HOW DO THE GENETIC VARIANTS OF MMP 9 AND TIMP 1 AND VITAMIN D AFFECT CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS?

Objective: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a multifactorial disease in which the sinus and nasal mucosa are affected. We investigated the relationship between the ge-netic polymorphism of MMP9(rs17576) and TIMP1 (rs48498) and serum levels, and we wanted to investigate the effect of MMP9 and TIMP1 genotypes on Vitamin serum levels in CRSwNP with and without Aspirin-Exacerbated Respiratory Disease (AERD). Materials and Methods: This study consisted of 99 patients with CRSwNP with AERD and CRSwNP without AERD. The RT-PCR method and ELISA were used in this study. ELISA was used for MMP9 and TIMP1 serum levels and Vitamin D levels. Results: Serum levels of MMP9 were markedly higher in AG gen-otype than GG genotype in CRSwNP with AERD. Serum levels of MMP9 were statistically higher in carrying of A (+) allele in CRSwNP with AERD than in not carrying of A (+) allele. In ad-dition, serum levels of Vitamin D were discovered significantly lower in TIMP1 CT genotype in comparison to CC and TT geno-types in all of CRSwNP. Conclusion: The rising of MMP9 serum levels may be a marker of chronic inflammation or they may be a significant factor in the

Automated summary

This study investigated the relationship between the genetic polymorphism of MMP9(rs17576) and TIMP1(rs48498) and serum levels, as well as the effect of MMP9 and TIMP1 genotypes on Vitamin D serum levels in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) with and without Aspirin-Exacerbated Respiratory Disease (AERD).