LINKing signaling domains to enhance CAR T cells

The lack of tumor-specific surface antigens has limited the application of CAR T cells in solid tumors. A new AND-gated CAR T cell system repurposes proximal T cell signaling proteins to restrict activation to dual antigen encounter, mitigating on-target, off-tumor toxicity while preserving antitumor efficacy in preclinical models.

Automated summary

The lack of tumor-specific surface antigens hampers the use of CAR T cells in solid tumors. A new AND-gated CAR T cell system utilizes proximal T cell signaling proteins to restrict activation only when encountering dual antigens, reducing on-target, off-tumor toxicity and maintaining antitumor efficacy in preclinical models.