3.9 Review

Vibration Therapy for Cancer-Related Bone Diseases

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Whole-body vibration training for inpatient children and adolescents receiving chemotherapy for first cancer diagnosis: an exploratory feasibility study

Vanessa Oschwald et al.

Summary: This study investigated the feasibility of whole-body vibration (WBV) training for pediatric cancer patients. The results showed that WBV training is feasible for inpatient pediatric cancer patients with a platelet count of at least 30,000/μL, although the patients' health condition may negatively impact training progression and attendance.

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Reduction of breast cancer extravasation via vibration activated osteocyte regulation

Xin Song et al.

Summary: LMHF vibration can inhibit cancer extravasation in bones by activating osteocytes, suggesting its potential to suppress bone metastasis in breast cancer.

ISCIENCE (2022)

Article Oncology

Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration

Chun-Yu Lin et al.

Summary: The combined treatment of Yoda1 and low-magnitude high-frequency vibration can effectively reduce bone loss caused by bone metastasis, inhibit osteoclast formation, and suppress breast cancer cell migration.

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Doxorubicin Induces Bone Loss by Increasing Autophagy through a Mitochondrial ROS/TRPML1/TFEB Axis in Osteoclasts

Hyun-Jung Park et al.

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Low-Intensity Vibration Protects the Weight-Bearing Skeleton and Suppresses Fracture Incidence in Boys With Duchenne Muscular Dystrophy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Maria Luisa Bianchi et al.

Summary: This study evaluated the effects of low-intensity vibration (LIV) on skeletal decline in individuals with Duchenne Muscular Dystrophy (DMD). The results showed that LIV intervention can help protect the skeleton of DMD children against disease progression and complications associated with chronic steroid use.

JBMR PLUS (2022)

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Microfluidic Co-culture Platforms for Studying Osteocyte Regulation of Other Cell Types under Dynamic Mechanical Stimulation

Chun-Yu Lin et al.

Summary: This review summarizes the recent microfluidic studies on mechanically stimulated osteocytes in regulating other cell types. Microfluidic platforms allow researchers to mimic multicellular environments and study the regulation of osteocytes under mechanical stimulation. These studies contribute to the development of treatment approaches targeting osteocytes under mechanical stimulation.

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Effects of Whole-Body Vibration on Breast Cancer Bone Metastasis and Vascularization in Mice

Takeshi Matsumoto et al.

Summary: This study evaluates whether whole-body vibration can prevent bone loss induced by breast cancer metastasis and investigates the role of bone marrow vasculature. The results show that whole-body vibration can mitigate bone loss in breast cancer bone metastasis and promote bone anabolism. Additionally, alterations in marrow vasculature appear to facilitate the delivery of anti-tumor drugs.

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Estrogen and bones after menopause: a reappraisal of data and future perspectives

Panagiotis Anagnostis et al.

Summary: Menopausal hormone therapy is effective in preventing menopause-related bone loss and decreasing fracture risk, particularly in women with premature ovarian insufficiency or early menopause. However, there are risks such as breast cancer and cardiovascular events that need to be considered, and additional antiosteoporotic therapy may be needed in women at risk of fracture after discontinuing MHT. More research is needed to determine the optimal treatment strategy after discontinuation of MHT.

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Mechanically stimulated osteocytes promote the proliferation and migration of breast cancer cells via a potential CXCL1/2 mechanism

Anushree Dwivedi et al.

Summary: Bone is a common site for breast cancer metastasis, with mechanically stimulated osteocytes releasing factors that enhance cancer cell proliferation and migration. The secretome of mechanically activated osteocytes contains specific cytokines that potentially drive breast cancer metastasis to bone.

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Moderate tibial loading and treadmill running, but not overloading, protect adult murine bone from destruction by metastasized breast cancer

Shubo Wang et al.

Summary: Moderate mechanical loading can suppress tumor-induced bone destruction in breast cancer, but higher magnitude loading can accelerate bone destruction. Different exercise regimens have varying effects on bone cells and bone marrow. Optimization of exercise parameters is needed to harness the skeletal benefits of exercise in metastatic breast cancer.
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Effect of Low-Intensity Vibration on Bone Strength, Microstructure, and Adiposity in Pre-Osteoporotic Postmenopausal Women: A Randomized Placebo-Controlled Trial

Chamith S. Rajapakse et al.

Summary: In this study, vibration therapy was applied to postmenopausal women to examine its effects on bone health. The results showed that vibration therapy could improve bone stiffness, reduce marrow fat fraction, and enhance trabecular bone microstructural parameters. Overall, the intervention with vibration therapy appeared to have protective effects on bone strength and lineage of mesenchymal stem cells.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

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Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesis in vitro

Yuyang Wang et al.

Summary: The study found that radiation-induced premature senescent osteocytes exhibit changes in cell viability, morphology, and protein expression, initiating a senescence-associated secretory phenotype (SASP) that may influence the bone microenvironment, including osteoclastogenesis. This suggests that SASP-targeted interventions could potentially manage radiation-induced bone loss.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis

Raymond K. H. Yip et al.

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Physical Exercise with or without Whole-Body Vibration in Breast Cancer Patients Suffering from Aromatase Inhibitor-Induced Musculoskeletal Symptoms: A Pilot Randomized Clinical Study

Alessandro de Sire et al.

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Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling

Charles A. Schurman et al.

Summary: Skeletal fragility in the elderly is not solely due to bone mass loss, with osteocytes playing a key role in bone aging. The degeneration of the lacunocanalicular network may lead to compromised mechanostimulation of osteocytes, highlighting them as potential targets for age-related therapeutic interventions to improve bone health.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles

Qi Dong et al.

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Emerging Players in Prostate Cancer-Bone Niche Communication

Giulia Furesi et al.

Summary: Patients with advanced prostate cancer often develop skeletal metastases that can lead to fractures, disability, and increased mortality. Interactions between tumor cells and osteoblasts are believed to play a major role in the osteotropism of prostate cancer. Prostate cancer-derived extracellular vesicles (EVs) are emerging as key players in reprogramming osteoblasts and supporting the formation of premetastatic niches, explaining the complexity of prostate cancer osteotropism.

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Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells

Xinxin Yuan et al.

Summary: Exosomes derived from breast cancer cells, particularly SCP28 cells, play a crucial role in promoting osteoclast differentiation and activation, contributing to the accelerated formation of a microenvironment favorable for bone metastasis. Specifically, the exosomal miR-21 from SCP28 cells regulates PDCD4 protein levels to facilitate osteoclastogenesis, indicating its potential as a diagnostic and therapeutic target for breast cancer bone metastasis.

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Micro-vibrations at 30 Hz on bone cells cultivated in vitro produce soluble factors for osteoclast inhibition and osteoblast activity

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Therapy-Induced Senescence Drives Bone Loss

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Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation

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The relationship between whole bone stiffness and strength is age and sex dependent

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The Emerging Role of Osteocytes in Cancer in Bone

Emily G. Atkinson et al.

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Bone metastasis: Interaction between cancer cells and bone microenvironment

Toru Hiraga

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Iliac and mandible osteoblasts exhibit varied responses to LMHF vibration

Anute Pravitharangul et al.

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Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling

Yu-Heng V. Ma et al.

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Effects of low-magnitude high-frequency vibration on osteoblasts are dependent on estrogen receptor alpha signaling and cytoskeletal remodeling

M. Haffner-Luntzer et al.

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Aging, Osteocytes, and Mechanotransduction

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Osteocyte Mechanobiology

Yuhei Uda et al.

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The role of vasculature in bone development, regeneration and proper systemic functioning

Joanna Filipowska et al.

ANGIOGENESIS (2017)

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Bone metastasis risk factors in breast cancer

Catarina Pulido et al.

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Effects of whole body vibration on bone mineral density in postmenopausal women: a systematic review and meta-analysis

L. C. Oliveira et al.

OSTEOPOROSIS INTERNATIONAL (2016)

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Cancer treatment-induced bone loss (CTIBL): Pathogenesis and clinical implications

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Osteocyte specific responses to soluble and mechanical stimuli in a stem cell derived culture model

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Chemotherapy- and Irradiation-Induced Bone Loss in Adults with Solid Tumors

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Physical Activity and Survival among Men Diagnosed with Prostate Cancer

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Low-amplitude high frequency vibration down-regulates myostatin and atrogin-1 expression, two components of the atrophy pathway in muscle cells

Gabriele Ceccarelli et al.

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Irisin in response to acute and chronic whole-body vibration exercise in humans

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In Vivo Tibial Compression Decreases Osteolysis and Tumor Formation in a Human Metastatic Breast Cancer Model

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Effect of 12 Months of Whole-Body Vibration Therapy on Bone Density and Structure in Postmenopausal Women A Randomized Trial

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ANNALS OF INTERNAL MEDICINE (2011)

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The Amazing Osteocyte

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Cancer to bone: a fatal attraction

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Skeletal Effects of Whole-Body Vibration in Adult and Aged Mice

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Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals

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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

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The effect of varying magnitudes of whole-body vibration on several skeletal sites in mice

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Bone loss and the aromatase inhibitors

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Effect of 8-month vertical whole body vibration on bone, muscle performance, and body balance:: A randomized controlled study

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Inhibition of osteopenia by low magnitude, high-frequency mechanical stimuli

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