Water-triggered self-assembly polycondensation for the one-pot synthesis of cyclomatrix polyphosphazene nanoparticles from amino acid ester

Water-triggered self-assembly polycondensation was proposed for preparation of cyclomatrix polyphosphazene nanoparticles from amino acid esters, and a critical solubility parameter was found to determine whether the nanoparticles were formed. Based on this rule, we also investigated the control of the size of its nanoparticles.