期刊
MATRIX BIOLOGY
卷 55, 期 -, 页码 7-21出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2016.09.009
关键词
Decorin; Proteoglycan; Extracellular matrix; Tumorigenesis; Angiogenesis; Autophagy; Binding-partners
资金
- National Institutes of Health [RO1 CA39481, RO1 CA47282, RO1 CA164462]
- NIH [T32 AA07463]
Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and autophagy. This functional versatility arises from a wide array of decorin/protein interactions also including interactions with its single glycosaminoglycan side chain. The decorin-binding partners encompass numerous categories ranging from extracellular matrix molecules to cell surface receptors to growth factors and enzymes. Despite the diversity of the decorin interacting network, two main roles emerge as prominent themes in decorin function: maintenance of cellular structure and outside-in signaling, culminating in anti-tumorigenic effects. Here we present contemporary knowledge regarding the decorin interacting network and discuss in detail the biological relevance of these pleiotropic interactions, some of which could be targeted by therapeutic interventions. (C) 2016 Published by Elsevier B.V.
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