期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 24, 页码 5100-5103出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc00085h
关键词
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资金
- Australian Research Council
- JSPS
An enantioselective synthesis of (+)-corynomycolic acid, and its elaboration to esters of trehalose, glucose and glycerol, is described. Trehalose dicorynomycolate and trehalose monocorynomycolate activate human and mouse Mincle as effectively as trehalose dicorynomycolate (cord factor). Glucose monomycolate is revealed to be a potent activator of both mouse and human Mincle. Glycerol monocorynomycolate signals through human Mincle, with the activity predominantly residing in the 2'S-isomer.
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