as features of other osteomyelitis-causing pathogens. The article also describes the clinical management of skeletal infection, including osteomyelitis classification and strategies for treating skeletal infections with emerging technologies.
NATURE REVIEWS MICROBIOLOGY
(2022)
Review
Microbiology
D. G. Joakim Larsson et al.
Summary: Antibiotic resistance is a global health challenge, with factors driving evolution and transmission being important to quantify and identify. The environment plays a crucial role, and understanding and managing the resistance crisis can be achieved through implementing monitoring and assessment methods to reduce risks.
NATURE REVIEWS MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Fan Zhuang et al.
Summary: The study developed a sequential ultrasound/hypoxia-sensitive sonochemotherapeutic nanoprodrug that combines hypoxic condition with sonodynamic therapy to enhance the treatment outcome of tumors.
Article
Chemistry, Multidisciplinary
Min Zhang et al.
Summary: This study reports the fabrication of two-dimensional (2D) nanosonosensitizers/nanocatalysts for in situ generation of nanosonosensitizers, which respond to the tumor microenvironment. The nanosonosensitizers showed enhanced sonodynamic therapy (SDT) efficacy due to in situ generation of TiO2 nanosonosensitizers and enhanced ROS production. The combination of SDT and chemodynamic therapy demonstrated synergistic therapeutic effects both in vitro and in vivo.
Article
Chemistry, Multidisciplinary
Congyang Mao et al.
Summary: Multidrug-resistant (MDR) bacteria pose an urgent threat to global public health. This study found that the antibiotic resistance mechanisms in MDR Escherichia coli can be compromised and the bacteria become sensitive to conventional antibiotics when the temperature of infected tissues is elevated. Microwave-driven hyperthermia therapy disrupts various resistance mechanisms and enhances the bactericidal effects of traditional antibiotics.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Hao Cheng et al.
Summary: Light-assisted antibacterial therapy, especially using visible light, has shown great potential as an alternative to antibiotic therapy. Recent research has focused on using near-infrared light irradiation to kill bacteria through hyperthermia and radical oxygen species. However, this study presents a visible light responsive organic-inorganic hybrid material for efficient treatment of bacterial infection. By capturing bacteria electrostatically and utilizing visible light through a Schottky junction, the material exhibits excellent antibacterial properties both in vitro and in vivo. This research highlights the potential of organic-inorganic materials in bio-photocatalysis and antibiotics-free treatment of wounds.
Article
Chemistry, Multidisciplinary
Yunchao Zhao et al.
Summary: This study demonstrates the use of a Cu2-xO-BaTiO3 piezoelectric heterostructure as a sonosensitizer and chemodynamic agent for enhanced cancer therapy through ultrasound irradiation.
Article
Chemistry, Multidisciplinary
Hua-Jie Niu et al.
Summary: Heterointerfaces can adjust the adsorption energy and decrease the kinetics energy barrier. The interface between NiCoP and MXene effectively reduces the energy barrier for alkaline hydrogen evolution reaction (HER) by 16.0-22.1%. In addition, the photothermal effect of MXenes can raise the catalyst temperature for energy savings.
Article
Multidisciplinary Sciences
Yin Qin et al.
Summary: This study demonstrates an effective strategy to enhance the activity and stability of RuO2 catalyst for acidic oxygen evolution reaction by electrochemical lithium intercalation.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yangkai Zhou et al.
Summary: This study developed defective tungsten oxide nanobelts (WOx NBs) as pH-sensitive and biodegradable sonosensitizers to improve the efficiency and biodegradability in sonodynamic therapy (SDT). WOx NBs could generate abundant reactive oxygen species (ROS) under ultrasound (US) irradiation and degrade slowly in an acidic environment, reducing long-term toxicity.
Article
Chemistry, Multidisciplinary
Yuan Li et al.
Summary: This study presents a new NIR light catalyst that enhances the sensitivity of bacteria to reactive oxygen species and heat, resulting in the effective killing of bacteria under mild conditions. The catalyst alters bacterial metabolic processes and disrupts protein structures, exhibiting synergistic antibacterial effects with clinical antibiotics. Additionally, the catalyst stimulates immune responses and reduces complications.
Article
Chemistry, Multidisciplinary
Yijie Cheng et al.
Summary: This study presents an activatable nanostructure for synergistic sonodynamic-catalytic therapy of MRSA-infected osteomyelitis. The nanostructure effectively kills bacteria and promotes inflammation resolution and bone cell proliferation, showing promising potential for osteomyelitis treatment.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yecan Pan et al.
Summary: Cellular oxidative stress caused by reactive oxygen species (ROS) and its induced molecular response is crucial in the development of various diseases and biological processes. By using DNA nanostructure-based fluorescent probes, the localization and abundance of ROS and its related molecules can be simultaneously mapped in living cells. This study introduces intramolecular Orthogonal Reporters (iOR) based on DNA nanostructure scaffolds, which eliminate undesired fluorophore interaction by precise positioning of fluorescence reporters. iOR, functionalized with nuclear localization signal peptide, enables high sensitivity and specificity in imaging ROS and its associated DNA repair enzyme (APE1) in the nucleus and cytoplasm. The study reveals a strong positive correlation and synergistic regulation between ROS and APE1 in living cells and tumor-bearing mice through direct fluorescence imaging. This work presents a new approach for developing nanostructure-based molecular probes with broad applications in cellular biology and nanotechnology.
Article
Nanoscience & Nanotechnology
Pawet P. Michalowski et al.
Summary: The MXene family, a type of two-dimensional materials with various compositions, has great potential for applications in energy storage, electronics, and medicine. Through the use of ultralow-energy secondary-ion mass spectrometry, this study provides valuable insights into the composition, layered structure, and interaction between surface termination layers of MXene materials with atomic resolution.
NATURE NANOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Duong Nguyen Nguyen et al.
Summary: The in situ growth of hollow Ni2P nanospheres on defect-engineered MXene shows enhanced catalytic activity and stability for hydrogen evolution reaction. This approach presents significant potential for designing advanced catalysts coupled with 2D materials and transition metal-based compounds.
Article
Multidisciplinary Sciences
Bijiang Geng et al.
Summary: In this study, a new method for designing near infrared (NIR) emitting sonosensitizers is reported. These sonosensitizers have a narrow bandgap and long-lived excited states, which can enhance sonodynamic therapy under low-intensity ultrasound irradiation. By encapsulating the sonosensitizers in cancer cell membranes, precise targeting and complete eradication of solid tumors can be achieved with a single injection and single irradiation.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Huiping Zhu et al.
Summary: In this study, a microwave-responsive MoO2/WO3 heterojunction was developed for the effective treatment of MRSA-infected osteomyelitis. The composite exhibited enhanced MW thermal effect and MW catalysis, resulting in the formation of radical oxygen species and an interfacial electrical field under MW irradiation. These characteristics of MoO2/WO3 hold promise for the treatment of deep-tissue infections.
Article
Chemistry, Multidisciplinary
Le Wang et al.
Summary: The smart dressing can self-monitor the amount of residual nanomedicine in order to evaluate the appropriate time points for the replacement of wound dressings, thus preventing secondary damage to wounds. This novel dressing holds great promise for broad clinical applications.
Article
Chemistry, Multidisciplinary
Xin Wang et al.
Summary: Tensile-strained Mxene/CNT porous microspheres were developed as an electrocatalyst for the lithium polysulfide redox reaction, with internal stress, macroporous framework, and CNT interwoven enhancing their electrochemical performance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Peiran Zhao et al.
Summary: By regulating the electron density of reaction center atoms, this study has successfully increased the catalytic activity of Fe, reduced the activation energy of the Fenton reaction, and increased the (OH)-O- production rate. This provides a new possibility for highly effective chemodynamic therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Xian-liang Zhao et al.
Summary: Exogenous glutamine can enhance the killing effect of antibiotics against multidrug-resistant bacteria, promote the influx of antibiotics, increase intracellular antibiotic concentrations, effectively prevent the development of antibiotic resistance, and provide new insights for the prevention or management of chronic, multidrug-resistant bacterial infections, bacterial persistence, and difficult-to-treat bacterial biofilms.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Brittney D. Gimza et al.
Summary: Staphylococcus aureus is a common etiologic agent in osteomyelitis, a prevalent invasive disease. Treatment of this infection is challenging due to antimicrobial resistant strains, antibiotic tolerance in staphylococci, and bone remodeling and destruction.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Shikun Wei et al.
Summary: This study developed a hydrogel system for the treatment of chronic infected wounds, which can effectively regulate inflammation and enhance collagen deposition and angiogenesis by using antimicrobial peptides and PRP. The hydrogel showed sustained-release capacity, anti-bacterial activity against pathogenic strains, and promoted fibroblast cells proliferation and migration. Additionally, the hydrogel accelerated wound healing in diabetic mouse infection, leading to improved collagen deposition, reduced bacterial load, and balanced inflammatory response.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Shuang Liang et al.
Summary: Researchers have developed a novel sonosensitizer D-MOF(Ti) for enhanced sonodynamic therapy, which exhibits superior ROS yield and Fenton-like activity under ultrasound irradiation. The synergistic outcomes of sonodynamic and chemodynamic therapy have been achieved using ultrasound as the excitation source.
ADVANCED MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Tao Zhang et al.
Summary: The nucleus-targeted ultra-small Ti-TCPP MOF developed in this study represents an effective approach to enhanced SDT treatment of tumors in response to low-intensity US irradiation. This MOF showed promising therapeutic efficacy by inducing cell apoptosis and inhibiting orthotopic pancreatic tumor growth, without apparent toxicity, suggesting its potential for clinical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yi Yu et al.
Summary: This study developed an ultrasound-activated single-atom catalyst for the efficient treatment of MRSA-infected osteomyelitis, showing great significance in the treatment of osteomyelitis.
Article
Chemistry, Multidisciplinary
Shuang Liang et al.
Summary: By engineering platinum and glutathione-modified vanadium tetrasulfide nanodendrites as a new sonosensitizer, the charge lifetime is extended and ROS production activity is significantly increased, leading to efficient tumor suppression.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Marcus Miethke et al.
Summary: There is a growing demand for novel antimicrobials to treat infections caused by multidrug-resistant bacterial pathogens, but there is currently a lack of investment in this field. New agents with innovative chemistry and modes of action are urgently needed to combat the public health threat posed by antimicrobial resistance. The consortium proposes short-term and long-term solutions to overcome urgent limitations in research and funding, aiming to bridge the gap between academic, industrial, and political stakeholders to improve the ability to discover and develop new antibiotics.
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ADVANCED FUNCTIONAL MATERIALS
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NEW ENGLAND JOURNAL OF MEDICINE
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NATURE COMMUNICATIONS
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NATURE COMMUNICATIONS
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CHEMICAL SOCIETY REVIEWS
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Review
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Subin Son et al.
CHEMICAL SOCIETY REVIEWS
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Review
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MATERIALS HORIZONS
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Review
Microbiology
Mike Tyers et al.
NATURE REVIEWS MICROBIOLOGY
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Oncology
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ANNALS OF ONCOLOGY
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NATURE COMMUNICATIONS
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NATURE COMMUNICATIONS
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Oliver Soehnlein et al.
NATURE REVIEWS IMMUNOLOGY
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Review
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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Takeshi Ueno et al.
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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