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Article
Biochemistry & Molecular Biology
Guangye Ge et al.
Summary: Photodynamic therapy (PDT) or chemodynamic therapy (CDT) based on reactive oxygen species (ROS) have been recognized for their low susceptibility to microbial resistance. However, traditional ROS treatment couldn't achieve satisfactory wound healing due to the complex biofilm structure and high quenching rate. Therefore, researchers developed Na2S2O8@ZIF-67/GOx nanoparticles as a high-toxic ROS nanogenerator for biofilm-infecting wound healing, utilizing glucose oxidase (GOx) for amplified CDT and immune activation. The NZG NPs released high-toxic ROS within the biofilm, inhibiting bacterial and biofilm proliferation and promoting immune system activation, ultimately achieving effective wound healing without bacterial tolerance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Physics, Applied
Meimei Fu et al.
Review
Pharmacology & Pharmacy
Gaofeng Wang et al.
Summary: With the development of society and the improvement of life quality, over 500 million people are affected by diabetes. More than 10% of diabetes patients suffer from diabetic wounds, and 80% of these wounds reoccur, highlighting the importance of developing new diabetic wound treatments. Skin microbe research has shed light on the complex relationship between microbes and diabetic wounds. Understanding the skin microbe composition in diabetic wounds can provide valuable guidance for clinical treatment and even lead to potential therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Engineering, Biomedical
Yanan Zhao et al.
Summary: This study presents a comprehensive strategy to remodel the harsh hypoxic microenvironment of diabetic wound healing using NIR-assisted oxygen delivery and the bioactive properties of biopolymers. The strategy involves the self-assembly of black phosphorus nanosheets and hemoglobin onto electrospun nanofibers, utilizing charged quaternized chitosan and hyaluronic acid. The composite wound dressings fabricated through this strategy showed great potential in diabetic wound healing and expanding biomedical engineering fields.
Article
Chemistry, Physical
Xiaoqiong Huang et al.
Summary: Treatment for chronic diabetic wounds remains a clinical challenge. A multifunctional hydrogel with two-stage sequential release upon NIR stimulation, antibacterial activity and pro-angiogenic efficacy has been developed. This hydrogel consists of covalently crosslinked bilayer structure with peptide-functionalized gold nanorods embedded in each layer.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Huiling Zhong et al.
Summary: A novel wound dressing based on near-field electrospinning and modified GelMA hydrogel was developed to promote the healing of diabetic wounds. The dressing had angiogenic and antioxidant properties and encapsulated a slow-release drug, making it suitable for chronic wounds.
Article
Chemistry, Multidisciplinary
Ya-Jun Fu et al.
Summary: Macrophages in diabetic wounds can be divided into pro-inflammatory M1 and anti-inflammatory M2 types. Hydrogel dressings with the ability to regulate macrophage heterogeneity show potential in promoting diabetic wound healing. An all-natural hydrogel has been developed, which can convert M1 macrophages into M2 macrophages without additional ingredients or external intervention, providing a simple and safe approach for accelerating wound healing.
Article
Nanoscience & Nanotechnology
Erman Zhao et al.
Summary: Oxygen plays a crucial role in diabetic chronic wound healing, and oxygen-delivering systems have gained significant attention. This study proposes using an active Chlorella vulgaris (Cv)-loaded separable microneedle (MN) as a method for controlled oxygen delivery to promote wound healing. The Cv-loaded microneedles (CvMN) consist of a PVA substrate and GelMA tips encapsulating Cv, which produces oxygen through photosynthesis and releases it in a controlled manner. Both in vitro and in vivo results demonstrate that CvMN effectively promotes cell proliferation, migration, angiogenesis, and wound healing in diabetic mice. The continuous generation of dissolved oxygen in CvMN and the presence of antioxidative substances in Cv contribute to its remarkable therapeutic effect.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Weiwei Tan et al.
Summary: Diabetic chronic wound healing is a clinical challenge due to disorders in the healing processes caused by persistent inflammation, microbial infection, and impaired angiogenesis. In this study, dual-drug loaded nanocomposite polysaccharide-based self-healing hydrogels were developed to promote diabetic wound healing. The hydrogels exhibited good physical properties and various functions, including tissue adhesiveness, compression strength, self-recovery capacity, hemostatic ability, and antibacterial activity. The hydrogels released metformin rapidly and curcumin sustainedly, showing potential in scavenging free radicals and accelerating wound healing. Overall, the multifunctional synergy of the hydrogels greatly contributed to diabetic wound healing, showing promising application in regenerative medicine.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Biomedical
Yue Zhang et al.
Summary: Chronic diabetic wounds are a globally recognized clinical challenge, and this study found that using exosome-based bioactive dressings as an alternative method for diabetic wound healing has great potential. However, research on multifunctional hydrogels loaded with drugs and bioactive substances that synergistically promote wound repair is lacking, and the mechanism of their combinatorial effect remains unclear.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Ken-ichiro Matsumoto et al.
Summary: The linear density of X-ray-induced dense hydroxyl radicals (center dot OH) in water was estimated using EPR spin-trapping measurement. The yield of DMPO-OH in different concentrations of DMPO water solutions and the total spin-adduct of DMPO in neat DMPO liquid were quantified. The linear density of center dot OH generation in water by X-ray irradiation was estimated based on the inflection point on the plot of DMPO-OH yield versus DMPO linear density.
Article
Chemistry, Multidisciplinary
Huanhuan Chen et al.
Summary: The hydrogen-producing hydrogel made of living Chlorella and bacteria within a cell-impermeable casing can continuously produce hydrogen for 60 hours, selectively reduce highly toxic ·OH and ONOO- species, and reduce inflammation. Studies have shown that the microbe-hydrogel dressing can promote cell proliferation and diabetic wound healing by almost 50% at day 3. This symbiotic algae-bacteria hydrogel demonstrates excellent biocompatibility and reactive oxygen species scavenging capabilities, suggesting great promise for clinical use.
Article
Engineering, Biomedical
Zhaoyuan Guo et al.
Summary: In this study, a composite antibacterial hydrogel PDA-PAM/Mg2+ was developed for accelerated wound healing. This hydrogel showed excellent self-healing and tissue adhesive properties, as well as photothermal antibacterial functions. It demonstrated efficient bacteria inhibition and enhanced wound healing in a rat model.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Jiaxin Yang et al.
Summary: In this study, a glucose-responsive multifunctional metal-organic drug-loaded hydrogel (DG@Gel) was designed for diabetic wound healing. The hydrogel changed the hyperglycemic wound microenvironment, exhibited antibacterial and angiogenic activity, and showed good biocompatibility and biodegradability in vivo.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Zhongqiang Zhu et al.
Summary: A double-layered hydrogel has been developed for the treatment of refractory keratitis and diabetic foot ulcers caused by bacterial infections. The hydrogel can visualize bacterial infections and supply oxygen to enhance antimicrobial photodynamic therapy and alleviate inflammation, promoting wound healing.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Engineering, Environmental
Shumin Zhang et al.
Summary: Reactive oxygen species (ROS) have been demonstrated to be effective against bacterial infections. Inspired by the biocatalytic ability of nanozymes in regulating ROS levels, a hollow mesoporous nanocatalyst with multienzyme-mimicking activity was developed. The nanocatalyst can catalyze glucose into highly reactive hydrogen radicals, resulting in remarkable antibacterial ability. A novel antibacterial wound dressing was fabricated by assembling the nanocatalyst on bacterial cellulose enveloped polypropylene composites, which showed outstanding moisture retention ability and breathability, as well as remarkable biocompatibility and bacteria inactivation ability. In vivo studies demonstrated that the wound dressing can effectively promote wound healing caused by bacterial infections.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Mengnan Chai et al.
Summary: In this study, a flexible porous film based on PVDF-HFP was prepared and its piezoelectric catalysis performance was enhanced using α-Fe2O3 nanoparticles. The α-Fe2O3 nanoparticles not only improved the piezoelectric properties of the film but also provided Fe3+ to participate in the Fenton reaction with H2O2 generated by the film itself. Meanwhile, the Fenton reaction was accelerated by the piezoelectric field, leading to an improved degradation efficiency.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Lei Chen et al.
Summary: This study constructed a nanosupramolecular cascade reactor through the cooperative interaction of multiple noncovalent bonds. The reactor generates hydroxyl radicals under glucose activation, forming hydrogel network structures and inhibiting resistant bacterial infection. The experimental results confirmed the importance of this method in the treatment of diabetic wounds.
Article
Engineering, Biomedical
Shuang Xie et al.
Summary: This study developed self-propelled nanomotors for the treatment of diabetic foot ulcers. The nanomotors released nitric oxide in the biofilm microenvironment to effectively kill bacteria and stimulate angiogenesis. Experimental results demonstrated that the treatment with nanomotors successfully eliminated bacterial infections and promoted wound healing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Zhenghao Wang et al.
Summary: A shape-adaptable, biodegradable, biocompatible interleukin-33 (IL-33)-cytogel has been developed by encapsulating IL-33 into physically cross-linked DNA hydrogels for promoting diabetic wound healing. The IL-33-cytogel releases IL-33 into the wound area for at least 7 days, inducing the accumulation of specific cells and promoting the transition of cells for improved inflammation resolution and wound healing.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Ye Wang et al.
Summary: In this study, an injectable zwitterionic hydrogel with excellent self-healing property, good cytocompatibility, and antibacterial adhesion was developed. The hydrogel showed a distinct thermal-induced sol-gel transition and could be easily applied to complex wounds. It possessed rapid self-healing ability and low cytotoxicity, and effectively prevented bacterial adhesion, promoting wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Linlin Wang et al.
Summary: Researchers have developed a self-powered patch for treating diabetic wounds that generates reactive oxygen species (ROS) in situ, effectively addressing the limitations of low H2O2 levels. This patch also utilizes an electric field to drive bacteria to adhere to the electrodes, allowing for precise sterilization. In vivo experiments demonstrated its potential in eliminating inflammation and promoting wound healing.
Editorial Material
Dermatology
Chandan K. Sen
Summary: Chronic wounds have a significant impact on the quality of life and healthcare economics in the United States, and the COVID-19 pandemic has disrupted wound care, particularly for patients with chronic wounds. There is a growing interest in understanding how social determinants of health affect wound care patient outcomes, and the pandemic underscores the importance of telemedicine in wound care.
ADVANCES IN WOUND CARE
(2021)
Article
Chemistry, Applied
Miao Zhang et al.
Summary: A novel composite hydrogel was fabricated, promoting cell proliferation and migration for wound healing, while also exhibiting significant antibacterial activity. This study highlights the potential of marine carbohydrate composite hydrogels in wound care management.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Environmental
Peiyuan Wang et al.
Summary: A hydrogel spray containing CuO nanospheres was developed for efficient promotion of diabetic wound healing, with antibacterial and hypoxia alleviation effects. This approach may provide a reliable tool for synergistic reconstruction of chronic non-healing wounds.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Jiahui Zhao et al.
Summary: A simple strategy using ferrous ions and guanosine monophosphate to prepare coordination polymer nanoparticles with excellent peroxidase-like activity and antibacterial effects has been proposed. These nanoparticles have high encapsulation capacity for guest components and show great application potential in the fields of biocatalysis and biomedicine.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Danxia Li et al.
Summary: By designing metal-organic framework-based nanoreactors loaded with glucose oxidase and peroxidase-like bovine hemoglobin, an effective cascaded catalytic antibacterial system has been constructed. This system can both starve and kill multidrug-resistant bacteria, and accelerate diabetic wound healing.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Qianmin Ou et al.
Summary: The hydrogel wound dressings developed by incorporating PUE or FA via PDA nanoparticles show improved enzyme activity, reduced ROS and malondialdehyde levels, promoting wound healing and tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Chemistry, Applied
Urarika Luesakul et al.
CARBOHYDRATE POLYMERS
(2020)
Article
Nanoscience & Nanotechnology
Meng Li et al.
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Engineering, Environmental
Shiyu Chen et al.
CHEMICAL ENGINEERING JOURNAL
(2020)
Review
Multidisciplinary Sciences
Lindsay R. Kalan et al.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2019)
Article
Nanoscience & Nanotechnology
Chengwei Wang et al.
ACS APPLIED MATERIALS & INTERFACES
(2019)
Review
Physiology
Melanie Rodrigues et al.
PHYSIOLOGICAL REVIEWS
(2019)
Article
Nanoscience & Nanotechnology
Jun-Bo Hou et al.
ACS APPLIED MATERIALS & INTERFACES
(2019)
Editorial Material
Biochemistry & Molecular Biology
Idan Yelin et al.
Article
Biochemistry & Molecular Biology
Rashid Ahmed et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Polymer Science
Yingxue Zhou et al.
JOURNAL OF POLYMER RESEARCH
(2014)
