Thyroid [123I]MIBG uptake in Parkinson?s disease and diabetes mellitus

Thyroid [123I]MIBG uptake is proposed as a tool for differentiating between Parkinson's disease (PD) and dia-betes mellitus (DM) on [123I]MIBG scintigraphies since both patient groups show decreased cardiac uptake. One study compared thyroid [123I]MIBG uptake in DM and PD patients and reported reduced [123I]MIBG uptake only in the PD group. Here, we investigated thyroid [123I]MIBG uptake in patients with PD and DM and found severely reduced thyroid [123I]MIBG uptake in DM. Larger studies are needed to substantiate whether DM patients are more or less likely to exhibit decreased thyroid MIBG uptake compared to controls and PD patients.

Automated summary

Thyroid [123I]MIBG uptake is proposed as a tool to differentiate between Parkinson's disease (PD) and diabetes mellitus (DM). A study found reduced [123I]MIBG uptake only in the PD group. However, our investigation showed severely reduced [123I]MIBG uptake in DM patients. Further studies are needed to determine the likelihood of decreased thyroid MIBG uptake in DM patients compared to controls and PD patients.