Host-Guest Interaction-Based Supramolecular Self-Assemblies for H2O2 Upregulation Augmented Chemiluminescence Resonance Energy Transfer-Induced Cancer Therapy

Given that light is hard to reach deep tumor tissue, how to enhance photodynamic therapy (PDT) efficacy is a big challenge. Herein, we proposed the supramolecular polymer self-assemblies (HACP) with bis[2,4,5-trichloro-6 (penty-loxycar-bonyl) phenyl] oxalate as the cargos (HACP@CPPO) to realize the chemiluminescence resonance energy transfer (CRET)-induced generation of O-1(2) in situ. HACP was prepared by cinnamaldehyde-modified hyaluronic acid (HA-CA) and beta-cyclodextrin-modified protoporphyrin IX (beta-CD-PPIX) via host-guest interactions. The CA moiety could elevate H2O2 levels for the enhanced production of chemical energy and macrocyclic CD could enhance the stacking distance of PPIX for enhanced O-1(2) yield. Thus, HACP@CPPO exhibited excellent antitumor performance without light irradiation.

Automated summary

As it is difficult for light to reach deep tumor tissue, enhancing the efficacy of photodynamic therapy (PDT) poses a significant challenge. In this study, a supramolecular polymer self-assembly (HACP) with bis[2,4,5-trichloro-6 (penty-loxycar-bonyl) phenyl] oxalate as the cargos (HACP@CPPO) was proposed to achieve chemiluminescence resonance energy transfer (CRET)-induced generation of O-1(2) in situ. HACP was prepared using cinnamaldehyde-modified hyaluronic acid (HA-CA) and beta-cyclodextrin-modified protoporphyrin IX (beta-CD-PPIX) via host-guest interactions. The CA moiety could elevate H2O2 levels for enhanced chemical energy production, while the macrocyclic CD could enhance the stacking distance of PPIX for increased O-1(2) yield. Therefore, HACP@CPPO exhibited excellent antitumor performance without light irradiation.