4.7 Article

N-Heterocyclic carbene-catalyzed [2+3] cyclocondensation of α-chloroaldehydes with azomethine imines

期刊

CHEMICAL COMMUNICATIONS
卷 51, 期 45, 页码 9328-9331

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01238d

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资金

  1. National Science Foundation of China [21425207, 21272237]
  2. Open Project Program of National Engineering Research Center for Carbohydrate Synthesis of Jiangxi Normal University
  3. Chinese Academy of Sciences

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An N-heterocyclic carbene-catalyzed enantioselective [2+3] cyclocondensation of alpha-chloroaldehydes with azomethine imines was developed. The corresponding pyrazolidinones were obtained in good yields with moderate to good diastereoselectivities and excellent enantioselectivities.

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