The embryo mosaicism profile of next-generation sequencing PGT-A in different clinical conditions and their associations

Article Multidisciplinary Sciences

The first mitotic division of human embryos is highly error prone

Cerys E. Currie et al.

Summary: This study reveals that errors in chromosome segregation during the first mitotic division of human embryos can be tolerated and uncovers the cell biological events that contribute to preimplantation mosaicism.

NATURE COMMUNICATIONS (2022)

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Article Obstetrics & Gynecology

P-556 Younger maternal age as a factor associated with embryonic mosaicism. Analysis of 3222 blastocyst by Next Generation Sequencing

P.E Villanueva Zúñiga et al.

HUMAN REPRODUCTION (2022)

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Article Obstetrics & Gynecology

ESHRE survey results and good practice recommendations on managing chromosomal mosaicism

Martine De Rycke et al.

Summary: This study provides 30 good practice recommendations for ART/PGT centres to manage the detection of chromosomal mosaicism in 'mosaic' embryos. Data shows varying criteria for designating mosaicism, reporting and transfer policies across centres, emphasizing the need for standardized practices.

HUMAN REPRODUCTION OPEN (2022)

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Article Genetics & Heredity

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial

Antonio Capalbo et al.

Summary: Research has shown that low-medium mosaicism in the trophectoderm mostly arises after TE and ICM differentiation, and such embryos have equivalent developmental potential as fully euploid ones.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

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Article Genetics & Heredity

The Incidence of Mosaicism for Individual Chromosome in Human Blastocysts Is Correlated With Chromosome Length

Tzu-Hsuan Chuang et al.

Summary: Mosaicism, originating from mitotic errors, consists of different cell lineages within an embryo; its frequency does not correlate with maternal age and its association with individual chromosome characteristics is not well understood. A study found that aneuploidy is more common on shorter chromosomes, while mosaicism is more frequent on longer chromosomes, and this association is not affected by advanced maternal age.

FRONTIERS IN GENETICS (2021)

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Article Obstetrics & Gynecology

Using outcome data from one thousand mosaic embryo transfers to formulate an embryo ranking system for clinical use

Manuel Viotti et al.

Summary: This study investigated how the attributes of mosaicism identified during preimplantation genetic testing for aneuploidy are related to clinical outcomes, and formulated a ranking system for mosaic embryos. The results showed that euploid embryos had significantly better outcomes compared to mosaic embryos, with outcomes influenced by the level and type of mosaicism. Combining mosaic level, type, and embryo morphology revealed a ranking of subcategories regarding the likelihood of positive outcome.

FERTILITY AND STERILITY (2021)

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Article Genetics & Heredity

Blastocyst Morphology Based on Uniform Time-Point Assessments is Correlated With Mosaic Levels in Embryos

Chien-Hong Chen et al.

Summary: Avoiding aneuploid embryo transfers can improve pregnancy outcomes in patients with implantation failure and pregnancy loss. Time-lapse-based variables and numeric blastocyst morphological scores are significantly correlated with different mosaic levels, indicating their potential predictive value for identifying abnormal ploidy risk in blastocysts.

FRONTIERS IN GENETICS (2021)

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Article Genetics & Heredity