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In cellulo and in vivo assays for compound testing cruzi

STAR PROTOCOLS (2023)

A bioluminescence reporter mouse strain for in vivo imaging of CD8+ T cell localization and function

Yang Guo et al.

Summary: In this study, a transgenic mouse model was generated via CRISPR-mediated genome editing for non-invasive imaging of CD8(+) T cells, providing a convenient and robust tool for understanding fundamental CD8(+) T cell biology. This novel approach offers the potential for experimental applications and preclinical translational studies.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Cell Biology

Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

Martin Marek et al.

Summary: The zinc-dependent histone deacetylases in the protozoan parasite Trypanosoma cruzi have significantly diverged from their human counterparts, with tcDAC2 displaying essential deacetylase activity and major structural differences. Targeting these atypical HDACs can lead to selective chemical impairment of parasites.

CELL REPORTS (2021)

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Article Parasitology

In vivo imaging of mice infected with bioluminescent Trypanosoma cruzi unveils novel sites of infection

Cristina Henriques et al.

PARASITES & VECTORS (2014)

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Article Multidisciplinary Sciences

Inhibition of Firefly Luciferase by General Anesthetics: Effect on In Vitro and In Vivo Bioluminescence Imaging

Marleen Keyaerts et al.

PLOS ONE (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Temporal Variations of Skin Pigmentation in C57Bl/6 Mice Affect Optical Bioluminescence Quantitation

Allison Curtis et al.

MOLECULAR IMAGING AND BIOLOGY (2011)

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In cellulo and in vivo assays for compound testing cruzi

相关参考文献

A bioluminescence reporter mouse strain for in vivo imaging of CD8+ T cell localization and function

Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

In vivo imaging of mice infected with bioluminescent Trypanosoma cruzi unveils novel sites of infection

Inhibition of Firefly Luciferase by General Anesthetics: Effect on In Vitro and In Vivo Bioluminescence Imaging

Temporal Variations of Skin Pigmentation in C57Bl/6 Mice Affect Optical Bioluminescence Quantitation

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