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Article
Multidisciplinary Sciences
Yan Zhou et al.
Summary: The authors propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. This patch eliminates the conventional interface impedance between the electrode and drug reservoir, reducing system complexity and size. The delivery dosage can be easily manipulated by tuning the viologen hydrogel and the iontophoresis stimulation mode.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Fang Niu et al.
Summary: The photocatalytic H-2 evolution reaction is crucial for solar energy storage, and the rate of photogenerated electron transfer is the key step in this process. Viologen derivatives with non-conjugated substituent groups enhance the electron transfer rate, while those with conjugated substituent groups decrease the kinetics of photocatalytic H-2 evolution. Viologen derivatives with non-conjugated substituent groups have a stronger electron capturing ability and can easily be reduced for proton reduction.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Yan Zhou et al.
Summary: We developed a viologen-based conductive hydrogel with multiple dynamic interactions, which has cytocompatibility and antibacterial properties. It forms an intimate bioelectronic interface with skin tissue, exhibiting high ionic conductivity, low contact impedance, high toughness, and seamless adhesion. This hydrogel offers a fast response to electrical signals and high release efficiency at a low voltage. Moreover, it can be used as an integrated drug-carrying electrode in a Mg biobattery powered-iontophoresis device for stable and effective drug release, providing a non-invasive therapeutic approach for chronic skin diseases requiring daily or precise drug delivery.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Didem Aycan et al.
Summary: Recently, a stimuli-responsive hydrogel using hyaluronic acid (HA), reduced graphene oxide (rGO), and polyaniline (PANI) was developed for controlled drug delivery. The hydrogel exhibited electro-responsive ability and was able to release the anti-inflammatory drug, Ibuprofen (IBU), upon electrical stimulation. The inclusion of rGO and PANI improved the mechanical performance of the hydrogel. This novel HA/MA-rGO-PANI hydrogel shows potential for use in electrical-stimulated anti-inflammatory release systems in neural implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Jiaxin Chen et al.
Summary: A novel hydrogel system was developed for gene-cell combination therapy of intervertebral disc degeneration (IVDD). The hydrogel, containing phenylboronic acid-modified G5 PAMAM (G5-PBA) and siRNA silencing the expression of P65, showed local and acidic inflammatory microenvironment-responsive gene-drug release, sustained for more than 28 days in vitro and in vivo. The hydrogel could effectively inhibit the secretion of inflammatory factors and enhance the regeneration of intervertebral discs when combined with cell therapy.
Article
Chemistry, Physical
Heyu Sun et al.
Summary: In this study, a hydrogel with chitosan/sodium alginate/calcium ion physical cross-linked double network structure was prepared using a semi-dissolution acidification sol-gel transition method. Hyperbranched polyamide-amine was introduced to improve the adsorption capacity of the hydrogel. Experimental results showed that the third-generation hyperbranched polyamide-amine hydrogel exhibited the best comprehensive performance, with high adsorption capacities for copper ions and cadmium ions.
APPLIED SURFACE SCIENCE
(2023)
Article
Polymer Science
Jang Ho Ha et al.
Summary: The proposed electro-responsive hydrogel has significant benefits for transdermal drug delivery system (TDDS). Researchers have previously studied blending efficiencies to improve the physical or chemical properties of hydrogels, but few studies have focused on improving electrical conductivity and drug delivery. In this study, a conductive blended hydrogel was developed by mixing alginate with gelatin methacrylate (GelMA) and silver nanowire (AgNW). The blended hydrogel showed increased tensile strength and enhanced electrical conductivity. It also enabled on-off controllable drug release in response to electrical stimulation (ES). This electro-responsive blended hydrogel patch has potential applications in smart drug delivery.
Review
Chemistry, Multidisciplinary
Yongping Liang et al.
Summary: Conductive hydrogels (CHs) have gained extensive attention due to their combination of biomimetic properties of hydrogels and electrochemical properties of conductive materials. They are capable of detecting electrical signals in biological systems and conducting electrical stimulation for cell regulation. This review focuses on their applications in tissue repair, including nerve, muscle, skin, and bone tissue regeneration, showcasing different types of CHs and the mechanisms behind tissue repair promoted by CHs.
Article
Engineering, Multidisciplinary
Minjing Gu et al.
Summary: Due to the lack of blood and nutrition supply, the repairing of cartilage defect has become a challenging topic in clinical treatment. In this study, a unique porous scaffold based on regenerated silk fibroin (RSF) was fabricated, and its properties were improved by combining bacterial cellulose nanofiber ribbon (BCNR). The effects of dynamic hydrostatic pressure (DHP) on tissue engineered cartilage in vitro and dynamic loading microenvironment on cartilage defect regeneration in vivo were comprehensively investigated. The study found that DHP enhanced chondrocyte growth and cartilage specific matrix deposition, and dynamic loading microenvironment significantly improved cartilage regeneration.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Multidisciplinary
Linhua Li et al.
Summary: This study developed a highly efficient and bacteria-responsive silver ion coating with controlled-release properties. The coating showed good antibacterial activity, biocompatibility, and promoted wound healing. Animal experimental results demonstrated that the coating could stop bleeding, inhibit bacterial growth, and accelerate wound healing.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Endris Yibru Hanurry et al.
Summary: In this study, a pH-responsive PAMAM dendritic nanocarrier-incorporated hydrogel for the co-delivery of immunochemotherapeutic drugs was constructed. Experimental results showed that the hydrogel exhibited sustained drug release, enhanced cellular uptake, and induced apoptosis. Local injection of the formulation into mice significantly suppressed tumor growth, induced an immune response, and had no obvious systemic toxicity. This method could be a promising strategy to enhance antitumor activity in cancer therapy.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Quanduo Liang et al.
Summary: This study utilizes microgels as large crosslinking centers in hydrogel networks to produce hydrogels that closely match the chemomechanical properties of neural tissues. These hydrogels exhibit low modulus, good stretchability, and outstanding fatigue resistance, making them suitable for wearable and implantable sensors. The hydrogels can obtain physiological signals and be successfully implanted in rats for a long-term period. This work contributes to a deeper understanding of biohybrid interfaces and advances the design concepts for implantable neural probes that efficiently obtain physiological information.
Article
Engineering, Biomedical
Jiaxin Chen et al.
Summary: A novel siSTING delivery hydrogel was constructed to intervene the abnormal STING signal for intervertebral disc degeneration treatment, effectively silencing STING expression in NP cells and significantly easing IVD inflammation and slowing IVD degeneration by prolonging STING knockdown in a rat model. This revealed the therapeutic potential of targeting the STING pathway for IVD degeneration and the broader application of such innovative hydrogel for gene delivery in various diseases.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Multidisciplinary
Di Wang et al.
Summary: A novel fiber reinforced organohydrogel with excellent mechanical properties, ionic conductivity, and low-temperature tolerance has been developed for practical applications. It also shows promising potential as a wearable strain sensor with high sensitivity, stability, and repeatability.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Multidisciplinary
Narsimha Mamidi et al.
Summary: In the past decade, nanotechnology has rapidly advanced disease diagnosis and therapy, particularly with the use of carbonaceous nanomaterials (CNMs) to enhance biomaterials. CNMs offer outstanding properties such as electrical conductivity, mechanical strength, and a high surface area, making them ideal for applications in orthopedics, bioimaging, and wearable biosensors. This review discusses the recent progress and future trends of CNMs integrated with biomaterials in biomedical applications.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Polymer Science
Jiaxin Zhao et al.
Summary: This study reports a multi-stimuli-responsive color/fluorescence dual-switching polymer material, which can undergo conformation change, reversible aggregation/de-aggregation, and molecular structure transition under various environmental stimuli. This material has potential applications in the field of sensors, controlled drug release, and intelligent devices.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Engineering, Biomedical
Yazhen Li et al.
Summary: In this study, a polydopamine-mediated graphene oxide and hydroxyapatite nanoparticle-incorporated conductive scaffold was developed to accelerate periodontal bone regeneration in diabetic patients. The scaffold demonstrated conductivity, ROS-scavenging, anti-inflammatory, and immunomodulatory abilities, leading to excellent bone regeneration by modulating macrophage functions.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Yaqi Zhang et al.
Summary: In this study, conductive, injectable, and biocompatible hydrogels were used to develop self-powered electrically responsive and wearable/implantable drug delivery systems. The hydrogels exhibited high conductivity and good stretchability, making them suitable for bioelectrodes and wearable/implantable drug carriers. Additionally, a self-powered triboelectric nanogenerator was fabricated using the hydrogels as a triboelectric material.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Biochemical Research Methods
Juan Wang et al.
Summary: This article provides an overview of the history and properties of dendrimers, as well as the latest developments in their applications as drug delivery systems. The review focuses on active drug release strategies, size-adaptive and charge reversal dendrimer delivery systems, and bulk and micro/nano dendrimer gel delivery systems.
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Jiang Zhan et al.
Summary: In this study, composite gels containing sodium alginate/chitosan were prepared with the introduction of chitosan on polyamidoamine. The SCPP-G2 composite gel showed higher stability and greater adsorption capacity for dyes. Chemical adsorption was found to be the dominant mechanism for dye adsorption.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Dingxuan Wang et al.
Summary: This study successfully promoted the self-healing speed of alginate hydrogels by introducing a dendritic structure, demonstrating the stability and antibacterial properties of the novel hydrogel in experimental results.
Article
Engineering, Multidisciplinary
Dharneedar Ravichandran et al.
Summary: Smart materials and structures with shape memory properties have attracted attention due to their unique abilities. This research presents a new 3D printing process using the MDIW mechanism to produce microlayers. The selective deposition of different materials is investigated for thermal and magnetic stimuli-responsiveness. The study provides insights into controlling actuation phenomena for broad applications.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Jing Zhou et al.
Summary: The combination of CB[7] with BPV2(2+) resulted in enhanced fluorescence emission intensity and better biocompatibility of the host-guest complexes, suggesting potential applications in fluorescent probes and biological imaging.
CHINESE CHEMICAL LETTERS
(2021)
Article
Polymer Science
Xiaowen Huang et al.
Summary: This paper introduces a self-healing hydrogel suitable for complex natural environments, incorporating disulfide bonds, acylhydrazone bonds, and hydrogen bonds. The experiment demonstrates that the hydrogel can self-heal in different environments, with the self-healing efficiency increasing over time.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Lu Liu et al.
Summary: The new AN-POP, incorporating anthracene-extended viologen, showed superior photocatalytic oxidation performance and antibacterial activity compared to its anthracene-free counterpart BD-POP, highlighting the critical role of the anthracene-extended viologen structure.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Xiao-He Zhou et al.
CHINESE CHEMICAL LETTERS
(2020)
Article
Engineering, Chemical
Peipei Tao et al.
JOURNAL OF MEMBRANE SCIENCE
(2020)
Review
Chemistry, Multidisciplinary
Valeria Nele et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Engineering, Multidisciplinary
Qinhua Wang et al.
COMPOSITES PART B-ENGINEERING
(2020)
Article
Chemistry, Applied
Berta Diez et al.
REACTIVE & FUNCTIONAL POLYMERS
(2020)
Article
Multidisciplinary Sciences
Samantha M. Grist et al.
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Analytical
Xin Jing et al.
SENSORS AND ACTUATORS B-CHEMICAL
(2019)
Review
Chemistry, Inorganic & Nuclear
Jian-Ke Sun et al.
COORDINATION CHEMISTRY REVIEWS
(2019)
Article
Engineering, Biomedical
Jin Qu et al.
ACTA BIOMATERIALIA
(2018)
Article
Polymer Science
Malgorzata Konopka et al.
Article
Multidisciplinary Sciences
Hyunwoo Yuk et al.
NATURE COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Wen Yang et al.
Article
Optics
Sibdas Singha Mahapatra et al.
JOURNAL OF LUMINESCENCE
(2008)
Article
Engineering, Biomedical
ZL Shi et al.
