期刊
BMC GENOMIC DATA
卷 24, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12863-023-01118-5
关键词
Streptococcus pneumoniae; Serotype; Serotype switch; Complete genome; Recombination; Antimicrobial resistance; Tn2010 transposon
This study aimed to obtain and compare the complete genomic sequences of two pneumococcal isolates. Comparative analysis revealed several instances of recombination involving not only pneumococci but also potentially other streptococci as donors.
BackgroundStreptococcus pneumoniae (pneumococcus) represents an important human pathogen, responsible for respiratory and invasive infections in the community. The efficacy of polysaccharide conjugate vaccines formulated against pneumococci is reduced by the phenomenon of serotype replacement in population of this pathogen. The aim of the current study was to obtain and compare complete genomic sequences of two pneumococcal isolates, both belonging to ST320 but differing by the serotype.ResultsHere, we report genomic sequences of two isolates of important human pathogen, S. pneumoniae. Genomic sequencing resulted in complete sequences of chromosomes of both isolates, 2,069,241 bp and 2,103,144 bp in size, and confirmed the presence of cps loci specific for serotypes 19A and 19F. The comparative analysis of these genomes revealed several instances of recombination, which involved not only S. pneumoniae but also presumably other streptococci as donors.ConclusionsWe report the complete genomic sequences of two S. pneumoniae isolates of ST320 and serotypes 19A and 19F. The detailed comparative analysis of these genomes revealed the history of several recombination events, clustered in the region including the cps locus.
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