期刊
ACS APPLIED MATERIALS & INTERFACES
卷 15, 期 44, 页码 50962-50972出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.3c13584
关键词
triple-shape-memory polymers; thermal responsive; light responsive; cytocompatible; smart materials; functional materials
This study reports the design and characterization of a cytocompatible triple-shape memory polymer material that can undergo two distinct shape changes under cytocompatible conditions via thermal and light triggers. The material demonstrated a larger thermal shape change followed by a smaller photothermal shape change, with high cell viability, showing the potential for application in biomedical devices and strategies.
Triple-shape-memory polymers (triple-SMPs) are a class of polymers capable of fixing two temporary shapes and recovering sequentially from the first temporary shape to the second temporary shape and, last, to the permanent shape. To accomplish a sequential shape change, a triple-SMP must have two separate shape-fixing mechanisms triggerable by distinct stimuli. Despite the biomedical potential of triple-SMPs, a triple-SMP that with cells present can undergo two different shape changes via two distinct cytocompatible triggers has not previously been demonstrated. Here, we report the design and characterization of a cytocompatible triple-SMP material that responds separately to thermal and light triggers to undergo two distinct shape changes under cytocompatible conditions. Tandem triggering was achieved via a photothermally triggered component, comprising poly(epsilon-caprolactone) (PCL) fibers with graphene oxide (GO) particles physically attached, embedded in a thermally triggered component, comprising a tert-butyl acrylate-butyl acrylate (tBA-BA) matrix. The material was characterized in terms of thermal properties, surface morphology, shape-memory performance, and cytocompatibility during shape change. Collectively, the results demonstrate cytocompatible triple-shape behavior with a relatively larger thermal shape change (an average of 20.4 +/- 4.2% strain recovered for all PCL-containing groups) followed by a smaller photothermal shape change (an average of 3.5 +/- 0.8% strain recovered for all PCL-GO-containing groups; samples without GO showed no recovery) with greater than 95% cell viability on the triple-SMP materials, establishing the feasibility of triple-shape memory to be incorporated into biomedical devices and strategies.
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