A microneedle-based delivery system for broad-protection seasonal influenza A DNA nanovaccines

Article Pharmacology & Pharmacy

Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency

Li Yang et al.

Summary: A micro-needle patch based on silk protein has been developed for sustained release of recombinant human growth hormone, providing a new treatment method for growth hormone deficiency.

ACTA PHARMACEUTICA SINICA B (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Core-Shell Structured Chitosan-Polyethylenimine Nanoparticles for Gene Delivery: Improved Stability, Cellular Uptake, and Transfection Efficiency

Jens Casper et al.

Summary: The study investigates the improvement of nucleic acid delivery by using depolymerized chitosan-polyethylenimine DNA complexes. This modular approach combines core-dCS-linear PEI/DNA complexes with a shell consisting of dCS-PEG-COOH, resulting in improved nucleic acid encapsulation, cellular uptake, and transfection potency. The optimized ternary complex shows high reporter gene signal for three days after administration, indicating its potential for in vitro and in vivo gene delivery.

MACROMOLECULAR BIOSCIENCE (2023)

添加到收藏夹

Article Biophysics

New insights on the mechanism of polyethylenimine transfection and their implications on gene therapy and DNA vaccines

Juan Sabin et al.

Summary: Polyethylenimine (PEI) has a strong affinity with cell membranes, which sheds light on its mechanism of DNA release. PEI alone cannot enter the cell nucleus but forms a peripheral aureole. The hydrophobic and electrostatic interactions between PEI and lipidic layers allow it to intercalate through the model membranes. This understanding can contribute to the development of better gene therapy and DNA vaccines.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Polymeric microneedle-mediated sustained release systems: Design strategies and promising applications for drug delivery

Li Yang et al.

Summary: Parenteral sustained release drug formulations have been widely used in clinical practice as preferable platforms for long-term exposure therapy. However, the requirement for hypodermic injection hinders their further applications due to issues such as needle-phobia, needle-stick injuries, and inappropriate needle reuse. Microneedles offer an alternative system that is minimally invasive and allows for self-administration.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2022)

添加到收藏夹

Article Immunology

Microneedle patch as a new platform to effectively deliver inactivated polio vaccine and inactivated rotavirus vaccine

Sung-Sil Moon et al.

Summary: In this study, we optimized the formulations of inactivated rotavirus vaccine (IRV) and inactivated poliovirus vaccine (IPV) and successfully manufactured a combined dissolving microneedle patch (dMNP). The dMNP showed good compatibility and immunogenicity in rats. The findings support further development of this innovative approach to deliver a novel combination vaccine against rotavirus and poliovirus.

NPJ VACCINES (2022)

添加到收藏夹

Article Engineering, Biomedical

Intradermal delivery of mRNA using cryomicroneedles

Jinming Yu et al.

Summary: This study explores the usage of cryomicroneedles for the intradermal delivery of mRNA molecules. CryoMNs successfully induce specific immune responses in the mouse model. This work is expected to provide a new delivery strategy for emerging mRNA therapeutics.

ACTA BIOMATERIALIA (2022)

添加到收藏夹

Review Virology

Progress towards the Development of a Universal Influenza Vaccine

Wen-Chien Wang et al.

Summary: Influenza viruses are a major cause of millions of cases globally and pose a significant threat to public health. Current seasonal influenza vaccines provide limited protection and are less effective against mismatched strains. The development of a universal influenza vaccine targeting conserved antigen domains is underway to provide broader protection.

VIRUSES-BASEL (2022)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Evaluation of a Novel DNA Vaccine Double Encoding Somatostatin and Cortistatin for Promoting the Growth of Mice

Xuan Luo et al.

Summary: Growth trait is crucial for livestock species’ economics. Although somatostatin DNA vaccine for enhanced growth has been developed, the effect remains unsatisfying. This study evaluated a novel eukaryotic dual expression vaccine, pIRES-S/CST14-S/2SS, in mice. The results showed that pIRES-S/CST14-S/2SS could effectively express CST and SS in GH3 cells, leading to lower GH and PRL levels. Mice immunized with pIRES-S/CST14-S/2SS vaccine exhibited higher levels of anti-SS antibodies and GH secretion, resulting in greater body weight gain. This study enhances our understanding of the relationship between somatostatin and cortistatin and may contribute to the development of effective growth-promoting DNA vaccines in animals.

ANIMALS (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Quaternized chitosan-coated liposomes enhance immune responses by co-delivery of antigens and resveratrol

Rui Xing et al.

Summary: This study developed a nanoparticle delivery system by encapsulating the immunomodulator resveratrol in quaternized chitosan-coated liposomes. These liposomes successfully co-localized antigens and immunomodulators in antigen-presenting cells, resulting in enhanced immune responses. The system effectively promoted the co-uptake of antigen and resveratrol by dendritic cells and induced a mixed Th1/Th2 immune response.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Glycosylation of OVA antigen-loaded PLGA nanoparticles enhances DC-targeting for cancer vaccination

Po-Yu Chou et al.

Summary: In this study, glycosylated poly(lactic-co-glycolic acid) nanoparticles (NPs) loaded with tumor-specific antigens and adjuvants were developed for targeted delivery to dendritic cells (DCs). The results showed that the glycosylated NPs effectively enhanced antigen uptake and DC maturation, and promoted cellular immunity and T-cell recruitment into tumor sites in vivo.

JOURNAL OF CONTROLLED RELEASE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Plasmid-DNA Delivery by Covalently Functionalized PEI-SPIONs as a Potential 'Magnetofection' Agent

Rene Stein et al.

Summary: Nanoformulations for delivering nucleotides into cells have gained attention for vaccinations and treatment. This study focuses on synthesizing superparamagnetic iron oxide nanoparticles for potential magnetofection applications. The functionalized nanoparticles showed improved transfection efficiency and stability, making them a promising candidate for magnetofection agents.

MOLECULES (2022)

添加到收藏夹

Article Immunology

Transcutaneous immunization via dissolving microneedles protects mice from lethal influenza H7N9 virus challenge

Siqi Liu et al.

VACCINE (2022)

添加到收藏夹

Review Nanoscience & Nanotechnology

Microneedle-based ocular drug delivery systems-recent advances and challenges

Piotr Gadzinski et al.

Summary: Eye diseases and injuries are a significant clinical problem worldwide. Traditional eye drops, gels, and ointments are often not well tolerated by patients. However, microneedle-based systems have made remarkable advances in recent years as an alternative, non-invasive form of drug administration.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2022)

添加到收藏夹

Article Biology

A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

Jing Zhang et al.

Summary: This study presents a broad-spectrum vaccine candidate, mos-tri-RBD, which carries key mutations from Omicron and other variants, and is capable of eliciting potent cross-neutralizing antibodies against not only Omicron but also other immune-evasive variants.

ELIFE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Christmas Tree-Shaped Microneedles as FOLFIRINOX Spatiotemporal Delivery System for Pancreatic Cancer Treatment

Danqing Huang et al.

Summary: The study introduces a novel Christmas tree-shaped adhesive microneedle patch capable of spatiotemporal multiple-drug delivery, effectively treating pancreatic cancer.

RESEARCH (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Fei Qu et al.

Summary: Skin diseases have a significant impact on patients' quality of life and the global economy. Advanced transdermal drug delivery strategies, such as nanocarrier and microneedle-based systems, offer efficient and targeted drug delivery with reduced side effects and improved functions.

THERANOSTICS (2022)

添加到收藏夹

Article Biotechnology & Applied Microbiology

A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells

Giang N. Nguyen et al.

Summary: Nine dogs with hemophilia A were treated with AAV gene therapy expressing canine factor VIII and followed for up to 10 years. The therapy corrected the FVIII deficiency in most dogs, with some showing gradual increase in FVIII activity possibly due to clonal expansion of cells. Long-term monitoring for potential genotoxicity is essential for the clinical development of liver-directed AAV gene therapy for hemophilia A.

NATURE BIOTECHNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination

Dengning Xia et al.

Summary: The novel ePatch system enables low-cost, handheld DNA vaccination against SARS-CoV-2, inducing strong antibody responses with at least 10-fold dose sparing compared to conventional injection methods. The vaccination process is well tolerated with mild, transient effects on the skin, offering a portable and accessible approach for combating COVID-19 and other epidemics.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting

Yanmei He et al.

Summary: By developing cascade-targeting, dual drug-loaded core-shell nanoparticles, precise drug delivery to tumors and overcoming biological barriers were achieved; the degradation of hyaluronic acid shell facilitated drug release and cellular uptake, while the exposure of triphenylphosphonium derivative core allowed for mitochondria-targeted delivery, ultimately inhibiting tumor growth.

SCIENCE ADVANCES (2021)

添加到收藏夹

Article Medicine, General & Internal

Vaccine Efficacy of ALVAC-HIV and Bivalent Subtype C gp120-MF59 in Adults

Glenda E. Gray et al.

Summary: The ALVAC-gp120 vaccine regimen did not prevent HIV-1 infection among participants in South Africa, despite previous evidence of immunogenicity. This phase 2b-3 trial showed that further vaccinations were halted due to lack of efficacy in preventing HIV-1 infection.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Separable Microneedle Patch to Protect and Deliver DNA Nanovaccines Against COVID-19

Yue Yin et al.

Summary: The successful control of the COVID-19 pandemic relies not only on vaccine development, but also on efficient storage, transportation, and administration. Current nucleic acid vaccines stored frozen may face limitations in developing countries due to storage requirements. A separable microneedle patch has been developed to deliver vaccines intradermally, showing promising results in inducing strong and lasting immune responses compared to intramuscular injection.

ACS NANO (2021)

添加到收藏夹

News Item Multidisciplinary Sciences

INDIA'S DNA COVID VACCINE IS A WORLD FIRST - MORE ARE COMING

Smriti Mallapaty

NATURE (2021)

添加到收藏夹

Article Medicine, General & Internal

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial

Pablo Tebas et al.

Summary: The study found that the INO-4800 vaccine performed well in inducing immune responses and had good safety, with no serious adverse events reported. Participants exhibited both cellular and humoral immune responses to the vaccine, indicating its effectiveness in eliciting immunity.

ECLINICALMEDICINE (2021)

添加到收藏夹

Article Pediatrics

Subacute Liver Failure Following Gene Replacement Therapy for Spinal Muscular Atrophy Type 1

Amy G. Feldman et al.

JOURNAL OF PEDIATRICS (2020)

添加到收藏夹

Review Immunology

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors

Giuseppe Ronzitti et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection

Honglei Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Review Multidisciplinary Sciences

Smart Microneedles for Therapy and Diagnosis

Xiaoxuan Zhang et al.

RESEARCH (2020)

添加到收藏夹

Article Immunology

Intradermal SynCon® Ebola GP DNA Vaccine Is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers

Pablo Tebas et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

添加到收藏夹

Article Engineering, Biomedical

DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen

Grace Cole et al.

ACTA BIOMATERIALIA (2019)

添加到收藏夹

Article Infectious Diseases

Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial

Kayvon Modjarrad et al.

LANCET INFECTIOUS DISEASES (2019)

添加到收藏夹

Article Immunology

Dengue Mosaic Vaccines Enhance Cellular Immunity and Expand the Breadth of Neutralizing Antibody Against All Four Serotypes of Dengue Viruses in Mice

Jue Hou et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

A mosaic hemagglutinin-based influenza virus vaccine candidate protects mice from challenge with divergent H3N2 strains

Felix Broecker et al.

NPJ VACCINES (2019)

添加到收藏夹

Article Infectious Diseases

Early season co-circulation of influenza A(H3N2) and B(Yamagata): interim estimates of 2017/18 vaccine effectiveness, Canada, January 2018

Danuta M. Skowronski et al.

EUROSURVEILLANCE (2018)

添加到收藏夹

Article Medicine, General & Internal

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

A. Danielle Iuliano et al.

LANCET (2018)

添加到收藏夹

Article Public, Environmental & Occupational Health

Interim Estimates of 2017–18 Seasonal Influenza Vaccine Effectiveness — United States, February 2018

Brendan Flannery et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2018)

添加到收藏夹

Correction Biochemistry & Molecular Biology

Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling (vol 17, 107, 2018)

Fuqing Hu et al.

MOLECULAR CANCER (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Effective humoral immune response from a H1N1 DNA vaccine delivered to the skin by microneedles coated with PLGA-based cationic nanoparticles

HaeYong Seok et al.

JOURNAL OF CONTROLLED RELEASE (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

DNA Vaccine Delivery and Improved Immunogenicity

Kevin R. Porter et al.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2017)

添加到收藏夹

Review Immunology

T follicular regulatory cells

Peter T. Sage et al.

IMMUNOLOGICAL REVIEWS (2016)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Applications of nanoparticle systems in gene delivery and gene therapy

Taiebeh Kafshdooz et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pumilio1 Haploinsufficiency Leads to SCA1-like Neurodegeneration by Increasing Wild-Type Ataxin1 Levels

Vincenzo A. Gennarino et al.

CELL (2015)

添加到收藏夹

Review Veterinary Sciences

Large Animal Models for Vaccine Development and Testing

Volker Gerdts et al.

ILAR JOURNAL (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Streptococcus mutans irvA Gene Encodes a trans-Acting Riboregulatory mRNA

Nan Liu et al.

MOLECULAR CELL (2015)

添加到收藏夹

Article Engineering, Biomedical

MSC-based VEGF gene therapy in rat myocardial infarction model using facial amphipathic bile acid-conjugated polyethyleneimine

Hyung-Ho Moon et al.

BIOMATERIALS (2014)

添加到收藏夹

Review Immunology

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

Shane Crotty

IMMUNITY (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Polyplex-releasing microneedles for enhanced cutaneous delivery of DNA vaccine

Nak Won Kim et al.

JOURNAL OF CONTROLLED RELEASE (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment

Zhou J. Deng et al.

ACS NANO (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Anti-apoptotic cardioprotective effects of SHP-1 gene silencing against ischemia-reperfusion injury: Use of deoxycholic acid-modified low molecular weight polyethyleneimine as a cardiac siRNA-carrier

Dongkyu Kim et al.

JOURNAL OF CONTROLLED RELEASE (2013)

添加到收藏夹

Article Microbiology

New World Bats Harbor Diverse Influenza A Viruses

Suxiang Tong et al.

PLOS PATHOGENS (2013)

添加到收藏夹

Review Immunology

Vector Design for Improved DNA Vaccine Efficacy, Safety and Production

James A. Williams

VACCINES (2013)

添加到收藏夹

Article Chemistry, Multidisciplinary

Bioreducible Crosslinked Polyelectrolyte Complexes for MMP-2 siRNA Delivery into Human Vascular Smooth Muscle Cells

Dokyoung Lee et al.

PHARMACEUTICAL RESEARCH (2012)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cell-penetrating peptides: breaking through to the other side

Erez Koren et al.

TRENDS IN MOLECULAR MEDICINE (2012)

添加到收藏夹

Article Biochemical Research Methods

Construction of a bicistronic vector for the co-expression of two genes in Caenorhabditis elegans using a newly identified IRES

Dirui Li et al.

BIOTECHNIQUES (2012)

添加到收藏夹

Article Instruments & Instrumentation

Enabling skin vaccination using new delivery technologies

Yeu-Chun Kim et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2011)

添加到收藏夹

Review Chemistry, Applied

Transcutaneous Immunization: An Overview of Advantages, Disease Targets, Vaccines, and Delivery Technologies

Pankaj Karande et al.

ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 1 (2010)

添加到收藏夹

Article Virology

Kinetics of Immune Responses to Influenza Virus-Like Particles and Dose-Dependence of Protection with a Single Vaccination

Fu Shi Quan et al.

JOURNAL OF VIROLOGY (2009)

添加到收藏夹

Editorial Material Immunology

Genetic background and the dilemma of translating mouse studies to humans

Juan Rivera et al.

IMMUNITY (2008)

添加到收藏夹

Article Immunology

Immune-cell lineage commitment: Translation from mice to humans

Kimberly J. Payne et al.

IMMUNITY (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants

Will Fischer et al.

NATURE MEDICINE (2007)

添加到收藏夹

Article Health Care Sciences & Services

Updating the accounts: global mortality of the 1918-1920 Spanish influenza pandemic

NPAS Johnson et al.

BULLETIN OF THE HISTORY OF MEDICINE (2002)

添加到收藏夹

Article Virology

An antibody that prevents the hemagglutinin low pH fusogenic transition

C Barbey-Martin et al.

VIROLOGY (2002)

添加到收藏夹

A microneedle-based delivery system for broad-protection seasonal influenza A DNA nanovaccines

相关参考文献

导出引文

分享论文