A comparison of postpartum opioid consumption and opioid discharge prescriptions among opioid-naive patients and those with opioid use disorder

BACKGROUND: Management of patients with opioid use disorder during the acute postpartum period remains clinically challenging as obstetricians aim to mitigate postdelivery pain while optimizing recovery support. OBJECTIVE: This study aimed to evaluate postpartum opioid consump-tion and opioids prescribed at discharge among patients with opioid use disorder treated with methadone, buprenorphine, and no medication for opioid use disorder, as compared with opioid-naive counterparts. STUDY DESIGN: We conducted a retrospective cohort study of preg-nant patients who underwent delivery at >20 weeks' gestation at a tertiary academic hospital between May 2014 and April 2020. The primary outcome of this analysis was the mean daily quantity of oral opioids con-sumed after delivery while inpatient, in milligrams of morphine equivalents. Secondary outcomes included the following: (1) quantity of oral opioids prescribed at discharge, and (2) prescription for oral opioids in the 6 weeks after hospital discharge. Multiple linear regression was used to compare differences in the primary outcome. RESULTS: A total of 16,140 pregnancies were included. Patients with opioid use disorder (n=553) consumed 14 milligrams of morphine equiva-lents per day greater quantities of opioids postpartum than opioid-naive women (n=15,587), (95% confidence interval, 11-17). Patients with opi-oid use disorder undergoing cesarean delivery consumed 30 milligrams of morphine equivalents per day greater quantities of opioids than opioid-naive counterparts (95% confidence interval, 26-35). Among patients who underwent vaginal delivery, there was no difference in opioid con-sumption among patients with and without opioid use disorder. Compared with patients prescribed methadone, patients prescribed buprenorphine, and those prescribed no medication for opioid use disorder consumed similar opioid quantities postpartum following both vaginal and cesarean delivery. Among patients undergoing cesarean delivery, opioid-naive patients were more likely to receive a discharge prescription for opioids than patients with opioid use disorder (77% vs 68%; P=.002), despite lower pain scores and less inhospital opioid consumption. CONCLUSION: Patients with opioid use disorder, regardless of treat-ment with methadone, buprenorphine, or no medication for opioid use dis-order consumed significantly greater quantities of opioids after cesarean delivery but received fewer opioid prescriptions at discharge.

Automated summary

This study aimed to compare postpartum opioid consumption and prescriptions among patients with opioid use disorder and opioid-naive counterparts. The results showed that patients with opioid use disorder consumed significantly greater quantities of opioids after cesarean delivery, regardless of treatment with methadone, buprenorphine, or no medication.