期刊
ACS APPLIED MATERIALS & INTERFACES
卷 15, 期 42, 页码 49329-49337出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.3c06866
关键词
synaptic devices; MoO3; dopamine; neurotransmitters; biosensors
This study demonstrates a simple, label-free biosensor based on molybdenum oxide for emulating tunable synaptic weight. By initiating a charge transfer mechanism through dopamine oxidation, the channel's conductance is altered, allowing operation in wide ranges of dopamine concentration.
Field-effect transistor-based biosensors have gained increasing interest due to their reactive surface to external stimuli and the adaptive feedback required for advanced sensing platforms in biohybrid neural interfaces. However, complex probing methods for surface functionalization remain a challenge that limits the industrial implementation of such devices. Herein, a simple, label-free biosensor based on molybdenum oxide (MoO3) with dopamine-regulated plasticity is demonstrated. Dopamine oxidation facilitated locally at the channel surface initiates a charge transfer mechanism between the molecule and the oxide, altering the channel conductance and successfully emulating the tunable synaptic weight by neurotransmitter activity. The oxygen level of the channel is shown to heavily affect the device's electrochemical properties, shifting from a nonreactive metallic characteristic to highly responsive semiconducting behavior. Controllable responsivity is achieved by optimizing the channel's dimension, which allows the devices to operate in wide ranges of dopamine concentration, from 100 nM to sub-mM levels, with excellent selectivity compared with K+, Na+, and Ca2+.
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