☆ 3.9 Review

Potential Avenues for Exosomal Isolation and Detection Methods to Enhance Small-Cell Lung Cancer Analysis

ACS MEASUREMENT SCIENCE AU (2023)

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Review Chemistry, Analytical

Recent advances in microfiuidic approaches for the isolation and detection of exosomes

Krishan Kumar et al.

Summary: This paper provides a comprehensive overview of microfluidic devices used to isolate, detect, and analyze exosomes from body fluids, with an emphasis on their designs and working principles from an analytical perspective. Recent progress in the design of microfluidic-based exosome isolation devices is outlined. Challenges and potentials in the clinical translation of these devices are highlighted, and guidelines are offered to engineers and clinicians interested in this field.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2023)

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Review Medicine, Research & Experimental

The role of Exosomal miRNAs in cancer

Chuanyun Li et al.

Summary: Exosomal miRNAs play a critical role in regulating genes and their altered expression is associated with almost all human cancers. They modulate processes that interfere with cancer immunity and microenvironment, and significantly impact tumor growth, invasion, metastasis, angiogenesis, and drug resistance. Understanding the detailed mechanisms of miRNAs in cancer development could contribute to both cancer treatment and prevention of malignant diseases. This review highlights recent advances in cancer-derived exosomal miRNAs, including their sorting and delivery mechanisms, as well as their potential as diagnostic and prognostic markers and in detecting cancer resistance to therapeutic agents.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

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Review Biochemistry & Molecular Biology

Exosomes as a new frontier of cancer liquid biopsy

Dan Yu et al.

Summary: Liquid biopsy, a revolutionary strategy for cancer diagnosis and prognosis prediction, uses minimally invasive detection through biofluids such as blood, saliva, and urine. Exosomes, a subset of extracellular vesicles, play a crucial role in intercellular communication and are considered as potential biomarkers in liquid biopsy. However, the lack of high-quality separation and component analysis methods has limited the further clinical application of exosomes.

MOLECULAR CANCER (2022)

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Review Biotechnology & Applied Microbiology

Review on Strategies and Technologies for Exosome Isolation and Purification

Jiaci Chen et al.

Summary: Exosomes, as nano-sized extracellular vesicles, play an important role in cell-specific material transfer and have potential applications in prognosis, diagnosis, and treatment. Existing exosomal separation techniques have limitations in terms of complexity, time consumption, and low purity, highlighting the need for efficient and simple isolation methods. Microfluidic chips have emerged as a promising technology for exosome isolation. A comprehensive review covering exosomal properties, conventional technologies, emerging isolation strategies, and large-scale production of engineered exosomes is essential.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Biophysics

Exosomal microRNAs array sensor with a bioconjugate composed of p53 protein and hydrazine for the specific lung cancer detection

Rabbee G. Mahmudunnabi et al.

Summary: This study demonstrates a novel strategy for the early diagnosis of lung cancer by detecting microRNAs encapsulated in exosomes using immunomagnetic isolation. The researchers selectively extracted exo-miRNAs from patient serum by capturing miRNA from lysed exosomes with specially designed capture probe modified magnetic beads. The sensor probe formed through T4 DNA polymerase-mediated in situ formation of chimeric 5'-miRNA-DNA-3' (Target) and p53 protein recognition showed excellent analytical performance, with a dynamic range between 100 aM and 10 pM and a detection limit of 92 (+/- 0.1) aM. Furthermore, a multiplexed array sensor was prepared to detect four exo-miRNAs at femtomolar levels in cell culture media and lung cancer patient serum samples.

BIOSENSORS & BIOELECTRONICS (2022)

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Article Oncology

Hypoxic lung cancer cell-derived exosomal miR-21 mediates macrophage M2 polarization and promotes cancer cell proliferation through targeting IRF1

Jianxu Jin et al.

Summary: This study found that tumor cell-derived exosomes in hypoxic environments promote lung cancer progression by targeting IRF1 through miR-21.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2022)

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Article Chemistry, Analytical

Tri-Channel Electrochemical Immunobiosensor for Combined Detections of Multiple Exosome Biomarkers of Lung Cancer

Cui Fan et al.

Summary: Current methods for the early diagnosis of cancer can be invasive and costly. Exosomes have been recognized as potential biomarkers for cancer diagnostics. A tri-channel electrochemical immunobiosensor has been developed for enzyme-free and label-free detection of carcino-embryonic antigen (CEA), neuron-specific enolase (NSE), and cytokeratin 19 fragments (Cyfra21-1) from exosomes for specific early diagnosis of lung cancer. The electrochemical immunobiosensor showed good selectivity and stability, with a detection limit down to 10(-4) ng/mL. Different expression levels of exosomal markers were observed in different types of lung cancer.

BIOSENSORS-BASEL (2022)

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Article Biophysics

Electrochemical nano-sensing interface for exosomes analysis and cancer diagnosis

Shijie Li et al.

Summary: This article presents a review of recent advances in exosome detection based on the electrochemical nano-sensing interface. It discusses the principles of electrochemical analysis, exosome sensing mechanisms, nano-interface construction strategies, and typical diagnostic applications. The integration of nanomaterials and the design of nanostructured electrode arrays enhance the electrochemical performance of the nano-sensing interface for accurate exosome analysis.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Medicine, Research & Experimental

Mechanisms of small cell lung cancer metastasis

Julie Ko et al.

Summary: Metastasis is a major cause of morbidity and mortality in cancer patients, especially with small cell lung cancer (SCLC) known for its remarkable metastatic proclivity. Recent advances in research, such as using circulating tumor cells and genetically engineered mouse models, are helping to overcome limitations in studying SCLC metastasis. New insights into cellular mechanisms associated with increased metastatic ability offer promise for future therapeutic options.

EMBO MOLECULAR MEDICINE (2021)

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Review Oncology

The role of exosomes in liquid biopsy for cancer diagnosis and prognosis prediction

Shiyu Li et al.

Summary: Exosomes, as a new type of liquid biopsy, have the potential to be diagnostic or prognostic biomarkers by delivering cargos including nucleic acids and protein, involving in tumorigenesis, tumor growth, metastasis, and drug resistance.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Nanoscience & Nanotechnology

Platinum Nanoparticles Enhance Exosome Release in Human Lung Epithelial Adenocarcinoma Cancer Cells (A549): Oxidative Stress and the Ceramide Pathway are Key Players

Sangiliyandi Gurunathan et al.

Summary: Several studies have demonstrated the molecular mechanisms involved in the biogenesis and release of exosomes. PtNPs were shown to enhance exosome secretion in A549 cells by inducing oxidative stress and the ceramide pathway. Pre-treatment with NAC could inhibit the PtNPs-induced exosome biogenesis and release.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Biochemical Research Methods

Modern isolation and separation techniques for extracellular vesicles

Thanaporn Liangsupree et al.

Summary: Extracellular vesicles (EVs) are crucial in cellular communication and regulating physiological and pathological processes. Modern isolation techniques are characterized by being time-efficient, easy to operate, and capable of providing EVs with suitable purity and integrity for various applications.

JOURNAL OF CHROMATOGRAPHY A (2021)

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Article Medicine, General & Internal

Small-cell lung cancer

Charles M. Rudin et al.

Summary: Small-cell lung cancer is a type of lung cancer characterized by high proliferative rate, early metastasis, and poor prognosis, strongly associated with tobacco carcinogens. Most patients are diagnosed with metastatic disease, with only a small fraction having potentially curative earlier-stage disease. Genomic profiling reveals extensive chromosomal rearrangements and high mutation burden in SCLC, often involving inactivation of TP53 and RB1 tumor suppressor genes.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Review Chemistry, Physical

Microfluidic-Based Exosome Analysis for Liquid Biopsy

Bingqian Lin et al.

Summary: Liquid biopsy based on exosomes provides valuable information for biomarker analysis, but faces challenges in exosome isolation and molecular detection. The advancement of microfluidics technology has significantly improved the selectivity and sensitivity of exosome capture and molecular detection.

SMALL METHODS (2021)

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Review Oncology

Exosome-based liquid biopsies in cancer: opportunities and challenges

W. Yu et al.

Summary: Liquid biopsy in cancer research has seen significant progress, with efforts focused on utilizing circulating tumor cells, circulating tumor DNA, and extracellular vesicles like exosomes. Exosomes, as part of the intercellular communication system, carry tumor-derived materials and can serve as stable biomarkers for early detection and monitoring of cancer.

ANNALS OF ONCOLOGY (2021)

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Review Medicine, Research & Experimental

Progress of exosomes in the diagnosis and treatment of lung cancer

Kanghong Xu et al.

Summary: Lung cancer has the highest incidence and mortality rates worldwide, lacking early diagnostic biomarkers. Exosomes, as a mode of intercellular communication, play a role in regulating physiological processes in lung cancer by delivering various biomolecules. Studying the role of exosomes in diagnosing and treating lung cancer is crucial for improving treatment outcomes.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Biochemistry & Molecular Biology

Progress on pivotal role and application of exosome in lung cancer carcinogenesis, diagnosis, therapy and prognosis

Ming-Yue Li et al.

Summary: Lung cancer is often diagnosed late with poor prognosis, and conventional treatments are ineffective for metastatic lung cancer. Lung cancer cell-derived exosomes are receiving attention for their potential in carcinogenesis, diagnosis, therapy, and prognosis of lung cancer, with studies looking into their use as drug delivery vehicles and potential clinical applications.

MOLECULAR CANCER (2021)

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Review Oncology

Pathology and Classification of SCLC

Maria Gabriela Raso et al.

Summary: Small cell lung carcinoma (SCLC) is an aggressive, poorly differentiated neuroendocrine carcinoma that accounts for 13% of all lung carcinomas. Pathological and immunohistochemistry markers play a key role in its differential diagnosis, while comprehensive genomic research helps us better understand its molecular characteristics.

CANCERS (2021)

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Anti-Tim4 Grafting Strongly Hydrophilic Metal-Organic Frameworks Immunoaffinity Flake for High-Efficiency Capture and Separation of Exosomes

Lei Zhang et al.

Summary: Exosomes, carrying a large amount of genetic materials, have become the most ideal analysis target for liquid biopsy. A novel Tim4@ILI-01 immunoaffinity material with high capture efficiency and easy release of captured exosomes has been successfully designed and developed, showing great potential for practical clinical applications in cancer diagnosis and prognosis.

ANALYTICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Rolling Circle Amplification-Assisted Flow Cytometry Approach for Simultaneous Profiling of Exosomal Surface Proteins

Xiaoyi Gao et al.

Summary: The study developed a sensitive RCA-assisted FCA method for detecting exosomes and quantifying their surface proteins, showing excellent detection limits. By changing the protein recognition sequence of the DNA primer, variable compositions of four protein markers on exosomes from different cell sources were sensitively detected.

ACS SENSORS (2021)

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Article Oncology

GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer

Hyesun Jeong et al.

Summary: Lung cancer, especially non-small cell lung cancer, is a major cause of cancer-related deaths globally. Early diagnosis is crucial for better prognosis. The proposed biomarker GCC2 shows high specificity and sensitivity in peripheral blood of early lung cancer patients, demonstrating promising potential for improving lung cancer diagnosis.

CANCERS (2021)

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Review Chemistry, Multidisciplinary

Towards microfluidic-based exosome isolation and detection for tumor therapy

Jie Wang et al.

Summary: Exosomes, nano-sized extracellular vesicles secreted by cells, have revolutionized various areas such as liquid biopsies, cancer biology, drug delivery, and immunotherapy. Microfluidic platforms show promise in overcoming the limitations of conventional techniques by offering high precision processing, microscale liquid handling, and integration with various functional units for efficient exosome separation and sensing.

NANO TODAY (2021)

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Review Oncology

Serum Exosomes and Their miRNA Load-A Potential Biomarker of Lung Cancer

Mateusz Smolarz et al.

Summary: Exosomes are emerging as a potential source of cancer biomarkers, particularly through the miRNA content. Despite promising research results, no biomarkers for early cancer detection have been clinically validated yet. This highlights the constant need for new biomarker candidates in the field of lung cancer research.

CANCERS (2021)

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Article Biophysics

Emerging technologies and commercial products in exosome-based cancer diagnosis and prognosis

Mehdi Mohammadi et al.

Summary: This study provides an overview of the role of exosomes in cancer diagnosis and prognosis, investigates emerging exosome technologies, evaluates the advantages and drawbacks of different technologies, and discusses their clinical challenges for cancer diagnosis and prognosis. Commercial platforms for exosomal detection and analysis are introduced, with a focus on their performance and impact on cancer diagnosis and prognosis, as well as the risks associated with the development of next-generation exosome devices.

BIOSENSORS & BIOELECTRONICS (2021)

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Article Chemistry, Multidisciplinary

Characterizing the Heterogeneity of Small Extracellular Vesicle Populations in Multiple Cancer Types via an Ultrasensitive Chip

Jing Wang et al.

Summary: This study introduces a novel platform for characterizing sEV subpopulations, the ESCP, which accurately identifies the phenotypic heterogeneity of sEVs and investigates the role of sEV heterogeneity in cancer progression and metastasis. The ESCP utilizes anti-tetraspanin-functionalized micro-arrays and nanobarcode-based surface-enhanced Raman spectroscopy for multiplexed read-outs, and has been applied to studying sEV phenotypic heterogeneity in cancer cell line models and cancer patient samples.

ACS SENSORS (2021)

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Article Nanoscience & Nanotechnology

Electrochemical micro-aptasensors for exosome detection based on hybridization chain reaction amplification

Wenfen Zhang et al.

Summary: This study presents an electrochemical micro-aptasensor for highly sensitive detection of exosomes, integrating micropatterned electrodes with a hybridization chain reaction (HCR) signal amplification method. The sensor enables specific detection of cancerous exosomes in serum samples with a wide linear detection range and high sensitivity. The method shows great potential for early cancer diagnosis by successfully detecting lung cancer exosomes in both early-stage and late-stage lung cancer patients' serum samples.

MICROSYSTEMS & NANOENGINEERING (2021)

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Article Oncology

Exosomal lncRNA SCIRT/miR-665 Transferring Promotes Lung Cancer Cell Metastasis through the Inhibition of HEYL

Zhengyang Wang et al.

Summary: The study identified that miR-665 and SCIRT are upregulated in lung cancer patients and may promote cancer progression through exosomal transfer. This suggests that these factors play a significant role in cancer and could serve as novel targets for diagnosis and treatment of lung cancer.

JOURNAL OF ONCOLOGY (2021)

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Article Oncology

Exosomal miR-375-3p breaks vascular barrier and promotes small cell lung cancer metastasis by targeting claudin-1

Shuangshuang Mao et al.

Summary: This study identified the crucial role of exosomal miRNA-375-3p in regulating vascular endothelial barrier integrity and SCLC metastasis. miRNA-375-3p has the potential to serve as a novel biomarker for monitoring metastasis and guiding clinical therapeutics in SCLC patients.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

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Review Chemistry, Analytical

Separation of distinct exosome subpopulations: isolation and characterization approaches and their associated challenges

Karishma Singh et al.

Summary: Exosomes are nano-sized extracellular vesicles that serve as a communication system between cells and show promise in various human diseases. Due to their natural heterogeneity, there is a need to separate them into distinct subpopulations for full interrogation of exosome biology before clinical translation. Various technologies and advancements are being explored for better isolation and characterization of exosome subpopulations in clinical practices.

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Shujing Lin et al.

SMALL (2020)

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Recent achievements in exosomal biomarkers detection by nanomaterials-based optical biosensors - A review

Baoyi Shao et al.

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New Approaches to SCLC Therapy: From the Laboratory to the Clinic

John T. Poirier et al.

JOURNAL OF THORACIC ONCOLOGY (2020)

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Role of exosomal microRNAs in lung cancer biology and clinical applications

Chengping Hu et al.

CELL PROLIFERATION (2020)

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Extracellular Vesicles: Current Analytical Techniques for Detection and Quantification

Esther Serrano-Pertierra et al.

BIOMOLECULES (2020)

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Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis

Binglin Yue et al.

CELL PROLIFERATION (2020)

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Exosomal miRNAs as biomarkers for diagnostic and prognosticin lung cancer

Jing Wu et al.

CANCER MEDICINE (2020)

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Genetic Markers in Lung Cancer Diagnosis: A Review

Katarzyna Wadowska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Advances of exosome isolation techniques in lung cancer

Elham O. Mahgoub et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Exosomes as drug delivery systems: A brief overview and progress update

Suyash M. Patil et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Exosomal miR-141 promotes tumor angiogenesis via KLF12 in small cell lung cancer

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Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes

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Aging-US (2020)

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Development of a simple, sensitive and selective colorimetric aptasensor for the detection of cancer-derived exosomes

Lizhou Xu et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Le Zhu et al.

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Jie Dai et al.

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THERANOSTICS (2020)

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Zhi-Hua Xu et al.

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CELLS (2019)

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Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales

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Optimized exosome isolation protocol for cell culture supernatant and human plasma

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Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis

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microRNAs Derived from Circulating Exosomes as Noninvasive Biomarkers for Screening and Diagnosing Lung Cancer

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Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines

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