期刊
ACS APPLIED MATERIALS & INTERFACES
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.3c06902
关键词
shape memory; bone defect repair; 4D printing; bioactive; tissue engineering
In this study, a bioactive and shape memory bone scaffold was fabricated using a four-dimensional fused deposition modeling technique. The scaffold utilized a poly(e-caprolactone) segment with a transition temperature near body temperature as the molecular switch for shape memory effect, and a poly(propylene fumarate) segment for improving regulation effect on osteogenesis. The experimental results demonstrated that the scaffold could quickly adapt to defect geometry through shape change, and significantly promote bone regeneration.
Bone tissue engineering involving scaffolds is recognized as the ideal approach for bone defect repair. However, scaffold materials exhibit several limitations, such as low bioactivity, less osseointegration, and poor processability, for developing bone tissue engineering. Herein, a bioactive and shape memory bone scaffold was fabricated using the biodegradable polyester copolymer's four-dimensional fused deposition modeling. The poly(e-caprolactone) segment with a transition temperature near body temperature was selected as the molecular switch to realize the shape memory effect. Another copolymer segment, i.e., poly(propylene fumarate), was introduced for post-cross-linking and improving the regulation effect of the resulting bioadaptable scaffold on osteogenesis. To mimic the porous structures and mechanical properties of the native spongy bone, the pore size of the printed scaffold was set as similar to 300 mu m, and a comparable compression modulus was achieved after photo-cross-linking. Compared with the pristine poly(e-caprolactone), the scaffold made from fumarate-functionalized copolymer considerably enhanced the adhesion and osteogenic differentiation of MC3T3-E1 cells in vitro. In vivo experiments indicated that the bioactive shape memory scaffold could quickly adapt to the defect geometry during implantation via shape change, and bone regeneration at the defect site was remarkably promoted, providing a promising strategy to treat bone defects in the clinic, substantial bone defects with irregular geometry.
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